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Pla2g12b

Official Full Name

phospholipase A2, group XIIB
Overview

Mouse Group XIIB secretory phospholipase A2-like protein, also knownas Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and Pla2g12b, is a secreted protein which belongs to the phospholipase A2 family. Pla2g12b / PLA2G13 is strong expression in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids.
Synonyms

GXIIB; FKSG71; PLA2G13; GXIIIsPLA2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLA2G12B-1880H	Recombinant Human PLA2G12B Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	Pla2g12b-1192M	Recombinant Mouse Pla2g12b protein, His-tagged	HEK293	His	Met1-Leu195	Inquiry
Mouse	PLA2G12B-1866MCL	Recombinant Mouse PLA2G12B cell lysate	Human Cell	N/A		Inquiry
Mouse	Pla2g12b-4896M	Recombinant Mouse Pla2g12b Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	PLA2G12B-12601Z	Recombinant Zebrafish PLA2G12B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

Pla2g12b involved in several pathways and played different roles in them. We selected most pathways Pla2g12b participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pla2g12b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycerophospholipid metabolism	GPD1C;PLA2G12A;PLA2G16;LPCAT3;PLA2G4F;DGKAA;GNPAT;PLA2G2E;EPT1
Ether lipid metabolism	UGT8;PLA2G12A;LPCAT4;TMEM86B;PLA2G2F;CEPT1;PLA2G1B;PPAP2CB;PLA2G4AA
Arachidonic acid metabolism	CYP4F18;ALOX12E;FAAH2B;PLA2G10;PLA2G4F;TBXAS1;PTGR1;PLA2G2D;PLA2G12A
Linoleic acid metabolism	CYP2P9;PLA2G5;CYP2C19;CYP2C39;CYP2P10;CYP2P8;PLA2G1B;CYP2J5;PLA2G10
alpha-Linolenic acid metabolism	PLA2G2D;ACAA1;PLA2G2A;ACOX3;ACAA1A;PLA2G2E;PLA2G4C;PLA2G3;PLA2G12B
Metabolic pathways	NT5C1B;NDUFB9;ATP5D;MAN1A2;MINPP1;GBA3;AANAT1;POLR2J;AMPD1
Ras signaling pathway	GNG11;ARF6;FLT4;FGF8;FGF10;PLA1A;RASA3;VEGFB;MAPK8
Vascular smooth muscle contraction	CALD1;PRKCQ;PLA2G12A;ITPR1;PRKCG;ARHGEF12;GNA13A;PLCB4;CALM4
Pancreatic secretion	SLC4A4;PLA2G2F;ATP1B1;CLCA4;RAP1A;ATP1A1;ATP2B1;ATP1B2;TPCN2
Fat digestion and absorption	GOT2;PLA2G2A;PLA2G2D;PPAP2A;PNLIPRP1;PLA2G5;DGAT2;SLC27A4;PLA2G1B

Pla2g12b has several biochemical functions, for example, calcium ion binding, metal ion binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by Pla2g12b itself. We selected most functions Pla2g12b had, and list some proteins which have the same functions with Pla2g12b. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	SPOCK1;LOC100686744;PROC;CDH20;EYS;EFHA2;MGMT;ACTN1;MMP25
metal ion binding	PRKD1;ZNF19;UNC13B;ZNF608;MCEE;PDE7A;THAP3;ACY3.1;NEK9
molecular_function	SCML4;DEFB20;ADAMTS16;VPS13A;DSCR4;CRYBA2B;GOLIM4;NLRP4B;CA10
phospholipase A2 activity	OC90;PLA2G2F;PLA2G2D;PLA2G4D;PLA2G12B;PRDX6;PLA2G16;RARRES3;PLA2G6

Pla2g12b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pla2g12b here. Most of them are supplied by our site. Hope this information will be useful for your research of Pla2g12b.