PLA2G2D

  • Official Full Name

    phospholipase A2, group IID
  • Overview

    Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
  • Synonyms

    PLA2G2D;phospholipase A2, group IID;group IID secretory phospholipase A2;sPLA2S;PLA2IID;sPLA2-IID;GIID sPLA2;secretory phospholipase A2s;phosphatidylcholine 2-acylhydrolase 2D;secretory-type PLA, stroma-associated homolog;SPLASH

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • E.coli
  • Human Cells
  • HEK293
  • His
  • Non
  • T7
  • Fc
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
Pla2g2d-489M Recombinant Mouse PLA2G2D, His tagged E.coli Mouse His
PLA2G2D-8493H Recombinant Human PLA2G2D Protein E.coli Human Non
Pla2g2d-1477R Recombinant Rat Pla2g2d protein, His & T7-tagged E.coli Rat His&T7 Gly20~Arg134
PLA2G2D-365H Recombinant Human PLA2G2D, Fc-tagged Human Cells Human Fc Met1-Cys145
PLA2G2D-757HCL Recombinant Human PLA2G2D cell lysate Human Cells Human Non
PLA2G2D-4185H Recombinant Human PLA2G2D Protein (Gly21-Cys145), N-His tagged E.coli Human His Gly21-Cys145
PLA2G2D-4944H Recombinant Human PLA2G2D protein, His-SUMO-tagged E.coli Human His&SUMO 22-145aa
PLA2G2D-902M Recombinant Mouse PLA2G2D Protein (Met1-Cys144), HlgG1 Fc-tagged HEK293 Mouse Fc Met1-Cys144

    Involved Pathway

    PLA2G2D involved in several pathways and played different roles in them. We selected most pathways PLA2G2D participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway KLK1B4,IGF1,PLD2,RAB5B,KIT,FGF4,SHC2,FGF5,PLA2G2E,CALM3
    Pancreatic secretion PNLIPRP2,PLA2G3,RAP1A,PNLIP,CLCA1,FXYD2,PLA2G12A,PRSS3,CTRL,PLCB1
    Linoleic acid metabolism PLA2G6,PLA2G2E,PLA2G12B,PLA2G4F,CYP2C38,CYP2C39,CYP2J6,CYP2C55,CYP2P10,PLA2G2F
    Metabolic pathways ALDH3B2,PIGYL,PLCD1B,DNMT3AA,GPT2L,ALPI.2,CES1C,DHRS9,ACSS1,AANAT
    Glycerophospholipid metabolism PLA2G3,GPD1B,LPIN2,GPD1,PLD1A,CHKA,MBOAT2,MBOAT2B,TESCA,CDS2
    Fat digestion and absorption PPAP2A,MOGAT3,PPAP2B,PLA2G12A,PNLIPRP2,PLA2G5,CD36,FABP2,MOGAT2,DGAT1
    Arachidonic acid metabolism CYP4A11,FAAH2B,GPX8,GGT5,PLA2G2A,ALOX15,CBR2,ALOX5AP,PTGES3A,CYP4F18
    Vascular smooth muscle contraction GNA11B,MYLK3,AGTR1B,PLA2G1B,CALM4,CACNA1D,PPP1R14A,KCNMB2,RHOAB,ARHGEF1
    alpha-Linolenic acid metabolism ACOX3,PLA2G10,FADS2,PLA2G2A,PLA2G1B,PLA2G12A,PLA2G12B,PLA2G3,ACOX1,PLA2G4AA

    Protein Function

    PLA2G2D has several biochemical functions, for example, calcium ion binding,heparan sulfate proteoglycan binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2D itself. We selected most functions PLA2G2D had, and list some proteins which have the same functions with PLA2G2D. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CAPSLA,ANXA6,PLA2G2F,PRRG3,SYT6,CABP1B,PLCD1,SLC24A4,PCDH2AA3,ELTD1
    heparan sulfate proteoglycan binding HPSE2,CFH,GPC4,HRG,AZU1,GPC5,GPC6A,AGRN,ITGAM,GPC6
    heparin binding SLIT1A,FGF4,FGF10,SERPINA5,FGF9,PF4,APPB,SELP,NRP1A,PRG2
    phospholipase A2 activity PLA2G10,LCAT,PRDX6,PLB1,PLA2G4A,OC90,PLA2G4AA,PLA2G2A,PLA2G2F,PLA2G16

    Interacting Protein

    PLA2G2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2D here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2D.

    Resources

    References

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