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Official Full Name tumor necrosis factor (ligand) superfamily, member 8
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms TNFSF8; tumor necrosis factor (ligand) superfamily, member 8; CD30LG; tumor necrosis factor ligand superfamily member 8; CD153; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand; CD30L; MGC138144
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • NSO
    • Tag :
    • C-Myc/DDK
    • Fc
    • Flag
    • GST
    • His
    • Mouse
    • IgG2a
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFSF8-182H Recombinant Human TNFSF8 Protein, His-tagged Human Cells His
    Human TNFSF8-015H Recombinant Human TNFSF8 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human TNFSF8-156H Recombinant Human TNFSF8, His-tagged E.coli His
    Human TNFSF8-1595H Recombinant Human TNFSF8 NSO N/A
    Human TNFSF8-2076H Recombinant Human TNFSF8, FLAG-tagged HEK293 Flag
    Human TNFSF8-2258H Recombinant Human TNFSF8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TNFSF8-248H Recombinant Human TNFSF8, StrepII-tagged Human Cell Strep II
    Human TNFSF8-3051HCL Recombinant Human TNFSF8 cell lysate Human Cell N/A
    Human TNFSF8-326H Recombinant Human TNFSF8 Protein (Gln63-Asp234), Gly & Pro HEK293 N/A
    Human TNFSF8-3322H Recombinant Human TNFSF8, GST-tagged E.coli GST
    Human TNFSF8-333H Recombinant Human TNFSF8 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human TNFSF8-569H Recombinant Human TNFSF8, His-tagged, Biotinylated Human Cell His
    Human TNFSF8-570H Recombinant Human TNFSF8, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFSF8-60H Recombinant Human TNFSF8, Fc tagged Human Cell Fc
    Human TNFSF8-63H Recombinant Human TNFSF8 protein, His-tagged Insect Cell His
    Human TNFSF8-829H Recombinant Human TNFSF8 protein, His-tagged, low endotoxin HEK293 His
    Human TNFSF8-890H Recombinant Human TNFSF8 Protein, His-tagged CHO His
    Mouse Tnfsf8-1714M Recombinant Mouse Tnfsf8 NSO N/A
    Mouse TNFSF8-17180M Recombinant Mouse TNFSF8 Protein Mammalian Cell His
    Mouse Tnfsf8-6558M Recombinant Mouse Tnfsf8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tnfsf8-780M Recombinant Mouse Tnfsf8 protein, His-tagged E.coli His
    Rat TNFSF8-1053RCL Recombinant Rat TNFSF8 cell lysate Human Cell N/A
    Rat TNFSF8-381R Recombinant Rat Tnfsf8, Gly & Pro tagged Human Cell Fc
    Rat Tnfsf8-781R Recombinant Rat Tnfsf8 protein, His & GST-tagged E.coli His/GST
    Rat Tnfsf8-8723R Recombinant Rat Tnfsf8, Fc tagged Human Cell Fc
    Cynomolgus Monkey TNFSF8-1190CCL Recombinant Cynomolgus TNFSF8 cell lysate Human Cell N/A
    Cynomolgus Monkey TNFSF8-68C Recombinant Cynomolgus TNFSF8, His tagged Human Cell His
    Cynomolgus Monkey TNFSF8-8821C Recombinant Cynomolgus TNFSF8, Fc tagged Human Cell Fc
    Rhesus Macaque TNFSF8-4876R Recombinant Rhesus monkey TNFSF8 Protein, His-tagged Mammalian Cell His
    Chicken TNFSF8-5979C Recombinant Chicken TNFSF8 Mammalian Cell His

    tnfsf8 involved in several pathways and played different roles in them. We selected most pathways tnfsf8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfsf8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL4R; CCL4L2; IL4; INHBE; TNFRSF13B; CCR3; IL18RAP; ACVR1; CCL20; CCL3

    tnfsf8 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfsf8 itself. We selected most functions tnfsf8 had, and list some proteins which have the same functions with tnfsf8. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CMTM3; IFNA3; FAM3B; GPR19; IL1A; IL36A; CMTM2; SPP1; FASLG; IL17A/F1
    receptor binding CD160; HNF4A; FLT3LG; AGXT; HIST2H3C2; MATK; Artn; MLYCD; F2R; HCST
    tumor necrosis factor receptor binding TNFSF4; TNFSF14; LTB; TNFSF12; TRAF4; TNFSF8; TNFSF10L3; ERAP1; TNF; TNFSF13B

    tnfsf8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfsf8 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfsf8.

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