PLA2G2E
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Official Full Name
phospholipase A2, group IIE -
Overview
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids. -
Synonyms
PLA2G2E;phospholipase A2, group IIE;group IIE secretory phospholipase A2;2IIE;EC 3.1.1.4;GIIE sPLA2;Group IIE secretory phospholipase A2 precursor;Phosphatidylcholine 2 acylhydrolase GIIE;Phosphatidylcholine 2-acylhydrolase 2E;Phospholipase A2 group IIE;sPLA;sPLA2-IIE
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Pla2g2e -1196M | Recombinant Mouse Pla2g2e protein, His-tagged | HEK293 | Mouse | His | Met 1-Cys 142 |
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| Pla2g2e-1196M | Recombinant Mouse Pla2g2e, His-tagged | Human Cells | Mouse | His | 1-142 a.a. |
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| PLA2G2E-4101C | Recombinant Chicken PLA2G2E | Mammalian Cells | Chicken | His |
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| PLA2G2E-69H | Recombinant Human Phospholipase A2, Group IIE, His-tagged | E.coli | Human | His |
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| PLA2G2E-1874MCL | Recombinant Mouse PLA2G2E cell lysate | Human Cells | Mouse | Non |
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Involved Pathway
PLA2G2E involved in several pathways and played different roles in them. We selected most pathways PLA2G2E participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pancreatic secretion | RAB11A,BST1,Car2,PNLIP,CPB1,AMY2A4,RYR2,PLA2G1B,PLCB4,CELA2B |
| Ras signaling pathway | PRKCG,FGF22,HTR7,FGF17,GNG13,GNG3,SHC2,FGFR3,FGF1,PIK3CG |
| Ether lipid metabolism | PLA2G12A,PPAP2B,PLA2G4A,PAFAH1B2,PLD4,PPAP2C,GAL3ST1,PLA2G4D,PLD3,PLA2G10 |
| Glycerophospholipid metabolism | LPIN3,PISD,PLA2G15,PCYT1BA,CRLS1,PNPLA7,DGKB,PHYKPL,PLA2G12B,LCLAT1 |
| Vascular smooth muscle contraction | PPP1R12B,PRKCE,RAF1,PRKCD,PRKCH,RHOAD,CALD1B,PRKACG,ACTA2,NPR1A |
| Metabolic pathways | POLG,PANK4,NDUFC1,HSD17B2,PAPSS2A,UGT1A7,UGCG,DNMT3B,FUT2,CYP26B1 |
| Arachidonic acid metabolism | CYP2B6,AWAT1,GGT5,AWAT2,CYP2AD2,ALOX5,CYP2J6,CYP1A2,CYP4A11,CYP2C19 |
| alpha-Linolenic acid metabolism | PLA2G4F,PLA2G2A,PLA2G2D,PLA2G6,FADS2,PLA2G3,PLA2G4AA,ACAA1A,PLA2G1B,PLA2G4C |
| Linoleic acid metabolism | CYP3A65,PLA2G4D,CYP2C50,PLA2G5,CYP2J5,PLA2G2A,PLA2G4F,PLA2G4A,CYP2C39,CYP2C8 |
Protein Function
PLA2G2E has several biochemical functions, for example, calcium ion binding,phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2E itself. We selected most functions PLA2G2E had, and list some proteins which have the same functions with PLA2G2E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | DGKA,EFCAB1,PCDHGA8,SCUBE1,ANXA1C,LETM1,EFCAB4A,ACTN3A,PCDHGB6,SNCA |
| phospholipase A2 activity | OC90,PLA2G2D,LCAT,PLA2G4AA,PLA2G12B,ABHD3,PLA2G2A,PLA2G4A,PLA2G6,PLA2G16 |
Interacting Protein
PLA2G2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2E here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2E.
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References
- Yamaguchi, K; Chijiwa, T; et al. The Finding of a Group IIE Phospholipase A(2) Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A(2) Genes. TOXINS 6:3471-3487(2014).
- Karray, A; Ben Ali, Y; et al. Drastic changes in the tissue-specific expression of secreted phospholipases A2 in chicken pulmonary disease. BIOCHIMIE 94:451-460(2012).
