SEMA6D Protein

September 27-30, 2022

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SEMA6D

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SEMA6D

Official Full Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Background Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
Synonyms SEMA6D; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; semaphorin-6D; FLJ11598; KIAA1479; Q8NFY4; Semaphorin 6D
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEMA6D-841H Recombinant Human SEMA6D Protein, Fc Chimera Mammalian cells Fc
    Mouse Sema6d-877M Recombinant Mouse Sema6d Protein, Fc Chimera Mammalian cells Fc
    Zebrafish SEMA6D-12243Z Recombinant Zebrafish SEMA6D Mammalian Cell His
    Human SEMA6D-1583HCL Recombinant Human SEMA6D cell lysate N/A
    Human SEMA6D-956H Recombinant Human SEMA6D Protein, GST-tagged Wheat Germ GST

    SEMA6D involved in several pathways and played different roles in them. We selected most pathways SEMA6D participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA6D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance MYL12B; KDR; PPP3R1; DUSP1; MYL12A; PPP3CA; NTN1; MAPK1; EPHA1; FRS2

    SEMA6D has several biochemical functions, for example, chemorepellent activity, semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA6D itself. We selected most functions SEMA6D had, and list some proteins which have the same functions with SEMA6D. You can find most of the proteins on our site.

    Function Related Protein
    chemorepellent activity SEMA3G; SEMA3AB; EFNA5; SEMA4A; SEMA3FA; FLRT2; SEMA6A; SEMA3A; SEMA3D; SEMA3E
    semaphorin receptor binding SEMA4BA; SEMA4C; SEMA3B; SEMA3GA; SEMA6DL; SEMA6E; SH3BGRL3; SEMA3G; SEMA4B; SEMA4D

    SEMA6D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA6D here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA6D.

    Sambo, F; Malovini, A; et al. Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification. DIABETOLOGIA 57:1611-1622(2014).
    Matsuoka, RL; Sun, LO; et al. Sema6B, Sema6C, and Sema6D Expression and Function during Mammalian Retinal Development. PLOS ONE 8:-(2013).

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