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Official Full Name coagulation factor II (thrombin)
Background Thrombin (activated Factor II [IIa]) is a coagulation protein that has many effects in the coagulation cascade. Thrombin is a serine protease (EC that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. Thrombin is in the form of alpha-thrombin tat is the immediate end product of prothrombin activation, two further thrombin products can be identified, beta- and gamma-thrombin. These are degraded form that may arise from autodigestion of a thrombin preparation.
Synonyms F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Bovine Plasma
    • Cattle Blood
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human plasma
    • Mammalian Cell
    • Mouse Plasma
    • NS0
    • Pig Blood
    • Plasma
    • Porcine
    • Porcine Blood
    • Procine Blood
    • Rat plasma
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human F2-069H Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human F2-1103H Recombinant Human F2 Protein, His-tagged NS0 His
    Human F2-12619H Recombinant Human F2 Protein, His-tagged E.coli His
    Human F2-170H Recombinant Human F2 E.coli N/A
    Human F2-180H Antithrombin Reference standard N/A
    Human F2-1882H Native Human Coagulation Factor II Human Plasma N/A
    Human F2-22H Human FEIBA Reference Standard(plasma derived) Reference standard N/A
    Human F2-305H Recombinant Human Coagulation Factor II (F2) protein, His-tagged HEK293 His
    Human F2-3610H Recombinant Human F2 Protein, GST-tagged Wheat Germ GST
    Human F2-5285H Native Human Coagulation Factor II (thrombin) Human plasma N/A
    Human F2-698H Recombinant Human F2 protein, His & GST-tagged E.coli His/GST
    Human F2-955H Recombinant Human F2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human Prothrombin-59H Native Human Prothrombin Frag 1 N/A
    Human Prothrombin-60H Native Human Prothrombin Frag 2 N/A
    Human Thrombin-8H Human Thrombin Reference standard N/A
    Mouse F2-1186M Recombinant Mouse F2, His tagged Human Cell His
    Mouse F2-2124MCL Recombinant Mouse F2 cell lysate Human Cell N/A
    Mouse F2-5287M Native Mouse Coagulation Factor II Mouse Plasma N/A
    Mouse F2-699M Recombinant Mouse F2 protein, His & T7-tagged E.coli His/T7
    Mouse F2-7769M Recombinant Mouse F2 protein, His-tagged E.coli His
    Mouse F2-995M Recombinant Mouse F2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Thrombin-31M Native Mouse Thrombin Plasma N/A
    Mouse Thrombin-61M Native Mouse Thrombin N/A
    Rat F2-303R Native Rat Thrombin N/A
    Rat F2-366R Recombinant Rat F2 Protein, His-tagged HEK293 His
    Rat F2-5286R Native Rat Coagulation Factor II Rat plasma N/A
    Rat F2-700R Recombinant Rat F2 protein, His-tagged E.coli His
    Rat F2-73R Native Rat Prothrombin rat plasma N/A
    Rat F2-7770R Recombinant Rat F2 protein, His-tagged E.coli His
    Rhesus Macaque F2-1531R Recombinant Rhesus monkey F2 Protein, His-tagged Mammalian Cell His
    Bovine F2-274B Native Bovine α-Thrombin Plasma N/A
    Bovine F2-275B Native Bovine α-Thrombin-DFP Plasma N/A
    Bovine F2-276B Native Bovine α-Thrombin-FPRck (FPR-CMK*) Plasma N/A
    Bovine F2-277B Native Bovine α-Thrombin-BFPRck (Biotin) Plasma N/A
    Bovine F2-5401B Native Bovine Coagulation Factor II (thrombin) Bovine Plasma N/A
    Bovine F2-90B Native Bovine Thrombin Bovine Plasma N/A
    Bovine Prothrombin-270B Native Bovine Prothrombin Plasma N/A
    Bovine Prothrombin-271B Native Bovine Prothrombin Frag 1 Plasma N/A
    Chicken F2-6173C Recombinant Chicken F2 Mammalian Cell His
    Zebrafish F2-12566Z Recombinant Zebrafish F2 Mammalian Cell His
    Pig F2-5402P Native Porcine Coagulation Factor II (thrombin) Porcine N/A
    Pig F2-647P Native Pig F2 Procine Blood N/A
    Pig Thrombin-20H Native Pig Thrombin Pig Blood N/A
    Cattle Thrombin-21H Native Cattle Thrombin Cattle Blood N/A
    Pig Thrombin-24P Recombinant Porcine Thrombin Porcine Blood N/A

    f2 involved in several pathways and played different roles in them. We selected most pathways f2 participated on our site, such as Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with f2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction TAAR14H; GABRR3; PTGER3; F2; PTGER1C; HTR2C; GRIN2A; TAAR10; GNRHR1; AVPR1A
    Complement and coagulation cascades C8G; THBD; C7; C4BPA; TFPI; SERPINA1A; CR1; MBL1; PROS1; F3
    Regulation of actin cytoskeleton MSNB; GIT1; FGF8; MYL1; EGFRA; SSH2; CHRM5A; MYLK3; FN1; PAK2A

    f2 has several biochemical functions, for example, calcium ion binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by f2 itself. We selected most functions f2 had, and list some proteins which have the same functions with f2. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PLS3; CALB1; FKBP7; CANT1A; FBLN7; S100A10A; KCNIP1; PVALB2; NCS1A; PCDH18
    growth factor activity PDGFAB; OGN; CECR1; FGF12; TGFB2; VEGFB; TDGF1; LEFTY2; BDNF; DKK1
    protein binding KLF13; HILPDA; SPATA13; NAT9; TPCN2; PIFO; DHRS2; INPP5K; KDM4A; SEMA4D
    receptor binding FGF1B; FYNB; PTK2AB; TNFSF18; GSDMA2; CD160; PICK1; INSL3; UTS2; Ar
    serine-type endopeptidase activity HTRA4; CFD; KLK1B3; GZMF; HTRA1B; MMP2; CELA3B; ELANE; PRSS30; KLK1B4
    thrombospondin receptor activity CD47; SDC4; F2

    f2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f2 here. Most of them are supplied by our site. Hope this information will be useful for your research of f2.

    q846v4_staau; anti-thrombin_mus_pe; C1QBP; THBD

    Zhou, FF; Sun, RL; et al. Myostatin Gene Mutated Mice Induced with Tale Nucleases. ANIMAL BIOTECHNOLOGY 26:169-179(2015).
    Roslaniec, L; Jurkov, AS; et al. Design of Single-Switch Inverters for Variable Resistance/Load Modulation Operation. IEEE TRANSACTIONS ON POWER ELECTRONICS 30:3200-3214(2015).

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