Recombinant Human F7 therapeutic protein
Cat.No. : | F7-P042H |
Product Overview : | Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. It is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. The expression product is the active ingredient of Novoseven and Niastase. |
Source : | Hamster kidney cells |
Species : | Human |
Molecular Mass : | 45.1 kDa |
Protein length : | 406 aa |
AA Sequence : | ANAFLEELRPGSLERECKEEQCSFE EAREIFKDAERTKLFWISYSDGDQC ASSPCQNGGSCKDQLQSYICF CLPAFEGRNCETHKDDQLICVNENG GCEQYCSDHTGTKRSCRCHEGYSLL ADGVSCTPTVEYPCGKIPILE KRNASKPQGRIVGGKVCPKGECPWQ VLLLVNGAQLCGGTLINTIWVVSAA HCFDKIKNWRNLIAVLGEHDL SEHDGDEQSRRVAQVIIPSTYVPGT TNHDIALLRLHQPVVLTDHVVPLCL PERTFSERTLAFVRFSLVSGW GQLLDRGATALELMVLNVPRLMTQD CLQQSRKVGDSPNITEYMFCAGYSD GSKDSCKGDSGGPHATHYRGT WYLTGIVSWGQGCATVGHFGVYTRV SQYIEWLQKLMRSEPRPGVLLRAPF P |
Endotoxin : | < 0.1 EU per μg of the protein |
Purity : | >95% |
Storage : | Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles. |
Gene Name : | F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ] |
Official Symbol : | F7 |
Synonyms : | F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein; SPCA; proconvertin; serum prothrombin conversion accelerator; |
Gene ID : | 2155 |
mRNA Refseq : | NM_000131 |
Protein Refseq : | NP_000122 |
MIM : | 613878 |
UniProt ID : | P08709 |
Chromosome Location : | 13q34 |
Pathway : | BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Extrinsic Pathway, organism-specific biosystem; |
Function : | calcium ion binding; glycoprotein binding; peptidase activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity; |
Products Types
◆ Recombinant Protein | ||
F7-3622H | Recombinant Human F7 Protein, GST-tagged | +Inquiry |
F7-2602H | Recombinant Human F7 protein(71-210 aa), C-His-tagged | +Inquiry |
F7-959H | Recombinant Human F7 Protein, MYC/DDK-tagged | +Inquiry |
F7-1837R | Recombinant Rat F7 Protein, His (Fc)-Avi-tagged | +Inquiry |
F7-1357R | Recombinant Rhesus Macaque F7 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
F7-5303H | Native Human Coagulation Factor VII (serum prothrombin conversion accelerator) | +Inquiry |
◆ Lysates | ||
F7-1973HCL | Recombinant Human F7 cell lysate | +Inquiry |
F7-001MCL | Recombinant Mouse F7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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