Recombinant Human SIRT2, His-tagged
Cat.No. : | SIRT2-2680H |
Product Overview : | Recombinant Human SIRT2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-352aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | SIRT2 sirtuin 2 [ Homo sapiens ] |
Official Symbol : | SIRT2 |
Synonyms : | SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491; |
Gene ID : | 22933 |
mRNA Refseq : | NM_030593 |
Protein Refseq : | NP_085096 |
MIM : | 604480 |
UniProt ID : | Q8IXJ6 |
Chromosome Location : | 19q13 |
Pathway : | Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem; |
Function : | NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; protein binding; protein deacetylase activity; trans |
Products Types
◆ Recombinant Protein | ||
SIRT2-23H | Recombinant Human SIRT2 Protein, His-tagged | +Inquiry |
SIRT2-31405TH | Active Recombinant Human SIRT2 Protein (50-356), C-6xHis tagged | +Inquiry |
SIRT2-107H | Recombinant Human SIRT2 Protein, His-tagged | +Inquiry |
SIRT2-8181M | Recombinant Mouse SIRT2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SIRT2-5067R | Recombinant Rat SIRT2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SIRT2-1834HCL | Recombinant Human SIRT2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2026 | SIRT2 Direct Fluorescent Screening Assay Kit | +Inquiry |
Kit-1083 | SIRT2 Inhibitor Screening Assay Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSIRT2 is involved in stress response pathways, deacetylating and modulating the activity of stress-responsive proteins, contributing to cellular adaptation to various stress conditions.
SIRT2 influences cellular metabolism by deacetylating enzymes involved in glycolysis, fatty acid metabolism, and mitochondrial function, impacting overall energy homeostasis.
SIRT2 uses NAD+ as a cofactor to remove acetyl groups from lysine residues, a process that links cellular metabolic state to protein acetylation and deacetylation.
SIRT2 influences cell cycle progression by deacetylating key regulators, such as cyclin-dependent kinases (CDKs) and checkpoint proteins, impacting cell cycle checkpoints and progression.
SIRT2 has been implicated in neurodegenerative diseases, and modulating its activity is explored as a potential therapeutic strategy for conditions such as Parkinson's disease.
Customer Reviews (3)
Write a reviewEfficient and knowledgeable customer service—made our purchase straightforward.
This recombined protein is our go-to for dependable and accurate results.
Punctual delivery is crucial, and this product arrived right on time.
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