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Official Full Name phospholipase A2, group IVA (cytosolic, calcium-dependent)
Background This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Synonyms PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G4A-1752H Recombinant Human PLA2G4A, GST-tagged E.coli GST
    Human PLA2G4A-30736TH Recombinant Human PLA2G4A Wheat Germ N/A
    Human PLA2G4A-3141HCL Recombinant Human PLA2G4A 293 Cell Lysate HEK293 N/A
    Human PLA2G4A-42H Recombinant Human PLA2G4A protein, FLAG/His-tagged Insect Cell Flag/His
    Human PLA2G4A-526H Recombinant Human PLA2G4A protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLA2G4A-557H Recombinant Human PLA2G4A, His-tagged E.coli His
    Human PLA2G4A-6078H Recombinant Human PLA2G4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PLA2G4A-752H Recombinant Human PLA2G4A Protein, His-tagged Sf21 Insect Cell His
    Mouse PLA2G4A-12894M Recombinant Mouse PLA2G4A Protein Mammalian Cell His
    Mouse PLA2G4A-12895M Recombinant Mouse PLA2G4A Protein, His-tagged E. coli His
    Mouse Pla2g4a-4901M Recombinant Mouse Pla2g4a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Chicken PLA2G4A-6974C Recombinant Chicken PLA2G4A Mammalian Cell His

    pla2g4a involved in several pathways and played different roles in them. We selected most pathways pla2g4a participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with pla2g4a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism PTDSS2; PMT; GPCPD1; PCYT1AA; TESCA; LYCAT; AGPAT4; LPIN1; LPCAT2; CHPT1
    Ether lipid metabolism PLA2G2E; PLA2G16; PAFAH1B1A; PLA2G6; PLA2G3; PPAP2D; PLB1; PLA2G2F; CEPT1B; PLA2G7
    Arachidonic acid metabolism ALOX5A; PLA2G6; PLA2G12B; ALOX12B; AKR1C6; CYP2P7; LTC4S; AWAT2; FAAH2B; LTA4H
    Linoleic acid metabolism CYP2C39; CYP2C37; CYP2C19; DHRS13L1; CYP2J6; PLA2G4F; CYP2C38; PLA2G4D; CYP2C55; CYP2P10
    alpha-Linolenic acid metabolism ACAA1; PLA2G2D; PLA2G4A; PLA2G1B; PLA2G4F; ACOX3; PLA2G4C; FADS2; ACOX1; PLA2G4D
    Metabolic pathways XDH; UAP1; DGAT2; ALOX8; INPP4AB; SPAM1; PGS1; ADSS; POLA2; NT5M
    MAPK signaling pathway CACNA2D1A; MAPK12; MAPK13; PLA2G4A; FGF22; CACNA1G; FGF21; MAPK1; CDC42; CACNA1C
    Ras signaling pathway TBK1; PIK3CA; ELK1; RGL1; PLA2G6; FGF14; RAC2; PLA2G2A; RAP1B; MAPK10
    Phospholipase D signaling pathway RALB; GRM5; TSC1; PPAP2A; AGTR1A; CYTH4; LPAR4; PLCG1; LPAR2; MS4A2
    Vascular smooth muscle contraction GNA11; PRKACB; AGTR1B; PRKACBB; PLA2G2E; ADCY2B; RHOAD; ROCK2A; RHOAA; GNAQ
    VEGF signaling pathway PPP3R2; MAPK12B; PRKCBB; PRKCBA; RAF1; PLA2G4C; RAC1B; AKT3A; MAP2K2B; PLCG1
    Platelet activation GP5; GUCY1A3; ACTG1; PLCB1; PLCB2; GNAI3; PRKCI; PPP1R12A; F2RL3; PRKG2
    Fc epsilon RI signaling pathway AKT1; AKT2; MAP2K3; IL4; LCP2; PLA2G4F; MAP2K2; VAV3; INPP5D; SYK
    Fc gamma R-mediated phagocytosis INPPL1; SYK; PIK3CA; LIMK2; PIK3R2; PAK1; PRKCB; PRKCE; ARPC5L; PLCG1
    Glutamatergic synapse GNB2; PLD2; GNB3; GRM1; GNG8; PLA2G4D; GNGT1; GNAI2; GRM4; GNG13
    Serotonergic synapse GNG3; PRKACB; MAOA; HTR1F; HTR2B; HTR2A; GNG11; GABRB3; GNB2; GNG8
    Long-term depression PRKG1; GRM1; MAP2K2; MAPK1; PLCB4; NOS1; PLCB3; GRID2; GNA12; PLCB1
    Inflammatory mediator regulation of TRP channels CAMK2D; PRKCD; MAPK8; PLCB3; PLA2G4F; CALM1; PLCG2; NTRK1; PRKCA; HTR2A
    GnRH signaling pathway PLA2G4F; CAMK2G; CALM4; CALM3B; PLA2G4C; CALML3; GNA11A; PRKCA; ITPR1; EGFRA
    Ovarian steroidogenesis HSD17B1; ACOT2; FSHB; IGF1R; CYP2J6; HSD17B7; HSD3B2; PRKACG; AKR1C3; IGF1
    Oxytocin signaling pathway CALM3; CAMK4; GNAI3; PLA2G4A; PLCB1; GNAI2; PRKCB; ACTB; ITPR3; PRKAG2
    Choline metabolism in cancer DGKG; KRAS; PLA2G4A; PPAP2C; PLA2G4C; NRAS; MAPK1; DGKA; PDGFRA; RALGDS

    pla2g4a has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pla2g4a itself. We selected most functions pla2g4a had, and list some proteins which have the same functions with pla2g4a. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PCDH15A; RAB11FIP4A; CA; PCDH2AA15; PCDH2AC; CABP7; SLC25A25; PCDHB5; ANXA4; MGMT
    calcium-dependent phospholipase A2 activity PLA2G2A; PLA2G4B; PLA2G1B; PLA2G5; PLA2G4A; PLA2G12A; PLA2G3; PLA2G4F
    calcium-dependent phospholipid binding SYT5; DOC2D; ANXA3A; ANXA1C; C2CD4B; SYTL4; ANXA5A; ANXA13L; CCDC167; ANXA5
    lysophospholipase activity PNPLA6; PLB1; LGALS13; PLA2G4AA; PNPLA7A; LYPLAL1; PNPLA8; PLA2G15; LYPLA1; ASPG
    phospholipase A2 activity ABHD3; PLA2G2F; PLA2G12B; PLA2G4A; LCAT; PLA2G2A; PLA2G2E; PLA2G4AA; RARRES3; PLA2G10

    pla2g4a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pla2g4a here. Most of them are supplied by our site. Hope this information will be useful for your research of pla2g4a.

    ELF3; pi3p; Ccdc9; MYC; Eif3e

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