PLA2G6
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Official Full Name
phospholipase A2, group VI (cytosolic, calcium-independent)
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Overview
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. -
Synonyms
PLA2G6; phospholipase A2, group VI (cytosolic, calcium-independent); 85 kDa calcium-independent phospholipase A2; iPLA2; PARK14; PNPLA9; 85 kDa calcium independent phospholipase A2; CaI PLA2; CaI-PLA2; CaIPLA2; Calcium independent phospholipase A2; Cytosolic calcium independent phospholipase A2; EC 3.1.1.4; Group VI phospholipase A2; GVI; GVI PLA2; INAD1; iPLA(2)beta; IPLA2 VIA; iPLA2beta; NBIA2A; NBIA2B; PA2G6_HUMAN; Patatin like phospholipase domain containing 9; Patatin like phospholipase domain containing protein 9; Phospholipase A2 calcium independent; Phospholipase A2 calcium independent group VI A; Phospholipase A2 group VI; Phospholipase A2 group VI cytosolic calcium independent; PLA2; calcium-independent phospholipase A2; patatin-like phospholipase domain containing 9; cytosolic, calcium-independent phospholipase A2; IPLA2-VIA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PLA2G6 involved in several pathways and played different roles in them. We selected most pathways PLA2G6 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | PCYT1AA;PLA2G3;PCYT2;PPAP2D;PLD1A;LPIN1;PPAP2CB;GPD1L;MBOAT2B |
| Ether lipid metabolism | AGPS;PPAP2B;CHPT1;UGT8;PLA2G6;PLD2;PLA2G4C;PPAP2D;PLA2G2F |
| Arachidonic acid metabolism | ALOX12E;CYP2P10;PLA2G4AA;ALOX5;PTGS1;PTGESL;CYP2C70;PTGES3B;CYP2Y3 |
| Linoleic acid metabolism | PLA2G2F;PLA2G12A;CYP3A41B;CYP2C70;PLA2G4AA;CYP2C19;CYP2C45;CYP2J6;PLA2G12B |
| alpha-Linolenic acid metabolism | PLA2G1B;PLA2G2D;PLA2G12A;ACOX3;PLA2G2F;PLA2G5;PLA2G4D;PLA2G4AA;FADS2 |
| Metabolic pathways | NDUFAB1;PIGL;EXT1C;PRODH2;Acsm2a;CMPK1;ATP5O;IMPA1;IMPDH1 |
| Ras signaling pathway | FGF8;GNG11;FGFR4;PIK3CD;GNB4;AKT2;ETS2;KIT;KITLG |
| Vascular smooth muscle contraction | KCNMB2;PRKG1;PRKCHA;ADCY1A;PPP1R14A;PLA2G2E;PPP1CB;PLA2G3;PLCB1 |
| Fc gamma R-mediated phagocytosis | MYO10;CDC42;PLA2G4D;SYK;PIK3R1;VASP;PRKCD;PIK3R2;PIP5K1A |
| Inflammatory mediator regulation of TRP channels | IL1RAP;ASIC1;TRPM8;NTRK1;ASIC2;PRKACG;IL1B;SRC;PRKCD |
PLA2G6 has several biochemical functions, for example, calmodulin binding, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G6 itself. We selected most functions PLA2G6 had, and list some proteins which have the same functions with PLA2G6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | ADCY1;TRPV6;GAP43;TRPV1;MYO9B;RASGRF2B;TTN;MAPKAPK2A;MYO7A |
| phospholipase A2 activity | PLB1;PRDX6;PLA2G6;PNPLA3;PLA2G2F;PLA2G4A;PLA2G4D;PLA2G12B;OC90 |
PLA2G6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G6.
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