Recombinant Human SEMA4D Protein, Fc-tagged

• Cat.No.: SEMA4D-440H
• Product Overview: Recombinant human SEMA4D protein with Fc tag was expressed in HEK293.

Specification

• Description: Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase signaling; regulation of neuron projection development; and regulation of phosphate metabolic process. Is integral component of plasma membrane.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 105.4 kDa
• Protein Length: 862
• AA Sequence: MRMCTPIRGLLMALAVMFGTAMAFA PIPRITWEHREVHLVQFHEPDIYNY SALLLSEDKDTLYIGAREAVFAVNA LNISEKQHEVYWKVSEDKKAKCAEK GKSKQTECLNYIRVLQPLSATSLYV CGTNAFQPACDHLNLTSFKFLGKNE DGKGRCPFDPAHSYTSVMVDGELYS GTSYNFLGSEPIISRNSSHSPLRTE YAIPWLNEPSFVFADVIRKSPDSPD GEDDRVYFFFTEVSVEYEFVFRVLI PRIARVCKGDQGGLRTLQKKWTSFL KARLICSRPDSGLVFNVLRDVFVLR SPGLKVPVFYALFTPQLNNVGLSAV CAYNLSTAEEVFSHGKYMQSTTVEQ SHTKWVRYNGPVPKPRPGACIDSEA RAANYTSSLNLPDKTLQFVKDHPLM DDSVTPIDNRPRLIKKDVNYTQIVV DRTQALDGTVYDVMFVSTDRGALHK AISLEHAVHIIEETQLFQDFEPVQT LLLSSKKGNRFVYAGSNSGVVQAPL AFCGKHGTCEDCVLARDPYCAWSPP TATCVALHQTESPSRGLIQEMSGDA SVCPDKSKGSYRQHFFKHGGTAELK CSQKSNLARVFWKFQNGVLKAESPK YGLMGRKNLLIFNLSEGDSGVYQCL SEERVKNKTVFQVVAKHVLEVKVVP KPVVAPTLSVVQTEGSRIATKVLVA STQGSSPPTPAVQATSSGAITLPPK PAPTGTSCEPKIVINTVPQLHSEKT MYLKSSDNRLLMSLFLFFFVLFLCL FFYNCYKGYLPRQCLKFRSALLIGK KKPKSDFCDREQSLKETLVEPGSFS QQNGEHPKPALDTGYETEQDTITSK VPTDREDSQRIDDLSARDKPFDVKC ELKFADSDADGD
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [ Homo sapiens (human) ]
• Official Symbol: SEMA4D
• Synonyms: SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; C9orf164, chromosome 9 open reading frame 164 , SEMAJ; semaphorin-4D; CD100; coll 4; FLJ39737; M sema G; A8; GR3; BB18; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; SEMAJ; coll-4; C9orf164; M-sema-G; FLJ33485; FLJ34282; FLJ46484; MGC169138; MGC169141
• Gene ID: 10507
• mRNA Refseq: NM_001142287
• Protein Refseq: NP_001135759
• MIM: 601866
• UniProt ID: Q92854