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Official Full Name tumor necrosis factor (ligand) superfamily, member 12
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Synonyms TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; APO3L; DR3LG; TWEAK
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mouse
    • Tag :
    • Fc
    • His
    • Flag
    • GST
    • Met
    • N/A
    • RlgG Fc
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DMABT-H18373 Mouse Anti-TNFSF12 Monoclonal Antibody Mouse N/A
    Human TNFSF12-1068H Recombinant Human TNFSF12 protein, His-tagged E.coli His
    Human TNFSF12-2097H Recombinant Human TNFSF12, FLAG-tagged E.coli Flag
    Human TNFSF12-565H Recombinant Human TNFSF12 E.coli N/A
    Human TNFSF12-70H Recombinant Human TWEAK, FLAG-tagged E.coli Flag
    Human TNFSF12-8461H Recombinant Human TNFSF12 E.coli N/A
    Mouse Tnfsf12-1069M Recombinant Mouse Tnfsf12 protein, His-tagged E.coli His
    Mouse TNFSF12-17173M Recombinant Mouse TNFSF12 Protein Mammalian Cell His
    Mouse Tnfsf12-196M Recombinant Mouse Tnfsf12, FLAG-tagged HEK293 Flag
    Mouse TNFSF12-810M Recombinant Mouse TNFSF12 Protein (Arg105-His249), RlgG Fc-tagged HEK293 RlgG Fc
    Mouse Tnfsf12-852M Recombinant Mouse Tnfsf12 Protein, Fc-tagged HEK293 Fc
    Mouse Tnfsf12-983M Recombinant Mouse Tnfsf12 Protein, Met & His-tagged E.coli Met/His
    Rat TNFSF12-1204RCL Recombinant Rat TNFSF12 cell lysate Human Cell N/A
    Rat Tnfsf12-8728R Recombinant Rat Tnfsf12, Fc tagged Human Cell GST
    Cynomolgus Monkey TNFSF12-1155CCL Recombinant Cynomolgus TNFSF12 cell lysate Human Cell N/A
    Cynomolgus Monkey TNFSF12-8822C Recombinant Cynomolgus TNFSF12, Fc tagged Human Cell Fc/His
    Rhesus Macaque TNFSF12-4872R Recombinant Rhesus monkey TNFSF12 Protein, His-tagged Mammalian Cell His
    Zebrafish TNFSF12-4501Z Recombinant Zebrafish TNFSF12 Mammalian Cell His

    tnfsf12 involved in several pathways and played different roles in them. We selected most pathways tnfsf12 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfsf12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFSF11; TGFBR1; PDGFA; IL20RA; IL6R; Cxcl15; CNTF; IL22; CXCL9; IFN-a

    tnfsf12 has several biochemical functions, for example, cytokine activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfsf12 itself. We selected most functions tnfsf12 had, and list some proteins which have the same functions with tnfsf12. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity LFT1; GREM2; Il1f8; Fasl; IFNA4; GDF2; IFNL3; GDF10B; IL16; IL11
    protein binding SCARB2; PHF7; KAZN; FXN; PRDM4; UBXN8; SOX13; ZNF460; PIKFYVE; AICDA
    receptor binding ADAM10; Ren1; RAB8B; PARK7; GDNF; NXPH1; PVRL1A; SLC27A2; PIPOX; DHRS4
    tumor necrosis factor receptor binding FADD; TNFSF15; TRADD; TNFSF8; FASLG; TRAF6; TRAP1; TNF; TNFSF12; CASP8

    tnfsf12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfsf12 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfsf12.

    Sastre, C; Fernandez-Laso, V; et al. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:721-734(2014).
    Zhou, H; Hittelman, WN; et al. Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors. CANCER RESEARCH 73:4439-4450(2013).


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