IFNA2
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Official Full Name
IFNA2 interferon, alpha 2
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Overview
Interferon alpha (IFN alpha) is a glycosylated protein which is produced by many cell types such as monocytes, macrophages, ?broblasts in response to virus infection, nucleic acid induction, glucocorticoid hormones. Some of the other biological effects, including antitumor and immunomodulatory activities IFN-alpha ’s most important function is the antiviral activity. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides. Some other biological processes involving IFN alpha are:induction of apoptosis, signal transduction, in?ammatory response. IFN alpha activates cytotoxic T-cells. IFN alpha binds to its receptors, which upon dimerisation, activate the JAK-STAT pathway. -
Synonyms
IFNA2; interferon, alpha 2; interferon alpha-2; alpha 2a interferon; IFN alphaA; IFNA; interferon alpha 2b; interferon alpha A; leIF A; IFN-alpha-2; alpha-2a interferon; INFA2; IFNA2B; IFN-alphaA; MGC125764; MGC125765;
- Recombinant Proteins
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Therapeutic Proteins
- Cell & Tissue Lysates
- Cynomolgus Monkey
- Feline
- Human
- Monkey
- Mouse
- Porcine
- Rat
- Rhesus
- Rhesus Macaque
- Barley Grain
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- Human Cell
- Human cells
- Mammalian Cell
- Mammalian cells
- Monkey
- Nicotiana Benthamiana
- Nicotiana Sp.
- P.pastoris
- Pseudomonas Putida
- S.cerevisiae
- Yeast
- Fc
- Flag
- GST
- HAS
- His
- Avi
- SUMO
- HQ
- HSA
- mFc
- Myc
- DDK
- N
- KSI
- MBP
- C
- Non
- StrepII
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IFNA2 involved in several pathways and played different roles in them. We selected most pathways IFNA2 participated on our site, such as Cytokine-cytokine receptor interaction, Regulation of autophagy, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | PDGFB;VEGFAA;PRLR;KDRL;LTBR;IL4R;XCL1;TNFRSF4;IL5 |
| Regulation of autophagy | Ifna11;ULK2;IFNA4;IFNA10;ATG12;ATG4B;IFNA17;ATG5;PRKAA2 |
| PIK-Akt signaling pathway | ITGA6;IFNA17;PKN1;PDGFA;NGFR;THBS3;EIF4E2;FGF11;PIK3CG |
| Toll-like receptor signaling pathway | MAP3K7;STAT1;PIK3R3B;CCL3L3;CCL3;IL-8;IFNA8;CCL3L1;IFNPHI3 |
| RIG-I-like receptor signaling pathway | TRAF3;CASP8;MAP3K7;PL10;DAK;IFNA8;IL8L1;MAP3K1;DDX58 |
| Cytosolic DNA-sensing pathway | IFNA10;IFNA8;PYCARD;NFKBIA;IKBKB;NFKBIB;MB21D1;IFNA2;CCL4 |
| Jak-STAT signaling pathway | PIAS1;JAK2A;IL29;HRASA;IL6R;PTPN11B;TYK2;GHR;IFNG1-2 |
| Natural killer cell mediated cytotoxicity | PIK3R3;RAC2;SHC2;PTPN6;IFNA1;SH2D1B;KLRC4-KLRK1;IFNA14;KLRC3 |
| Tuberculosis | ATP6V1H;CD209;MAPK1;NFYB;CALML3;RHOA;IL1A;IFNGR2;cgr2b |
| Hepatitis C | CLDN8;NFKB1;OAS1A;PPP2R1A;IRF7;KRAS;NFKBIA;PPP2CA;IFNAR2 |
| Hepatitis B | SMAD3;CCNA2;PTEN;STAT4;STAT5B;FOS;NFATC3;MAPK8;MAPK3 |
| Measles | IFNA14;CD3E;EIF2AK2;MX1;IL1A;CCND3;IFNA17;MYD88;IL13 |
| Influenza A | Fasl;HLA-DMA;EIF2AK1;OAS2;IFNB1;MAP2K7;MAP2K3;TYK2;MX1 |
| Herpes simplex infection | PPP1CAB;PER1A;SRSF2;CYCS;HCFC1;SRSF1B;RNASEL;SRSF5;OAS3 |
| Autoi | H2-Q10;HLA-DRB5;CD80;HLA-DOB;HLA-DPB1;IFNA13;Ifna11;IFNA16;H2-AA |
| ne thyroid disease | Fasl;IFNA8;IL4;IFNA5;HLA-DOB;HLA-DQA1;HLA-DQA2;HLA-F;H2-AB1 |
IFNA2 has several biochemical functions, for example, cytokine activity, protein binding, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA2 itself. We selected most functions IFNA2 had, and list some proteins which have the same functions with IFNA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GPI;TNF;CMTM8;GDF5;IFNA2;IFNA6;Il1f8;IL23;IL18 |
| protein binding | STAG3;CD244;PRICKLE1A;PYCARD;FBXW8;PHF10;CIAPIN1;AKAP13;AZIN1 |
| type I interferon receptor binding | Ifna15;GM13278;IFNA10;IFNA17;IFNPHI2;GM13285;IFNA12;GM13288;IFNK |
IFNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNA2.
IFNAR2
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