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Official Full Name phospholipase A2, group IIE
Background Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
Synonyms PLA2G2E; phospholipase A2, group IIE; group IIE secretory phospholipase A2; 2IIE; EC; GIIE sPLA2; Group IIE secretory phospholipase A2 precursor; Phosphatidylcholine 2 acylhydrolase GIIE; Phosphatidylcholine 2-acylhydrolase 2E; Phospholipase A2 group IIE; sPLA; sPLA2-IIE
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G2E-69H Recombinant Human Phospholipase A2, Group IIE, His-tagged E.coli His
    Mouse Pla2g2e -1196M Recombinant Mouse Pla2g2e protein, His-tagged HEK293 His
    Mouse Pla2g2e-1196M Recombinant Mouse Pla2g2e, His-tagged Human Cell His
    Mouse PLA2G2E-1874MCL Recombinant Mouse PLA2G2E cell lysate Human Cell N/A
    Chicken PLA2G2E-4101C Recombinant Chicken PLA2G2E Mammalian Cell His

    pla2g2e involved in several pathways and played different roles in them. We selected most pathways pla2g2e participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with pla2g2e were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism LPIN1; TAZ; PLD2; GPD1A; CHPT1; ETNPPL; PLD1A; LPIN2; PCYT1AA; MBOAT2
    Ether lipid metabolism PPAP2B; ENPP6; PLA2G4D; PLB1; PLA2G4A; GAL3ST1; PLD3; PAFAH1B3; ENPP2; LPCAT1
    Arachidonic acid metabolism LTA4H; CYP4A14; CYP2P7; CYP2C9; PLA2G2D; PLB1; ALOX5; CYP2C37; PTGR1; ALOX12E
    Linoleic acid metabolism CYP2P9; PLA2G6; CYP2P6; CYP3A65; CYP2P10; PLA2G12A; PLA2G4D; CYP3A41A; PLA2G2A; CYP3A25
    alpha-Linolenic acid metabolism ACAA1A; PLA2G2D; ACAA1; PLA2G4C; PLA2G12A; PLA2G2A; PLA2G4AA; PLA2G4F; PLA2G12B; ACOX3
    Metabolic pathways Ckmm; GALNT4; TBXAS1; ASAH1A; GALM; DPAGT1; PAPSS2B; MAOB; MTHFD2L; POLR2D
    Ras signaling pathway RAC1; PLA2G4A; FGF20; PIK3CB; FLT1; CALM1; FGFR4; PAK7; PRKCA; FGF13
    Vascular smooth muscle contraction PRKCQ; PPP1R14AB; GUCY1B3; PTGIR; CALM1A; ADCY2B; ROCK2; CALM3A; MYL9A; PRKACB
    Pancreatic secretion RAB11A; PLA2G2E; PLA2G5; ATP1A4; AMY2B; SLC26A3; ATP2A1; ITPR3; SCTR; CTRB1
    Fat digestion and absorption APOA1; MOGAT2; APOB; GOT2; PLA2G12B; ACAT2; PLA2G2F; SLC27A4; PLA2G2D; MTTP

    pla2g2e has several biochemical functions, for example, calcium ion binding, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by pla2g2e itself. We selected most functions pla2g2e had, and list some proteins which have the same functions with pla2g2e. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding FAT3A; SPOCK2; CALML5; PCDH15A; CETN3; JAG1A; MASP2; CAPN11; MMP1A; NCALDB
    phospholipase A2 activity PLA2G6; PLA2G12B; PLA2G10; PLA2G2E; PRDX6; PLA2G1B; LCAT; PLA2G2F; RARRES3; PLA2G4A

    pla2g2e has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pla2g2e here. Most of them are supplied by our site. Hope this information will be useful for your research of pla2g2e.

    Yamaguchi, K; Chijiwa, T; et al. The Finding of a Group IIE Phospholipase A(2) Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A(2) Genes. TOXINS 6:3471-3487(2014).
    Karray, A; Ben Ali, Y; et al. Drastic changes in the tissue-specific expression of secreted phospholipases A2 in chicken pulmonary disease. BIOCHIMIE 94:451-460(2012).

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