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PLA2G4A

  • Official Full Name

    phospholipase A2, group IVA (cytosolic, calcium-dependent)

  • Overview

    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
  • Synonyms

    PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • Wheat Germ
  • Flag
  • Flag|His
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLA2G4A-42H Active Recombinant Human PLA2G4A protein, FLAG/His-tagged Insect Cell Flag/His
Human PLA2G4A-752H Active Recombinant Human PLA2G4A Protein, His-tagged Sf21 Insect Cell His Met1-Ala749
Human PLA2G4A-557H Recombinant Human PLA2G4A, His-tagged E.coli His
Human PLA2G4A-30736TH Recombinant Human PLA2G4A Wheat Germ N/A 110 amino acids
Human PLA2G4A-526H Recombinant Human PLA2G4A protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLA2G4A-1752H Recombinant Human PLA2G4A, GST-tagged E.coli GST 1-350aa
Human PLA2G4A-3141HCL Recombinant Human PLA2G4A 293 Cell Lysate HEK293 N/A
Human PLA2G4A-4321HFL Recombinant Full Length Human PLA2G4A protein, Flag-tagged Mamanlian cells Flag
Human PLA2G4A-6078H Recombinant Human PLA2G4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PLA2G4A-4924H Recombinant Human PLA2G4A Protein (Met1-Ser178), N-His tagged E.coli N-His Met1-Ser178
Mouse PLA2G4A-12894M Recombinant Mouse PLA2G4A Protein Mammalian Cell His
Mouse PLA2G4A-6799M-B Recombinant Mouse PLA2G4A Protein Pre-coupled Magnetic Beads HEK293
Mouse PLA2G4A-12895M Recombinant Mouse PLA2G4A Protein, His-tagged E. coli His
Mouse PLA2G4A-6799M Recombinant Mouse PLA2G4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pla2g4a-4901M Recombinant Mouse Pla2g4a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken PLA2G4A-6974C Recombinant Chicken PLA2G4A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLA2G4A Related Research Area

PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismPLA2G2E;LPIN1;PPAP2D;PLA2G16;PCYT1A;PLA2G4D;AGPAT6;GPD1B;LCAT
Ether lipid metabolismPLA2G2D;GAL3ST1A;PPAP2B;PLA2G1B;PPAP2A;PLA2G4F;ENPP6;PAFAH1B3;PLA2G4AA
Arachidonic acid metabolismCYP4F2;EPHX2;PLA2G2D;GGT1A;PTGR1;PLA2G2F;PTGS2;PTGIS;GPX8
Linoleic acid metabolismPLA2G5;PLA2G1B;CYP3A41B;PLA2G4A;PLA2G6;PLA2G4AA;DHRS13L1;PLA2G4F;CYP2P9
alpha-Linolenic acid metabolismPLA2G4D;PLA2G5;PLA2G10;PLA2G4AA;PLA2G1B;PLA2G4A;FADS2;PLA2G12A;ACAA1A
Metabolic pathwaysEBP;PLCH2;B4GALT2;UQCR11;ALG10;NME2B.1;UQCRC1;ATP5B;ABP1
MAPK signaling pathwayFGF16;RAC1;Casp3;NLK2;RASA1;FGF6A;CACNB1;CACNB4A;MAP2K4
Ras signaling pathwayGNG7;RALB;RASSF1;RASGRP3;FGF12;PIK3R5;PLA2G10;PLA2G1B;CALM3
Phospholipase D signaling pathwayLPAR5;AGPAT5;PIK3CD;DGKZ;Adcy4;GRM2;AVPR1B;PDGFD;PLA2G4A
Vascular smooth muscle contractionMAP2K2;ADORA2AB;GNA11;PPP1R14AA;RAF1A;CALML5;PLA2G12A;PLA2G3;CALM1A
VEGF signaling pathwayCDC42L;MAPK14A;VEGFAB;AKT2L;PIK3R3A;NFATC2;CASP9;MAPK11;MAPK13
Platelet activationGNAI1;GP9;PRKACG;GNAI2;PTGS1;TBXA2R;ITPR1;FGG;GNAI3
Fc epsilon RI signaling pathwayRAC3;PLA2G4C;IL4;MAPK10;PIK3R5;IL3;INPP5D;RAF1;MS4A2
Fc gamma R-mediated phagocytosisAMPH;LAT;BIN1;RPS6KB1;MAPK1;PRKCE;ASAP1;CFL2;PIK3CB
Glutamatergic synapseGNG8;PLCB4;MAPK1;PLCB3;GRIK2;GNAO1;GNB3;GNG10;GRIK1
Serotonergic synapseALOX12;CYP2J5;GABRB3;PLCB2;GNB4;GNAI2;ALOX8;CYP2C70;BRAF
Long-term depressionGUCY1A3;MAPK3;GRID2;GNA13;CRHR1;GNAI2;IGF1R;GNAQ;GNAO1
Inflammatory mediator regulation of TRP channelsACCN4;CYP2J6;MAPK10;ASIC1;PIK3R1;GNAQ;CALM3;HTR2C;CYP4A14
GnRH signaling pathwayGNAQ;ADCY1B;CACNA1C;PLA2G4A;MAP2K4;MAPK11;HRASA;PLA2G4AA;HRAS
Ovarian steroidogenesisSTAR;HSD3B5;Adcy4;HSD3B6;PRKACG;IGF1;LHCGR;HSD17B7;LHB
Oxytocin signaling pathwayGNAI1;MEF2C;CALM1;PRKAB2;PLCB3;EEF2K;RAF1;PPP1R12A;CACNG1
Choline metabolism in cancerMAPK8;PIP5K1A;EIF4EBP1;PPAP2A;Pdgfa&Pdgfb;SLC22A3;PDGFD;MAPK1;MAPK3

PLA2G4A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingS100A10A;PCDH1GC5;HPGDS;DSG2.1;S100A8;PCDH1G22;CLGN;FBN1;PLA2G10
calcium-dependent phospholipase A2 activityPLA2G12A;PLA2G1B;PLA2G3;PLA2G4A;PLA2G4B;PLA2G5;PLA2G2A;PLA2G4F
calcium-dependent phospholipid bindingSYT15;CPNE3;SYT10;DOC2B;SYTL1;SYT3;ANXA3;ESYT2;ANXA2A
lysophospholipase activityPNPLA7;PNPLA6;PLA2G4F;PLA2G4AA;PNPLA7A;PNPLA8;ENPP2;LYPLAL1;PLA2G4B
phospholipase A2 activityPLA2G10;OC90;PLB1;PLA2G2D;LCAT;PLA2G4A;RARRES3;PLA2G2E;PNPLA3

PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.

ELF3; pi3p; Ccdc9; MYC; Eif3e

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