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Official Full Name phospholipase A2, group IVA (cytosolic, calcium-dependent)
Background This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Synonyms PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; cytosolic phospholipase A2; cPLA2 alpha; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; cPLA2-alpha; MGC126350
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G4A-1752H Recombinant Human PLA2G4A, GST-tagged E.coli GST
    Human PLA2G4A-30736TH Recombinant Human PLA2G4A Wheat Germ N/A
    Human PLA2G4A-3141HCL Recombinant Human PLA2G4A 293 Cell Lysate HEK293 N/A
    Human PLA2G4A-42H Recombinant Human PLA2G4A protein, FLAG/His-tagged Insect Cell Flag/His
    Human PLA2G4A-526H Recombinant Human PLA2G4A protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLA2G4A-557H Recombinant Human PLA2G4A, His-tagged E.coli His
    Human PLA2G4A-752H Recombinant Human PLA2G4A Protein, His-tagged Sf21 Insect Cell His
    Mouse PLA2G4A-12894M Recombinant Mouse PLA2G4A Protein Mammalian Cell His
    Mouse PLA2G4A-12895M Recombinant Mouse PLA2G4A Protein, His-tagged E. coli His
    Chicken PLA2G4A-6974C Recombinant Chicken PLA2G4A Mammalian Cell His

    pla2g4a involved in several pathways and played different roles in them. We selected most pathways pla2g4a participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with pla2g4a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism GPCPD1; PLA2G4A; PNPLA6; AGPAT5; PTDSS1A; LYPLA1; GPD2; AGXT2L1; PCYT1BA; CHKA
    Ether lipid metabolism GAL3ST1; PLA2G12A; PLA2G16; CEPT1B; PLA2G10; PLA2G4AA; PLD1; PLA2G2A; EPT1; PAFAH1B3
    Arachidonic acid metabolism CYP2AD3; ALOX15B; GPX6; AKR1C21; PLA2G4F; PLA2G4AA; CBR1L; CYP2P10; CYP2C45; CYP2N13
    Linoleic acid metabolism PLA2G2A; PLB1; CYP2C45; PLA2G3; PLA2G5; CYP3A41A; CYP2C8; CYP2P7; PLA2G4AA; PLA2G2E
    alpha-Linolenic acid metabolism PLA2G5; PLA2G6; PLA2G2A; ACOX1; ACAA1; PLA2G1B; PLA2G2F; FADS2; PLA2G10; PLA2G12A
    Metabolic pathways CYP4A14; ALOX8; NME2B.2; MTHFS; GKUP; NOS2A; AKR1B1; GMPPA; ADH2-1; DAO.1
    MAPK signaling pathway CACNG6A; MAP2K6; FGF21; MAPK8IP3; HSPA8; FGF10A; MAPK14A; LRRK2; AKT2L; NTRK2
    Ras signaling pathway GNG12; GNGT2; RALBP1; GRIN2A; MET; PLCG2; GRIN2B; PAK2; RASSF1; PRKCA
    Phospholipase D signaling pathway CYTH4; TSC1; GNAS; PLCB4; GRM8; MAPK1; PIP5K1C; FYN; SOS1; LPAR4
    Vascular smooth muscle contraction MAPK3; KCNMB3; BRAF; KCNMA1A; PPP1R12C; PLA2G2D; ADRA1BB; RAF1B; ITPR1; GUCY1A3
    VEGF signaling pathway PLA2G4A; MAPKAPK2; SPHK1; PTK2; PTK2AA; MAPK12A; KRAS; AKT1; PIK3CB; PRKCA
    Platelet activation ROCK2; ARHGEF12; VAMP8; GNAS; PIK3CD; GP5; PLA2G4F; COL24A1; VASP; SRC
    Fc epsilon RI signaling pathway SOS1; MAPK11; PLA2G4F; PIK3CG; GRB2; VAV3; LCP2; RAC2; FCER1G; HRAS
    Fc gamma R-mediated phagocytosis PPAP2C; MARCKSL1; PLA2G4A; WAS; ARF6; PRKCG; ASAP2; PLA2G4D; FCGR2A; PIK3CB
    Glutamatergic synapse GNAS; PLA2G4D; PLCB3; SLC1A7; SLC38A3; GLUL; PLD2; GRM7; MAPK3; SLC1A1
    Serotonergic synapse MAOA; ITPR3; HTR4; PRKACG; CYP2J5; GNAS; GNAO1; Casp3; HTR2B; MAPK3
    Long-term depression GNAS; PPP2R1B; IGF1; PRKCA; PLA2G4D; PRKG1; RYR1; PRKCB; NOS1; IGF1R
    Inflammatory mediator regulation of TRP channels ASIC2; PRKCA; CALML5; CYP2J2; PLA2G4C; CALM1; GNAQ; PLCG2; Adcy4; PPP1CB
    GnRH signaling pathway PTK2BB; MAPK11; CALM1B; CAMK2G; PLD2; MAP2K6; MAPK8A; HRASB; GNRHR4; CALML3
    Ovarian steroidogenesis GNAS; HSD3B5; STAR; AKR1C3; CYP2J5; PTGS2; BMP6; HSD3B4; CYP2J6; INS
    Oxytocin signaling pathway KRAS; ACTG1; PRKAB1; PPP3CC; RCAN1; NPR1; ITPR3; KCNJ14; PIK3CA; ROCK2
    Choline metabolism in cancer RHEB; NRAS; PIK3CD; DGKZ; PPAP2B; PIK3CB; PDGFD; MAPK9; PIK3CG; KRAS

    pla2g4a has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pla2g4a itself. We selected most functions pla2g4a had, and list some proteins which have the same functions with pla2g4a. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding RYR3; CAPN3; SYT5B; ACTN3B; FSTL4; SLIT1B; NUCB2; TLL1; FBLN1; SLIT2
    calcium-dependent phospholipase A2 activity PLA2G3; PLA2G2A; PLA2G4B; PLA2G4A; PLA2G4F; PLA2G12A; PLA2G5; PLA2G1B
    calcium-dependent phospholipid binding ANXA1A; SYT7; SYT12; SYT9; ANXA8; SYT1B; ANXA4; ANXA5B; RPH3AL; ANXA5A
    lysophospholipase activity PLB1; LYPLAL1; LGALS13; Cel; PLA2G4A; PNPLA7A; ENPP2; PLA2G15; PNPLA8; MGLL
    phospholipase A2 activity PLA2G6; LCAT; PLA2G4A; PLA2G2A; PLB1; PLA2G10; PLA2G2F; PLA2G2E; RARRES3; ABHD3

    pla2g4a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pla2g4a here. Most of them are supplied by our site. Hope this information will be useful for your research of pla2g4a.

    ELF3; pi3p; Ccdc9; MYC; Eif3e

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