PLA2G4A
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Official Full Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
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Overview
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. -
Synonyms
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf21 Insect Cell
- Wheat Germ
- Flag
- Flag|His
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PLA2G4A Related Research Area
PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycerophospholipid metabolism | PLA2G2E;LPIN1;PPAP2D;PLA2G16;PCYT1A;PLA2G4D;AGPAT6;GPD1B;LCAT |
Ether lipid metabolism | PLA2G2D;GAL3ST1A;PPAP2B;PLA2G1B;PPAP2A;PLA2G4F;ENPP6;PAFAH1B3;PLA2G4AA |
Arachidonic acid metabolism | CYP4F2;EPHX2;PLA2G2D;GGT1A;PTGR1;PLA2G2F;PTGS2;PTGIS;GPX8 |
Linoleic acid metabolism | PLA2G5;PLA2G1B;CYP3A41B;PLA2G4A;PLA2G6;PLA2G4AA;DHRS13L1;PLA2G4F;CYP2P9 |
alpha-Linolenic acid metabolism | PLA2G4D;PLA2G5;PLA2G10;PLA2G4AA;PLA2G1B;PLA2G4A;FADS2;PLA2G12A;ACAA1A |
Metabolic pathways | EBP;PLCH2;B4GALT2;UQCR11;ALG10;NME2B.1;UQCRC1;ATP5B;ABP1 |
MAPK signaling pathway | FGF16;RAC1;Casp3;NLK2;RASA1;FGF6A;CACNB1;CACNB4A;MAP2K4 |
Ras signaling pathway | GNG7;RALB;RASSF1;RASGRP3;FGF12;PIK3R5;PLA2G10;PLA2G1B;CALM3 |
Phospholipase D signaling pathway | LPAR5;AGPAT5;PIK3CD;DGKZ;Adcy4;GRM2;AVPR1B;PDGFD;PLA2G4A |
Vascular smooth muscle contraction | MAP2K2;ADORA2AB;GNA11;PPP1R14AA;RAF1A;CALML5;PLA2G12A;PLA2G3;CALM1A |
VEGF signaling pathway | CDC42L;MAPK14A;VEGFAB;AKT2L;PIK3R3A;NFATC2;CASP9;MAPK11;MAPK13 |
Platelet activation | GNAI1;GP9;PRKACG;GNAI2;PTGS1;TBXA2R;ITPR1;FGG;GNAI3 |
Fc epsilon RI signaling pathway | RAC3;PLA2G4C;IL4;MAPK10;PIK3R5;IL3;INPP5D;RAF1;MS4A2 |
Fc gamma R-mediated phagocytosis | AMPH;LAT;BIN1;RPS6KB1;MAPK1;PRKCE;ASAP1;CFL2;PIK3CB |
Glutamatergic synapse | GNG8;PLCB4;MAPK1;PLCB3;GRIK2;GNAO1;GNB3;GNG10;GRIK1 |
Serotonergic synapse | ALOX12;CYP2J5;GABRB3;PLCB2;GNB4;GNAI2;ALOX8;CYP2C70;BRAF |
Long-term depression | GUCY1A3;MAPK3;GRID2;GNA13;CRHR1;GNAI2;IGF1R;GNAQ;GNAO1 |
Inflammatory mediator regulation of TRP channels | ACCN4;CYP2J6;MAPK10;ASIC1;PIK3R1;GNAQ;CALM3;HTR2C;CYP4A14 |
GnRH signaling pathway | GNAQ;ADCY1B;CACNA1C;PLA2G4A;MAP2K4;MAPK11;HRASA;PLA2G4AA;HRAS |
Ovarian steroidogenesis | STAR;HSD3B5;Adcy4;HSD3B6;PRKACG;IGF1;LHCGR;HSD17B7;LHB |
Oxytocin signaling pathway | GNAI1;MEF2C;CALM1;PRKAB2;PLCB3;EEF2K;RAF1;PPP1R12A;CACNG1 |
Choline metabolism in cancer | MAPK8;PIP5K1A;EIF4EBP1;PPAP2A;Pdgfa&Pdgfb;SLC22A3;PDGFD;MAPK1;MAPK3 |
PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | S100A10A;PCDH1GC5;HPGDS;DSG2.1;S100A8;PCDH1G22;CLGN;FBN1;PLA2G10 |
calcium-dependent phospholipase A2 activity | PLA2G12A;PLA2G1B;PLA2G3;PLA2G4A;PLA2G4B;PLA2G5;PLA2G2A;PLA2G4F |
calcium-dependent phospholipid binding | SYT15;CPNE3;SYT10;DOC2B;SYTL1;SYT3;ANXA3;ESYT2;ANXA2A |
lysophospholipase activity | PNPLA7;PNPLA6;PLA2G4F;PLA2G4AA;PNPLA7A;PNPLA8;ENPP2;LYPLAL1;PLA2G4B |
phospholipase A2 activity | PLA2G10;OC90;PLB1;PLA2G2D;LCAT;PLA2G4A;RARRES3;PLA2G2E;PNPLA3 |
PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.
ELF3; pi3p; Ccdc9; MYC; Eif3e
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