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Official Full Name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Background This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; semaphorin-4A; sema B; semaphorin-B; semaphorin 4A; SemB; Semab; AI132332
    • Species :
    • Human
    • Mouse
    • Source :
    • CHO
    • HEK293
    • HEK293T
    • Human Cell
    • Tag :
    • Fc
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEMA4A-1573H Recombinant Human SEMA4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SEMA4A-1979HCL Recombinant Human SEMA4A cell lysate Human Cell N/A
    Human SEMA4A-2066HCL Recombinant Human SEMA4A cell lysate Human Cell N/A
    Human SEMA4A-3925H Recombinant Human SEMA4A, Fc tagged Human Cell Fc
    Human SEMA4A-3926H Recombinant Human SEMA4A protein, His-tagged HEK293 His
    Human SEMA4A-594H Recombinant Human SEMA4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SEMA4A-7022H Recombinant Human Sema Domain, Immunoglobulin Domain(Ig), Transmembrane Domain(TM) And Short Cytoplasmic Domain,(semaphorin) 4A, His-tagged Human Cell His
    Mouse SEMA4A-14866M Recombinant Mouse Sema4a protein, His-tagged HEK293 His
    Mouse Sema4a-14867M Recombinant Mouse Sema4a protein, Fc-tagged CHO Fc
    Mouse Sema4a-4001M Recombinant Mouse Sema4a, HIgG1 Fc-tagged CHO Fc
    Mouse Sema4a-5758M Recombinant Mouse Sema4a Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SEMA4A involved in several pathways and played different roles in them. We selected most pathways SEMA4A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance LRRC4; SEMA4B; SCN2A; SEMA5A; EFNA1A; CNTN6; FRS2; SPTB; MYL12B; RAC3

    SEMA4A has several biochemical functions, for example, chemorepellent activity, NOT neuropilin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA4A itself. We selected most functions SEMA4A had, and list some proteins which have the same functions with SEMA4A. You can find most of the proteins on our site.

    Function Related Protein
    chemorepellent activity SEMA4B; SEMA4E; SEMA4C; SEMA6E; SLIT2; SEMA3AB; SEMA3G; SEMA3B; SEMA3C; Sema3f
    NOT neuropilin binding SEMA4A; SEMA4BA; SEMA4C; SEMA4B; SEMA4D
    protein binding CRY2; BTN2A2; HNRNPAB; CDC42EP5; HACE1; TXNDC5; BCL2L2; HAAO; PAM16; OCLN
    semaphorin receptor binding SEMA4C; SEMA5A; SH3BGRL3; SEMA3G; SEMA6DL; SEMA3C; SEMA4D; SEMA6E; SEMA3FA; SEMA4B

    SEMA4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA4A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA4A.


    Ishii, H; Kubo, T; et al. Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402:168-172(2010).
    Yukawa, K; Tanaka, T; et al. Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 16:115-118(2005).

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