|Official Full Name||sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F|
|Background||The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM, Mar 2008]|
|Synonyms||SEMA3F; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F; SEMA4; SEMAK; SEMA-IV; semaphorin-3F; sema IV; sema III/F; semaphorin IV; semaphorin III/F; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3F;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SEMA3F involved in several pathways and played different roles in them. We selected most pathways SEMA3F participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA3F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||PTPRA; NRTN; FRS3; DCX; CAP1; SRGAP1; SEMA3B; SEMA3G; SDCBP; PAQR3A|
SEMA3F has several biochemical functions, for example, chemorepellent activity, neuropilin binding, semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA3F itself. We selected most functions SEMA3F had, and list some proteins which have the same functions with SEMA3F. You can find most of the proteins on our site.
|chemorepellent activity||SEMA4C; NRG3; SEMA3E; SLIT2; UBE4A; SEMA3G; FLRT3; APOA1; SEMA3AB; Sema3f|
|neuropilin binding||SEMA3A; SEMA3D; SEMA3H; SEMA4E; SEMA3AB; SEMA7A; SEMA3B; Sema3f; SEMA3BL; SEMA3AA|
|semaphorin receptor binding||SEMA5B; SEMA3GB; SEMA3A; SEMA3B; SEMA3C; SEMA4C; SEMA6DL; SEMA4A; SEMA4B; SEMA6C|
SEMA3F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA3F here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA3F.