PLA2G2D
-
Official Full Name
phospholipase A2, group IID -
Overview
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids. -
Synonyms
PLA2G2D;phospholipase A2, group IID;group IID secretory phospholipase A2;sPLA2S;PLA2IID;sPLA2-IID;GIID sPLA2;secretory phospholipase A2s;phosphatidylcholine 2-acylhydrolase 2D;secretory-type PLA, stroma-associated homolog;SPLASH
Recombinant Proteins
- Mouse
- Human
- Rat
- E.coli
- Human Cells
- HEK293
- His
- Non
- T7
- Fc
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Pla2g2d-489M | Recombinant Mouse PLA2G2D, His tagged | E.coli | Mouse | His | ||
| PLA2G2D-8493H | Recombinant Human PLA2G2D Protein | E.coli | Human | Non | ||
| Pla2g2d-1477R | Recombinant Rat Pla2g2d protein, His & T7-tagged | E.coli | Rat | His&T7 | Gly20~Arg134 |
|
| PLA2G2D-365H | Recombinant Human PLA2G2D, Fc-tagged | Human Cells | Human | Fc | Met1-Cys145 |
|
| PLA2G2D-757HCL | Recombinant Human PLA2G2D cell lysate | Human Cells | Human | Non |
|
|
| PLA2G2D-4185H | Recombinant Human PLA2G2D Protein (Gly21-Cys145), N-His tagged | E.coli | Human | His | Gly21-Cys145 |
|
| PLA2G2D-4944H | Recombinant Human PLA2G2D protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 22-145aa |
|
| PLA2G2D-902M | Recombinant Mouse PLA2G2D Protein (Met1-Cys144), HlgG1 Fc-tagged | HEK293 | Mouse | Fc | Met1-Cys144 |
|
Involved Pathway
PLA2G2D involved in several pathways and played different roles in them. We selected most pathways PLA2G2D participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ether lipid metabolism | PLD2,PLA2G16,PLA2G4C,PLA2G2F,PLD1,PLA2G12B,PLA2G5,PAFAH1B1A,LPCAT1,CHPT1 |
| alpha-Linolenic acid metabolism | PLA2G10,PLA2G5,ACOX1,PLA2G4C,ACOX3,ACAA1A,PLA2G6,PLA2G4A,PLA2G2E,PLA2G4D |
| Vascular smooth muscle contraction | RHOAC,PLA2G12A,PRKG1,PRKCDA,PRKCBA,PRKACBB,PPP1CBL,PRKCH,EDNRAA,ROCK2A |
| Glycerophospholipid metabolism | PLA2G4C,PPAP2C,LCAT,PLA2G12A,AGPAT4,PHYKPL,LCLAT1,AGPAT9,PLA2G4AA,PPAP2B |
| Metabolic pathways | DAD1,CYP17A1,C1GALT1C1,POLR3H,ASMT,DAO.2,CHKA,GATC,POC1B-GALNT4,CMBL |
| Ras signaling pathway | ETS2,NFKB1,REL,PRKCB,RASSF1,FGFR2,RALBP1,ANGPT4,FLT1,GNB1 |
| Arachidonic acid metabolism | CYP2P6,CBR3,CYP2P8,CYP2P9,CYP2C70,PTGIS,PLA2G4A,CYP2B6,ALOX15B,CYP2J6 |
| Linoleic acid metabolism | PLA2G3,CYP2J2,CYP3A25,CYP2C45,PLA2G12A,PLA2G2E,CYP3A65,CYP2C37,PLA2G6,PLB1 |
| Pancreatic secretion | PRKCA,SLC9A1,CPB1,PLA2G2A,PLA2G3,ATP1A2,CELA3B,FXYD2,CELA2A,CTRL |
Protein Function
PLA2G2D has several biochemical functions, for example, calcium ion binding,heparan sulfate proteoglycan binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2D itself. We selected most functions PLA2G2D had, and list some proteins which have the same functions with PLA2G2D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparan sulfate proteoglycan binding | GPC6,SLIT2,GPC6A,UBE4A,GPC5A,ITGAM,GPC5,GPC4,AZU1,GPC1A |
| calcium ion binding | SPARC,PLCH2,SERPINB1A,S100S,MELK,EYS,MEX3B,CABP7,GAS6,NUCB1 |
| phospholipase A2 activity | PRDX6,PLA2G12B,OC90,PLA2G16,RARRES3,PLB1,PLA2G2E,PLA2G1B,PLA2G10,PLA2G2A |
| heparin binding | CTGFB,SAA1,MSTN,SOST,GM4980,WISP2,FGFR1,THBS4,NRP1A,FGF9 |
Interacting Protein
PLA2G2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2D here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2D.
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