|Official Full Name||coagulation factor II (thrombin)|
|Background||Thrombin (activated Factor II [IIa]) is a coagulation protein that has many effects in the coagulation cascade. Thrombin is a serine protease (EC 220.127.116.11) that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. Thrombin is in the form of alpha-thrombin tat is the immediate end product of prothrombin activation, two further thrombin products can be identified, beta- and gamma-thrombin. These are degraded form that may arise from autodigestion of a thrombin preparation.|
|Synonyms||F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
f2 involved in several pathways and played different roles in them. We selected most pathways f2 participated on our site, such as Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with f2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Neuroactive ligand-receptor interaction||TAAR14H; GABRR3; PTGER3; F2; PTGER1C; HTR2C; GRIN2A; TAAR10; GNRHR1; AVPR1A|
|Complement and coagulation cascades||C8G; THBD; C7; C4BPA; TFPI; SERPINA1A; CR1; MBL1; PROS1; F3|
|Regulation of actin cytoskeleton||MSNB; GIT1; FGF8; MYL1; EGFRA; SSH2; CHRM5A; MYLK3; FN1; PAK2A|
f2 has several biochemical functions, for example, calcium ion binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by f2 itself. We selected most functions f2 had, and list some proteins which have the same functions with f2. You can find most of the proteins on our site.
|calcium ion binding||PLS3; CALB1; FKBP7; CANT1A; FBLN7; S100A10A; KCNIP1; PVALB2; NCS1A; PCDH18|
|growth factor activity||PDGFAB; OGN; CECR1; FGF12; TGFB2; VEGFB; TDGF1; LEFTY2; BDNF; DKK1|
|protein binding||KLF13; HILPDA; SPATA13; NAT9; TPCN2; PIFO; DHRS2; INPP5K; KDM4A; SEMA4D|
|receptor binding||FGF1B; FYNB; PTK2AB; TNFSF18; GSDMA2; CD160; PICK1; INSL3; UTS2; Ar|
|serine-type endopeptidase activity||HTRA4; CFD; KLK1B3; GZMF; HTRA1B; MMP2; CELA3B; ELANE; PRSS30; KLK1B4|
|thrombospondin receptor activity||CD47; SDC4; F2|
f2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f2 here. Most of them are supplied by our site. Hope this information will be useful for your research of f2.
q846v4_staau; anti-thrombin_mus_pe; C1QBP; THBD