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SEMA3A

  • Official Full Name

    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

  • Overview

    This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimers disease. [provided by RefSeq, Jul 2008]
  • Synonyms

    SEMA3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|Fc
  • His|T7
  • Flag
  • Met
  • 6
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SEMA3A-853H Recombinant Human SEMA3A Protein, His-tagged HEK293 His Asn21-Val771
Human SEMA3A-852H Recombinant Human SEMA3A protein, His/Fc-tagged HEK293 His/Fc Met 1-Val 771
Human SEMA3A-12H Recombinant Human SEMA3A, Fc-tagged Human Cell Fc
Human SEMA3A-1902H Recombinant Human SEMA3A protein, His-tagged E.coli His Pro580~Thr664
Human SEMA3A-13H Active Recombinant Human SEMA3A Protein, Met-6-His/Fc-tagged NS0 Met-6-His/Fc
Human SEMA3A-1901H Recombinant Human SEMA3A Protein, His-tagged E. coli His Arg31~Cys141
Human SEMA3A-0736H Active Recombinant Human SEMA3A protein, Fc-tagged HEK293 Fc Lys26-Val771
Human SEMA3A-3700H Recombinant Human SEMA3A protein, GST-tagged E.coli GST 140-235 aa
Human SEMA3A-5528H Recombinant Human SEMA3A Protein (Asn21-Val771), C-His tagged Mammalian cells C-His Asn21-Val771
Human SEMA3A-854H Recombinant Human SEMA3A, His-Flag-tagged HEK293 His-Flag Lys26-Phe546
Human SEMA3A-14H Active Recombinant Human SEMA3A protein, Fc-tagged HEK293 Fc Lys 26 - Val 771
Human SEMA3A-3850H Recombinant Human SEMA3A protein, His-tagged E.coli His 551-771 aa
Human SEMA3A-5527H Recombinant Human SEMA3A Protein (Lys26-His276), N-His tagged E.coli N-His Lys26-His276
Mouse Sema3a-908M Active Recombinant Mouse Sema3a Protein, Fc Chimera CHO Fc
Mouse Sema3a-7022M Recombinant Mouse Sema3a protein, His-tagged HEK293 His Lys26-Phe546
Mouse Sema3a-7021M Recombinant Mouse Sema3a protein(Lys26-Phe546), hFc-tagged HEK293 N-hFc Lys26-Phe546
Mouse SEMA3A-1770MCL Recombinant Mouse SEMA3A cell lysate Human Cell N/A
Mouse Sema3a-01M Active Recombinant Mouse Sema3a Protein, Fc-tagged CHO Fc
Mouse Sema3a-1904M Recombinant Mouse Sema3a protein, His & T7-tagged E.coli His/T7 Arg31~Pro150 (Accession # O08665)
Rat SEMA3A-5312R Recombinant Rat SEMA3A Protein Mammalian Cell His
Rat SEMA3A-1950R Recombinant Rat SEMA3A Protein (21-772 aa), His-tagged E.coli His 21-772 aa
Rat Sema3a-1905R Recombinant Rat Sema3a protein, His & T7-tagged E.coli His/T7 Arg31~Pro150 (Accession # Q63548)
Rat SEMA3A-4971R Recombinant Rat SEMA3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SEMA3A-4971R-B Recombinant Rat SEMA3A Protein Pre-coupled Magnetic Beads HEK293
Chicken SEMA3A-6536C Recombinant Chicken SEMA3A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SEMA3A Related Articles
  • SEMA3A Related Research Area

SEMA3A involved in several pathways and played different roles in them. We selected most pathways SEMA3A participated on our site, such as Axon guidance, CRMPs in Sema3A signaling, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidancePITPNA;LIMK2;DPYSL3;JAK2;SEMA3A;Sema3f;FGF20A;PHB;TRPC4
CRMPs in Sema3A signalingSEMA3AB;DPYSL2B;DPYSL5B;DPYSL5A;SEMA3A;DPYSL3;CDK5R1B;CDK5;CRMP1
Developmental BiologyFOXH1;NADL1.1;CDH4;CDK8;RGMB;NR6A1;MED10;MED25;DPYSL2
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionNRP1A;SEMA3AA;SEMA3A;SEMA3AB
Sema3A PAK dependent Axon repulsionSEMA3AB;SEMA3AA;SEMA3A;NRP1A
Semaphorin interactionsNRP1A;SEMA4D;DPYSL2;SEMA3A;DPYSL3;DPYSL5B;DPYSL5A;PLXND1;DPYSL4

SEMA3A has several biochemical functions, for example, chemorepellent activity, neuropilin binding, semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA3A itself. We selected most functions SEMA3A had, and list some proteins which have the same functions with SEMA3A. You can find most of the proteins on our site.

Function Related Protein
chemorepellent activitySEMA4BA;SEMA6D;SLIT2;SEMA3GA;SEMA3B;NRG3;EPHA7;SEMA6A;UBE4A
neuropilin bindingSEMA3A;SEMA3AB;SEMA7A;SEMA3B;SEMA3D;Sema3f;SEMA3E;SEMA4E;SEMA3BL
semaphorin receptor bindingSEMA5A;SEMA3E;SEMA3BL;SEMA4D;SEMA3GB;SEMA3D;SEMA3AB;SEMA3B;SEMA3G

SEMA3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA3A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA3A.

Venkova, K; Christov, A; et al. Semaphorin 3A Signaling Through Neuropilin-1 Is an Early Trigger for Distal Axonopathy in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 73:702-713(2014).
Vadasz, Z; Haj, T; et al. A regulatory role for CD72 expression on B cells in systemic lupus erythematosus. SEMINARS IN ARTHRITIS AND RHEUMATISM 43:767-771(2014).
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