SEMA7A

  • Official Full Name

    sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

  • Overview

    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • Synonyms

    SEMA7A; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A; Semal; CDw108; H-Sema-L; M-Sema-L; 2900057C09Rik; semaphorin-7A; sema L; sema K1; H-Sema K1; semaphorin-L; Semaphorin K1; semaphorin-K1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Fc
  • Flag
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SEMA7A-1031H Active Recombinant Human SEMA7A Protein, Fc Chimera Mammalian cells Fc
Human SEMA7A-6973H Recombinant Human SEMA7A protein, His & T7-tagged E.coli His/T7 Tyr242~Arg507 (Accession # O75326)
Human SEMA7A-1978HCL Recombinant Human SEMA7A 293 Cell Lysate HEK293 N/A
Human SEMA7A-110HFL Recombinant Full Length Human SEMA7A Protein, C-Flag-tagged Mammalian cells Flag
Human SEMA7A-1957H Recombinant Human SEMA7A Protein (45-648 aa), His-tagged Yeast His 45-648 aa
Human SEMA7A-141H-B Recombinant Human SEMA7A Protein Pre-coupled Magnetic Beads HEK293
Human SEMA7A-3753H Recombinant Human SEMA7A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SEMA7A-141H Recombinant Human SEMA7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SEMA7A-5216H Recombinant Human SEMA7A Protein (Met1-Ala648), C-His tagged Mammalian cells C-His Met1-Ala648
Mouse Sema7a-191M Active Recombinant Mouse Sema7a protein, Fc-tagged Mammalian cells Fc Gln45-Ala646
Mouse SEMA7A-14877M Recombinant Mouse SEMA7A Protein Mammalian Cell His
Mouse Sema7a-6974M Recombinant Mouse Sema7a protein, His-tagged E.coli His Arg318~Met566
Mouse SEMA7A-8012M-B Recombinant Mouse SEMA7A Protein Pre-coupled Magnetic Beads HEK293
Mouse Sema7a-110M-B Recombinant Mouse Sema7a Protein Pre-coupled Magnetic Beads HEK293
Mouse Sema7a-110M Recombinant Mouse Sema7a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sema7a-5763M Recombinant Mouse Sema7a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SEMA7A-8012M Recombinant Mouse SEMA7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey SEMA7A-1537R Recombinant Rhesus Monkey SEMA7A Protein HEK293 N/A
Rhesus Macaque SEMA7A-4137R Recombinant Rhesus monkey SEMA7A Protein, His-tagged Mammalian Cell His
Rhesus Macaque SEMA7A-3954R-B Recombinant Rhesus Macaque SEMA7A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SEMA7A-3954R Recombinant Rhesus Macaque SEMA7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SEMA7A-6486Z Recombinant Zebrafish SEMA7A Mammalian Cell His
Chicken SEMA7A-4473C Recombinant Chicken SEMA7A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SEMA7A involved in several pathways and played different roles in them. We selected most pathways SEMA7A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceDOCK1;NRP1A;FYN;DAB2IPB;Ntng2;SRGAP1;EFNA4;GNAI3;KCNQ3

SEMA7A has several biochemical functions, for example, NOT chemorepellent activity, integrin binding, neuropilin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA7A itself. We selected most functions SEMA7A had, and list some proteins which have the same functions with SEMA7A. You can find most of the proteins on our site.

Function Related Protein
NOT chemorepellent activity
integrin bindingACTN4;WISP1B;THBS1;MMP14;ADAM10;DMP1;ILK;CTGFA;ITGB1BP2
neuropilin bindingSEMA3FA;SEMA3A;SEMA3AB;SEMA3GB;SEMA3C;SEMA7A;SEMA3G;SEMA3D;SEMA3H
protein bindingPLXNB2;TBPL1;ADRM1;CCNG1;NOSIP;GGA1;MC4R;NUSAP1;PEX6
NOT semaphorin receptor binding

SEMA7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA7A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA7A.

PLXNC1; aerA; ABL1; FYN; NCK1; GRB2

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