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PLA2G2E

Official Full Name

phospholipase A2, group IIE
Overview

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
Synonyms

PLA2G2E; phospholipase A2, group IIE; group IIE secretory phospholipase A2; 2IIE; EC 3.1.1.4; GIIE sPLA2; Group IIE secretory phospholipase A2 precursor; Phosphatidylcholine 2 acylhydrolase GIIE; Phosphatidylcholine 2-acylhydrolase 2E; Phospholipase A2 group IIE; sPLA; sPLA2-IIE;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLA2G2E-69H	Recombinant Human Phospholipase A2, Group IIE, His-tagged	E.coli	His		Inquiry
Mouse	Pla2g2e -1196M	Recombinant Mouse Pla2g2e protein, His-tagged	HEK293	His	Met 1-Cys 142	Inquiry
Mouse	Pla2g2e-1196M	Recombinant Mouse Pla2g2e, His-tagged	Human Cell	His		Inquiry
Mouse	PLA2G2E-1874MCL	Recombinant Mouse PLA2G2E cell lysate	Human Cell	N/A		Inquiry
Chicken	PLA2G2E-4101C	Recombinant Chicken PLA2G2E	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PLA2G2E involved in several pathways and played different roles in them. We selected most pathways PLA2G2E participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycerophospholipid metabolism	PISD;GPD1A;AGPAT9L;CDS2;PLA2G12A;PLA2G2A;CHKA;PLA2G5;PPAP2CB
Ether lipid metabolism	LPCAT1;PLA2G1B;PLD1A;PLA2G4D;CHPT1;PLA2G2D;PLA2G4B;PPAP2CB;TMEM86B
Arachidonic acid metabolism	DPEP1;FAAH2A;PLA2G4F;CYP4A10;CYP2AD3;CYP2C70;CYP4A12A;ALOX5AP;CYP1A1
Linoleic acid metabolism	PLA2G4F;CYP2C55;CYP2C45;PLA2G4AA;PLA2G2D;PLA2G6;CYP3A65;ALOX15;PLA2G12B
alpha-Linolenic acid metabolism	ACOX3;PLA2G2E;PLA2G5;ACOX1;ACAA1A;PLA2G4F;PLA2G12B;PLA2G4AA;PLA2G1B
Metabolic pathways	GK;HSD3B6;ANPEP;ALDOB;B3GNT5A;PPT2;HSD17B4;GNE;GCSH
Ras signaling pathway	PIK3R2;RRAS2;NFKB1;FGF19;AKT1;PIK3R1;KLK1B4;FLT1;MLLT4
Vascular smooth muscle contraction	GNA11A;CYP4A12A;ACTG2;PLA2G4D;CACNA1DA;PLA2G4F;CACNA1C;MAP2K1;PLA2G4A
Pancreatic secretion	PLA2G12A;PRSS2;RHOA;PRKCG;Car2;CLCA5;CD38;ATP1A2;PLA2G5
Fat digestion and absorption	LIPF;PNLIP;CLPS;CD36;APOA4;ACAT2;GOT2;PLA2G3;PLA2G12A

PLA2G2E has several biochemical functions, for example, calcium ion binding, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2E itself. We selected most functions PLA2G2E had, and list some proteins which have the same functions with PLA2G2E. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PCDHB7;THBS3;CABP2;PCDH8;RHBDL3;PROC;CELSR3;FBLN7;PCDH1G32
phospholipase A2 activity	PLB1;LCAT;PLA2G6;PLA2G2E;PLA2G4AA;PLA2G2A;PLA2G4D;ABHD3;OC90

PLA2G2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2E here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2E.

Research Area

Yamaguchi, K; Chijiwa, T; et al. The Finding of a Group IIE Phospholipase A(2) Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A(2) Genes. TOXINS 6:3471-3487(2014).

Karray, A; Ben Ali, Y; et al. Drastic changes in the tissue-specific expression of secreted phospholipases A2 in chicken pulmonary disease. BIOCHIMIE 94:451-460(2012).