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Official Full Name sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Background This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
Synonyms SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; semF; SEMAF; semaphorin-5A; sema F; semaphorin F; semaphorin-F; semaphorin 5A;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEMA5A-1860HCL Recombinant Human SEMA5A cell lysate Human Cell N/A
    Human SEMA5A-234H Recombinant Human SEMA5A, Fc Chimera Mammalian cells Fc Chimera
    Human SEMA5A-3240H Recombinant Human SEMA5A, His tagged Human Cell His
    Human SEMA5A-3894H Recombinant Human SEMA5A, Fc tagged Human Cell Fc
    Human SEMA5A-4337H Recombinant Human SEMA5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SEMA5A-603H Recombinant Human SEMA5A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMA5A-3511H Recombinant Human SEMA5A, MIgG2a Fc-tagged CHO Fc
    Human SMA5A-3512H Recombinant Human SEMA5A, HIgG1 Fc-tagged CHO Fc
    Mouse SEMA5A-1310MCL Recombinant Mouse SEMA5A cell lysate Human Cell N/A
    Mouse Sema5a-5762M Recombinant Mouse Sema5a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Sema5a-617M Recombinant Mouse Sema5a Protein, Fc Chimera CHO Fc
    Mouse Sema5a-8692M Recombinant Mouse Sema5a, His tagged Human Cell His
    Rat SEMA5A-5314R Recombinant Rat SEMA5A Protein Mammalian Cell His
    Rhesus Macaque SEMA5A-4135R Recombinant Rhesus monkey SEMA5A Protein, His-tagged Mammalian Cell His
    Zebrafish SEMA5A-8267Z Recombinant Zebrafish SEMA5A Mammalian Cell His

    SEMA5A involved in several pathways and played different roles in them. We selected most pathways SEMA5A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    SEMA5A has several biochemical functions, for example, axon guidance receptor activity, chemorepellent activity, chondroitin sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA5A itself. We selected most functions SEMA5A had, and list some proteins which have the same functions with SEMA5A. You can find most of the proteins on our site.

    Function Related Protein
    axon guidance receptor activity ROBO2; EPHB3; EPHB1; ROBO1; SEMA5A; EPHA7; GFRA3
    chemorepellent activity SEMA4D; Sema3f; SLIT2; SEMA5A; APOA1; SEMA6D; SEMA3C; SEMA3AB; EPHA7; SEMA3FA
    chondroitin sulfate proteoglycan binding SEMA5A; COL20A1; PTN; PTPRF
    heparan sulfate proteoglycan binding Gpc2; GPC5; HPSE2; GPC5A; GPC1; HRG; SLIT2; ITGAM; UBE4A; COMP
    semaphorin receptor binding SEMA3G; SEMA3C; SEMA4A; SEMA3GB; SEMA3GA; SEMA5A; SEMA4BA; SEMA3BL; SEMA4C; SEMA4B
    syndecan binding HPSE; SEMA5A; TNC; SDCBP; CHRD

    SEMA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA5A.


    Goldberg, JL; Vargas, ME; et al. An oligodendrocyte lineage-specific semaphorin, sema5A, inhibits axon growth by retinal ganglion cells. JOURNAL OF NEUROSCIENCE 24:4989-4999(2004).
    Oster, SF; Bodeker, MO; et al. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. DEVELOPMENT 130:775-784(2003).

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