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Official Full Name phospholipase A2, group VI (cytosolic, calcium-independent)
Background The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.
Synonyms PLA2G6; phospholipase A2, group VI (cytosolic, calcium-independent); 85 kDa calcium-independent phospholipase A2; iPLA2; PARK14; PNPLA9; 85 kDa calcium independent phospholipase A2; CaI PLA2; CaI-PLA2; CaIPLA2; Calcium independent phospholipase A2; Cytosolic calcium independent phospholipase A2; EC; Group VI phospholipase A2; GVI; GVI PLA2; INAD1; iPLA(2)beta; IPLA2 VIA; iPLA2beta; NBIA2A; NBIA2B; PA2G6_HUMAN; Patatin like phospholipase domain containing 9; Patatin like phospholipase domain containing protein 9; Phospholipase A2 calcium independent; Phospholipase A2 calcium independent group VI A; Phospholipase A2 group VI; Phospholipase A2 group VI cytosolic calcium independent; PLA2; calcium-independent phospholipase A2; patatin-like phospholipase domain containing 9; cytosolic, calcium-independent phospholipase A2; IPLA2-VIA
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G6-1756H Recombinant Human PLA2G6, His-tagged E.coli His
    Human PLA2G6-185H Recombinant Human PLA2G6 protein, GST-tagged Wheat Germ GST
    Human PLA2G6-186H Recombinant Human PLA2G6 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLA2G6-187H Recombinant Human PLA2G6 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLA2G6-2752H Recombinant Human PLA2G6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PLA2G6-3139HCL Recombinant Human PLA2G6 293 Cell Lysate HEK293 N/A
    Human PLA2G6-383H Recombinant Human PLA2G6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human PLA2G6-611H Recombinant Human PLA2G6 Protein, His-tagged E.coli His
    Mouse PLA2G6-12901M Recombinant Mouse PLA2G6 Protein Mammalian Cell His
    Mouse Pla2g6-4903M Recombinant Mouse Pla2g6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Pla2g6-612M Recombinant Mouse Pla2g6 Protein, His-tagged E.coli His
    Rat Pla2g6-613R Recombinant Rat Pla2g6 Protein, His-tagged E.coli His
    Chicken PLA2G6-3856C Recombinant Chicken PLA2G6 Mammalian Cell His
    Zebrafish PLA2G6-12322Z Recombinant Zebrafish PLA2G6 Mammalian Cell His

    PLA2G6 involved in several pathways and played different roles in them. We selected most pathways PLA2G6 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism LPIN1; DGKA; AGXT2L1; LYCAT; PLD3; GPD1B; DGKQ; PLD4; CHATA; PLA2G10
    Ether lipid metabolism LPCAT1; PLA2G16; PLD2; PPAP2B; CEPT1B; PLA2G5; PAFAH1B1A; AGPS; GAL3ST1A; PLA2G4AA
    Arachidonic acid metabolism CYP4A11; CYP4F14; PTGDSB; CYP2E1; PLA2G6; CYP2J6; AKR1C21; AWAT2; PLA2G1B; CYP2P7
    Linoleic acid metabolism PLA2G10; CYP3A25; PLA2G6; CYP2C55; CYP2C54; CYP2C50; PLA2G4C; CYP3A65; PLA2G4D; CYP2C37
    alpha-Linolenic acid metabolism PLA2G3; ACAA1; FADS2; ACOX1; PLA2G2A; PLA2G4AA; PLA2G1B; PLA2G4F; ACOX3; PLA2G12B
    Metabolic pathways PRPS1; GALNT9; SPR; NDUFS5; AOC2; INPP5A; HSD11B1; COMTA; LIPT2; B3GNT5B
    Ras signaling pathway KSR1; PIK3CG; GNG13; PRKCA; PDGFB; NGFR; GNG2; BCL2L1; GNG8; RAB5B
    Vascular smooth muscle contraction CYP4A14; GNA13A; CALM3; PLA2G2E; ARHGEF12; GUCY1A3; CALM2B; ROCK2A; PRKCH; EDNRAA
    Fc gamma R-mediated phagocytosis VAV1; HCK; AMPH; FCGR1A; PIK3CA; PAK1; WAS; ARPC5L; MAP2K1; WASF1
    Inflammatory mediator regulation of TRP channels CYP2C50; PLA2G4F; PRKCD; ASIC1; NTRK1; TRPV4; PIK3R3; CALM4; IGF1; CYP2J6

    PLA2G6 has several biochemical functions, for example, calmodulin binding, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G6 itself. We selected most functions PLA2G6 had, and list some proteins which have the same functions with PLA2G6. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding CAMSAP1; KCNQ3; MARCKSL1B; MYH3; IQGAP3; NDUFAF4; SPATA17; ADD1; PPP3CC; NRGNA
    phospholipase A2 activity PLA2G10; LCAT; PLA2G2D; PLB1; PLA2G2A; PLA2G4D; PLA2G4AA; PLA2G12B; PLA2G6; ABHD3

    PLA2G6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G6.

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