Recombinant Human PLA2G12A, His-tagged

• Cat.No.: PLA2G12A-30734TH
• Product Overview: Recombinant mature full length protein, corresponding to amino acids 23-189 of the Human Phospholipase A2 XII precursor , with a 16 amino acid N-terminal His tag. 183 total amino acids.

Specification

• Description: Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.01M Tris buffer, pH 8.6
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MRGSHHHHHH GMASHMQEQA QTTDWRATLK TIRNGVHKIDTYLNAALDLL GGEDGLCQYK CSDGSKPFPR YGYKPSPPNGCGSPLFGVHL NIGIPSLTKC CNQHDRCYET CGKSKNDCDEEFQYCLSKIC RDVQKTLGLT QHVQACETTV ELLFDSVIHLGCKPYLDSQR AACRCHYEEK TDL

Gene Information

• Gene Name: PLA2G12A phospholipase A2, group XIIA [ Homo sapiens ]
• Official Symbol: PLA2G12A
• Synonyms: PLA2G12A; phospholipase A2, group XIIA; phospholipase A2, group XII , PLA2G12; group XIIA secretory phospholipase A2
• Gene ID: 81579
• mRNA Refseq: NM_030821
• Protein Refseq: NP_110448
• MIM: 611652
• Uniprot ID: Q9BZM1
• Chromosome Location: 4q25
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; Fat digestion and absorption, organism-specific biosystem
• Function: calcium ion binding; calcium-dependent phospholipase A2 activity; hydrolase activity