SEMA4A

  • Official Full Name

    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

  • Overview

    This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; semaphorin-4A; sema B; semaphorin-B; semaphorin 4A; SemB; Semab; AI132332;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • CHO
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian cells
  • C
  • hFc
  • His
  • Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SEMA4A-7022H Active Recombinant Human Sema Domain, Immunoglobulin Domain(Ig), Transmembrane Domain(TM) And Short Cytoplasmic Domain,(semaphorin) 4A, His-tagged Human Cell His 663aa
Human SEMA4A-3925H Recombinant Human SEMA4A protein(Met1-His683), hFc-tagged HEK293 C-hFc Met1-His683
Human SEMA4A-3926H Recombinant Human SEMA4A protein, His-tagged HEK293 His Gly33-His683
Human SEMA4A-1979HCL Recombinant Human SEMA4A cell lysate Human Cell N/A
Human SEMA4A-2066HCL Recombinant Human SEMA4A cell lysate Human Cell N/A
Human SEMA4A-1573H Recombinant Human SEMA4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SEMA4A-439H Recombinant Human SEMA4A Protein, His-tagged HEK293 His 761
Human SEMA4A-6265H Recombinant Human SEMA4A Protein (Thr33-His682), C-His tagged Mammalian cells C-His Thr33-His682
Human SEMA4A-594H Recombinant Human SEMA4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Sema4a-4001M Active Recombinant Mouse Sema4a, HIgG1 Fc-tagged CHO Fc
Mouse SEMA4A-14866M Recombinant Mouse Sema4a protein, His-tagged HEK293 His Thr33-His682
Mouse Sema4a-14867M Recombinant Mouse Sema4a protein, Fc-tagged CHO Fc Met1-Gln676
Mouse Sema4a-5758M Recombinant Mouse Sema4a Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SEMA4A involved in several pathways and played different roles in them. We selected most pathways SEMA4A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceDPYSL5;CSF2;SEMA3E;RHOD;ADAM10;EPHA3;KIF4A;TRPC4;DUSP1

SEMA4A has several biochemical functions, for example, chemorepellent activity, NOT neuropilin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA4A itself. We selected most functions SEMA4A had, and list some proteins which have the same functions with SEMA4A. You can find most of the proteins on our site.

Function Related Protein
chemorepellent activitySEMA5A;SEMA4BA;SEMA4C;SEMA6C;SEMA3H;NRG3;SEMA6D;SEMA3AB;EFNA5
NOT neuropilin bindingSEMA4A;SEMA4B;SEMA4BA;SEMA4D;SEMA4C
protein bindingFAM161A;DDRGK1;LSM7;EYA4;BUB3;ATF7IP;CTSL1;HIST1H3D;LMF2
semaphorin receptor bindingSEMA3B;SEMA3BL;SEMA4B;SEMA4E;SEMA6A;Sema3f;SEMA4C;SEMA5A;SEMA3H

SEMA4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA4A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA4A.

PLXND1; PLXNB2; PLXNB1; PLXNB3; DDX54

Research Area

Related articles

Ishii, H; Kubo, T; et al. Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402:168-172(2010).
Yukawa, K; Tanaka, T; et al. Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 16:115-118(2005).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of altered SEMA4A activity on neurodegenerative and autoimmune diseases? 07/26/2022

Altered SEMA4A activity is associated with the progression of neurodegenerative and autoimmune conditions.

What potential therapeutic applications arise from targeting SEMA4A in neurological and immune disorders? 05/10/2022

Targeting SEMA4A offers potential for treating a range of neurological and immune-mediated disorders.

What role does SEMA4A play in immune regulation? 02/25/2022

SEMA4A is involved in immune system regulation, affecting immune cell activation and responses.

What is the primary role of SEMA4A in nervous system development? 12/22/2020

SEMA4A, a semaphorin, is crucial for guiding axon development and neural connectivity in the nervous system.

How does SEMA4A contribute to axon guidance? 11/18/2019

It plays a key role in directing axonal growth and neuronal network formation.

How does SEMA4A interact with other signaling molecules? 01/29/2018

SEMA4A works with various signaling pathways, coordinating developmental and immune processes.

How do genetic variations in SEMA4A affect neural and immune functions? 10/08/2017

Genetic changes in SEMA4A can lead to impairments in neural development and immune system functioning.

Customer Reviews (3)

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10/29/2022

    Swift and accurate service, dependable for data accuracy.

    05/22/2022

      Invaluable support for insights, a research game-changer.

      10/12/2019

        Reliable partner in experiments, boosts research efficiency.

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