Active Recombinant Human TNFSF13, FLAG-tagged
Cat.No. : | TNFSF13-399H |
Product Overview : | The extracellular domain of human APRIL (aa 98-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG-tag. |
- Specification
- Gene Information
- Related Products
Description : | APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MegaAPRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells. |
Source : | HEK293 Cells |
Species : | Human |
Tag : | FLAG |
Form : | Lyophilized. Contains PBS + 0.5% Trehalose. |
Bio-activity : | Stimulates B cell proliferation. |
Molecular Mass : | ~34kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 0.1mg/ml after reconstitution. |
Gene Name : | TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 [ Homo sapiens ] |
Official Symbol : | TNFSF13 |
Synonyms : | TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; APRIL; CD256; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF- and APOL-related leukocyte expressed ligand 2; TALL2; ZTNF2; TALL-2; TRDL-1; FLJ57090; UNQ383/PRO715; |
Gene ID : | 8741 |
mRNA Refseq : | NM_001198622 |
Protein Refseq : | NP_001185551 |
MIM : | 604472 |
UniProt ID : | O75888 |
Chromosome Location : | 17p13.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Gene Expression, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; |
Function : | cytokine activity; receptor binding; tumor necrosis factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
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Tnfsf13-440T | Active Recombinant Mouse Tnfsf13 Protein (192 aa) | +Inquiry |
TNFSF13-318H | Recombinant Active Human TNFSF13 Protein, His-tagged(C-ter) | +Inquiry |
Tnfsf13-155M | Active Recombinant Mouse Tnfsf13 Protein | +Inquiry |
TNFSF13-13R | Recombinant Rabbit TNFSF13 Protein | +Inquiry |
◆ Lysates | ||
TNFSF13-1346MCL | Recombinant Mouse TNFSF13 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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