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IFNA21

Official Full Name

interferon, alpha 21
Overview

This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus.
Synonyms

IFNA21; interferon, alpha 21; interferon alpha-21; IFN alphaI; leukocyte interferon protein; Interferon alpha F; LeIF F; MGC126687; MGC126689; IFN-alpha-21; interferon alpha-F; leIF-F; IFN-alphaI;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
HEK293T
Spf Chicken Eggs
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IFNA21-77H	Recombinant Human Interferon, Alpha 21	E.coli	Non		Inquiry
Human	IFNA21-41H	Recombinant Human Interferon, Alpha 21	E.coli	Non		Inquiry
Human	IFNA21-140H	Recombinant Human Interferon, Alpha 21	Spf Chicken Eggs	Non		Inquiry
Human	IFNA21-5280HCL	Recombinant Human IFNA21 293 Cell Lysate	HEK293	Non		Inquiry
Human	IFNA21-6275H	Recombinant Human IFNA21 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	IFNA21-1424H	Recombinant Human IFNA21 Protein (24-189 aa), His-tagged	Yeast	His	24-189 aa	Inquiry
Human	IFNA21-617H	Recombinant Human IFNA21 Protein, His/GST-tagged	E.coli	His&GST	Asp25~Glu189	$298 / 10μg
Human	IFNA21-3100H	Recombinant Human IFNA21 Protein (Asp25-Glu189), N-GST tagged	E.coli	GST	Asp25-Glu189	Inquiry
Human	IFNA21-3069H	Recombinant Human IFNA21 protein, His-tagged	E.coli	His	24-189aa	Inquiry
Human	IFNA21-076H	Recombinant Human IFNA21 Protein	E.coli		24-189	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

IFNA21 involved in several pathways and played different roles in them. We selected most pathways IFNA21 participated on our site, such as Cytokine-cytokine receptor interaction, Regulation of autophagy, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNA21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	CCR6A;CCL1;IL7R;IL15;CXCL9;CCL3;KITLGA;CD70;KITB
Regulation of autophagy	IFNA14;IFNA8;ULK1;INS1;IFNG;PIK3R4;Ifna11;IFNA4;IFNA2
PIK-Akt signaling pathway	GNG13;RPS6KB1;FGF10;PKN1;ITGB1;FGFR3;BCL2L1;FGF7;HSP90AA1
Toll-like receptor signaling pathway	PIK3R3B;MAPK8;TAB2;MAPK11;IL12BA;SPP1;IL8L1;IRAK1;CASP8
RIG-I-like receptor signaling pathway	DAK;DDX3;TRAF3;IFNA3;NT5C3;TBK1;MAPK8A;RNF207B;RIPK1
Cytosolic DNA-sensing pathway	IFNA14;POLR3D;IFNA8;POLR2EB;POLR2E;IFNPHI3;POLR3C;POLR3K;IKBKE
Jak-STAT signaling pathway	Il23a;STAT3;IFNA2;MTOR;IL22RA1;PIAS4A;CRFB4;AOX1;AKT1
Natural killer cell mediated cytotoxicity	SH2D1A;NFATC1;NCR1;LCP2;Raet1a;IFNA7;IFNA17;RAF1;HLA-A
Tuberculosis	MAPK9;ATP6AP1;MAPK10;MAPK1;FADD;ARHGEF12;HLA-DRA;HLA-DQB1;HLA-DPB1
Hepatitis C	TNF;CLDN11;IFNA12;MAVS;SCARB1;PPP2CB;Ifna15;CLDN3;IRF9
Hepatitis B	BAD;CCNE2;IFNA21;IFNA12;Fasl;ELK1;MAP2K2;PIK3R1;IFNA6
Measles	IFNGR1;MSN;TAB2;SLAMF1;cgr2b;CD209;RCHY1;HSPA1B;RAB9B
Influenza A	NLRX1;EIF2AK2;TMPRSS4;CCL2;NXT2;IFNA14;TLR4;IL6;Ifna11
Herpes simplex infection	PER1A;HLA-DOA;IL12B;SRSF2A;CLOCKA;IFNA4;SRPK1;SRSF1B;IL1B
Autoi	HLA-DPB1;HLA-E;IL4;TPO;IL5;CD40LG;HLA-DQA1;HLA-DOA;TSHB
ne thyroid disease	HLA-DRB5;HLA-DPA1;HLA-DRB4;HLA-DOB;HLA-DOA;TSHR;HLA-DQB1;IFNA6;H2-AB1

IFNA21 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNA21 itself. We selected most functions IFNA21 had, and list some proteins which have the same functions with IFNA21. You can find most of the proteins on our site.

Function	Related Protein
cytokine activity	GM13278;IFNL3;BMP2;IL19;BMP7A;IL16;IFNE;TNFSF12;NDR2
cytokine receptor binding	IL17D;Ifna11;IL17C;IFNPHI2;IFNW1;IFNPHI3;IL17A/F1;IFNA8;IL17A/F2
type I interferon receptor binding	IFNA16;IFNA3;IFNA1;IFNA2;IFNA14;IFNA4;IFNA10;IFNA12;Ifnz

IFNA21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNA21 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNA21.

Research Area

Guo, YL; Gao, MC; et al. Molecular cloning and characterization of a novel bovine IFN-epsilon. GENE 558:25-30(2015).

Liu, R; Huang, DD; et al. Immunization with Recombinant SFTSV/NSs Protein Does Not Promote Virus Clearance in SFTSV-Infected C57BL/6J Mice. VIRAL IMMUNOLOGY 28:113-122(2015).