PLA2G5

  • Official Full Name

    phospholipase A2, group V

  • Overview

    This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

  • Synonyms

    PLA2G5;phospholipase A2, group V;calcium-dependent phospholipase A2;Ca2+ dependent phospholipase A2;Calcium dependent phospholipase A2;DKFZp686C2294;Group V phospholipase A2;GV PLA2;gVPLA2;hVPLA(2);MGC46205;OTTHUMP00000044655;PA2G5_HUMAN;Phosphatidylcholine 2 acylhydrolase;Phosphatidylcholine 2-acylhydrolase 5;Phospholipase A2 group V;PLA2 10;PLA2 G5;PLA2-10;sPLA2 Type V;OTTHUMP00000002785;Ca2+-dependent phospholipase A2;GV-PLA2

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • Mammalian Cells
  • E.coli
  • Yeast
  • HEK293
  • His
  • SUMO
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PLA2G5-12900M Recombinant Mouse PLA2G5 Protein Mammalian Cells Mouse His
PLA2G5-31349TH Recombinant Human PLA2G5, His-tagged E.coli Human His Full L. 21-138 a.a.
PLA2G5-3455R Recombinant Rhesus monkey PLA2G5 Protein, His-tagged Mammalian Cells Rhesus macaque His
PLA2G5-4490R Recombinant Rat PLA2G5 Protein Mammalian Cells Rat His
PLA2G5-5325C Recombinant Chicken PLA2G5 Mammalian Cells Chicken His
PLA2G5-71H Recombinant Human Phospholipase A2, Group V, His-tagged E.coli Human His
Pla2g5-1412M Recombinant Mouse Pla2g5 Protein, His-SUMO-tagged E.coli Mouse His&SUMO 21-137 a.a.
PLA2G5-1487H Recombinant Human PLA2G5 Protein (21-138 aa), His-tagged Yeast Human His 21-138 aa
PLA2G5-161H Recombinant Human PLA2G5 Protein E.coli Human
PLA2G5-3273R Recombinant Rhesus Macaque PLA2G5 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
PLA2G5-3273R-B Recombinant Rhesus Macaque PLA2G5 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PLA2G5-4150R Recombinant Rat PLA2G5 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PLA2G5-4150R-B Recombinant Rat PLA2G5 Protein Pre-coupled Magnetic Beads HEK293 Rat
PLA2G5-44H Recombinant Human PLA2G5 Protein E.coli Human
PLA2G5-6802M Recombinant Mouse PLA2G5 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PLA2G5-6802M-B Recombinant Mouse PLA2G5 Protein Pre-coupled Magnetic Beads HEK293 Mouse
PLA2G5-722R Recombinant Rat PLA2G5 Protein (21-137 aa), His-SUMO-tagged E.coli Rat His&SUMO 21-137 aa

    Involved Pathway

    PLA2G5 involved in several pathways and played different roles in them. We selected most pathways PLA2G5 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways ST8SIA1,ADI1,CYP51,AANAT2,CEPT1,PLCD3A,ATP6V0A2,HADH,UOX,NDST3
    Pancreatic secretion CTRL,CLCA4,ATP2B1,ATP2A1,CPB2,ATP2A2,GNAQ,PLA2G2D,PNLIPRP2,CCKAR
    Ether lipid metabolism PLA2G16,PLA2G4A,LPCAT2,PLA2G2F,PLA2G10,LPCAT4,PAFAH1B3,PLA2G2A,GAL3ST1,CHPT1
    Linoleic acid metabolism CYP2C70,PLA2G4A,DHRS13L1,CYP2P8,PLA2G4AA,PLA2G2E,CYP2P6,PLB1,PLA2G12B,CYP2C55
    Vascular smooth muscle contraction MYLK4,MAPK1,CALM3,ACTA2,PRKCBA,PLA2G6,PPP1R12B,PRKCHA,PRKACB,GNA11
    Arachidonic acid metabolism PLA2G6,GPX1A,FAAH2A,CYP4F3,CYP2C39,PTGS2A,PLA2G16,GPX2,CYP2AD2,CYP4F2
    Glycerophospholipid metabolism PLD4,PLA2G4F,DGKD,GPAM,TESCA,ETNPPL,PHYKPL,TAZ,MBOAT1,PISD
    Ras signaling pathway FGF21,PIK3R2,KRAS,Fasl,GRIN2B,IGF1R,RIN1,Pdgfa&Pdgfb,SHC2,FGFR4
    alpha-Linolenic acid metabolism ACOX3,PLA2G2A,PLA2G12B,PLA2G12A,ACAA1,ACAA1A,ACOX1,PLA2G2E,PLA2G4C,PLA2G4D

    Protein Function

    PLA2G5 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipase A2 activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G5 itself. We selected most functions PLA2G5 had, and list some proteins which have the same functions with PLA2G5. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CD97,EDEM1,MAN1B1,PPP3R1,CUBN,PCDH1G26,CDK5R1,OVAL,CBLB,DGKAA
    heparin binding SOST,CXCL13,LIPH,CYR61L1,SMOC2,THBS1,CCL5,FGF14,CCL15,CTGFA
    calcium-dependent phospholipase A2 activity PLA2G2A,PLA2G1B,PLA2G4F,PLA2G3,PLA2G12A,PLA2G4B,PLA2G4A

    Interacting Protein

    PLA2G5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G5.

    Resources

    References

    • Xue, ML; Shen, K; et al. Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A(2). ARTHRITIS RESEARCH & THERAPY 16:-(2014).
    • Meliton, AY; Munoz, NM; et al. Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304:L689-L700(2013).

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