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Official Full Name phospholipase A2, group V
Background This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
Synonyms PLA2G5; phospholipase A2, group V; calcium-dependent phospholipase A2; Ca2+ dependent phospholipase A2; Calcium dependent phospholipase A2; DKFZp686C2294; Group V phospholipase A2; GV PLA2; gVPLA2; hVPLA(2); MGC46205; OTTHUMP00000044655; PA2G5_HUMAN; Phosphatidylcholine 2 acylhydrolase; Phosphatidylcholine 2-acylhydrolase 5; Phospholipase A2 group V; PLA2 10; PLA2 G5; PLA2-10; sPLA2 Type V; OTTHUMP00000002785; Ca2+-dependent phospholipase A2; GV-PLA2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G5-1487H Recombinant Human PLA2G5 Protein (21-138 aa), His-tagged Yeast His
    Human PLA2G5-31349TH Recombinant Human PLA2G5, His-tagged E.coli His
    Human PLA2G5-44H Recombinant Human PLA2G5 Protein E.coli
    Human PLA2G5-71H Recombinant Human Phospholipase A2, Group V, His-tagged E.coli His
    Mouse PLA2G5-12900M Recombinant Mouse PLA2G5 Protein Mammalian Cell His
    Mouse Pla2g5-1412M Recombinant Mouse Pla2g5 Protein, His-SUMO-tagged E.coli His/SUMO
    Rat PLA2G5-4490R Recombinant Rat PLA2G5 Protein Mammalian Cell His
    Rat PLA2G5-722R Recombinant Rat PLA2G5 Protein (21-137 aa), His-SUMO-tagged E.coli His/SUMO
    Rhesus Macaque PLA2G5-3455R Recombinant Rhesus monkey PLA2G5 Protein, His-tagged Mammalian Cell His
    Chicken PLA2G5-5325C Recombinant Chicken PLA2G5 Mammalian Cell His

    pla2g5 involved in several pathways and played different roles in them. We selected most pathways pla2g5 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with pla2g5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism CDS1; DGKD; GNPAT; PLA2G5; CHKA; LPCAT1; LPCAT3; DGKAA; GPD1L; PHYKPL
    Ether lipid metabolism PLA2G2F; PPAP2A; PAFAH1B1; PLA2G4A; PLB1; PPAP2B; PPAP2D; PLA2G4D; PLA2G7; LPCAT4
    Arachidonic acid metabolism PTGES3A; PLA2G4C; PLA2G2E; PTGES; CYP2AD2; CBR1L; AKR1C3; CYP2B6; CYP2P9; GPX6
    Linoleic acid metabolism CYP3A25; PLA2G10; CYP2C39; PLA2G12B; PLA2G12A; CYP2C37; CYP3A41B; PLA2G6; CYP2C8; PLA2G5
    alpha-Linolenic acid metabolism PLA2G12B; PLA2G2D; ACOX1; PLA2G1B; ACOX3; ACAA1A; FADS2; PLA2G12A; PLA2G10; ACAA1
    Metabolic pathways CYP3A41B; IMPA2; DPM1; DAO; ACSL1; NAGS; OGDHL; AKR1A1A; MTMR1B; SQLE
    Ras signaling pathway RAC1; GNB3; ANGPT2; FGF4; GAB2; INS; TEK; FGF10; PDGFD; PLA2G2E
    Vascular smooth muscle contraction PRKCG; PRKCDA; EDNRAA; PLA2G4F; GNA15.1; AGTR1B; MLCK2; NPR1; PPP1R12A; NPR1A
    Pancreatic secretion CLCA5; Car2; CELA3A; CPA2; KCNMA1; GNAQ; ATP2B1; PLA2G10; SCTR; CPA3
    Fat digestion and absorption CD36; PLA2G2F; PLA2G5; APOA1; PLA2G1B; GOT2; FABP2; AGPAT2; PNLIPRP2; PPAP2B

    pla2g5 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pla2g5 itself. We selected most functions pla2g5 had, and list some proteins which have the same functions with pla2g5. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PCDH2AB9; THBS4A; SPOCK2; EPS15; PCDH19; MAN1C1; PCDHB2; PCDH1G29; NCS1A; CRNN
    calcium-dependent phospholipase A2 activity PLA2G1B; PLA2G4F; PLA2G2A; PLA2G3; PLA2G12A; PLA2G4A; PLA2G4B; PLA2G5

    pla2g5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pla2g5 here. Most of them are supplied by our site. Hope this information will be useful for your research of pla2g5.

    Xue, ML; Shen, K; et al. Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A(2). ARTHRITIS RESEARCH & THERAPY 16:-(2014).
    Meliton, AY; Munoz, NM; et al. Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304:L689-L700(2013).

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