"IFNA4" Related Products

Expand
Expand
Expand

Recombinant Human IFNA4 Protein, His-tagged

Cat.No.: IFNA4-432H
Product Overview: Recombinant Human IFNA4 (NP_066546.1) (Cys24-Asp189) was expressed with a polyhistidine tag at the C-terminus.
Description: Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
Source: Yeast
Species: Human
Tag : His
Predicted N Terminal: Cys 24
Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity: Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus. The ED50 for this effect is 2-10pg/mL.
Molecular Mass: The recombinant human IFNA4 consists of 176 amino acids and predicts a molecular mass of 20.8 kDa.
Protein length: Cys24-Asp189
Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
Purity: > 95 % as determined by SDS-PAGE.
Storage: Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name: IFNA4 interferon, alpha 4 [ Homo sapiens ]
Official Symbol: IFNA4
Synonyms: IFNA4; interferon, alpha 4; interferon alpha-4; IFN alpha4a; MGC142200; IFN-alpha-4; interferon alpha-4B; interferon alpha-76; interferon alpha-M1; INFA4; IFN-alpha4a;
Gene ID: 3441
mRNA Refseq: NM_021068
Protein Refseq: NP_066546
MIM: 147564
UniProt ID: P05014

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.