SEMA6A
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Official Full Name
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
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Overview
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011] -
Synonyms
SEMA6A; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; VIA; SEMA; HT018; SEMAQ; SEMA6A1; semaphorin-6A; SEMA6A-1; sema VIa; semaphorin VIA; semaphorin 6A-1; semaphorin-6A-1;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SEMA6A-3885H | Recombinant Human SEMA6A protein, His-tagged | HEK293 | His | Met1-Thr649 | |
| Human | SEMA6A-2081HCL | Recombinant Human SEMA6A cell lysate | Human Cell | N/A |
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| Mouse | SEMA6A-14874M | Active Recombinant Mouse Sema6a Protein, Fc-tagged | Insect Cell | Fc |
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| Zebrafish | SEMA6A-10354Z | Recombinant Zebrafish SEMA6A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- SEMA6A Related Research Area
SEMA6A involved in several pathways and played different roles in them. We selected most pathways SEMA6A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EPHA2A;EPHB2;GNAI3;RHOGA;SDCBP;COL4A4;SEMA6D;SEMA4B;ITGB3A |
SEMA6A has several biochemical functions, for example, chemorepellent activity, protein binding, semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA6A itself. We selected most functions SEMA6A had, and list some proteins which have the same functions with SEMA6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemorepellent activity | SEMA6D;SEMA3C;SEMA3BL;SEMA5A;APOA1;SEMA4D;EFNA5;FLRT2;SEMA3B |
| protein binding | PIN4;MOXD1;DMAP1;CCDC108;CAV2;DHX32;WDFY3;RBM3;ROPN1B |
| semaphorin receptor binding | SEMA4A;SEMA4B;SEMA6C;SEMA3FA;SEMA4E;SEMA3GB;SEMA6D;SEMA3GA;SEMA5A |
SEMA6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA6A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA6A.
SMAD2; SORBS2; SH3RF1; SORBS1; ITSN2
- Q&As
- Reviews
Q&As (5)
Ask a questionSEMA6A protein levels or mutations could potentially be used as a diagnostic marker for neurodevelopmental disorders.
The interaction partners of SEMA6A may serve as potential pharmacological targets for the development of drugs aimed at modulating neuronal development.
While SEMA6A's primary role is in neuronal development, there is emerging evidence suggesting its involvement in adult neuroplasticity and neural remodeling.
Research into the precise role of SEMA6A in autism may lead to the development of targeted therapies aimed at correcting neuronal development abnormalities.
SEMA6A is known to interact with other proteins involved in axon guidance and neuronal migration, contributing to the intricate network of molecular pathways in the developing brain.
Customer Reviews (3)
Write a reviewthe SEMA6A protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.
Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.
Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.
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