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Official Full Name tumor necrosis factor (ligand) superfamily, member 14
Background The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Synonyms TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; CD258; HVEM L; LIGHT; LTg; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TR2; HVEML
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cells
    • Insect cell
    • Mammalian Cell
    • NS0
    • Tag :
    • C-Myc/DDK
    • Flag
    • His
    • S
    • His-Flag
    • human
    • IgG1
    • Fc
    • Mouse
    • IgG2a
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFSF14-151H Recombinant Human TNFSF14 Protein, His-tagged Human Cells His
    Human TNFSF14-144H Recombinant Human TNFSF14 protein, His-Flag-tagged HEK293 His-Flag
    Human TNFSF14-207H Recombinant Human TNFSF14 protein, His-tagged HEK293 His
    Human TNFSF14-217H Recombinant Human TNFSF14 protein, His-tagged HEK293 His
    Human TNFSF14-288H Recombinant Human TNFSF14 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human TNFSF14-29946TH Recombinant Human TNFSF14, FLAG-tagged CHO Flag
    Human TNFSF14-29950TH Recombinant Human TNFSF14 N/A
    Human TNFSF14-354H Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 14 Human N/A
    Human TNFSF14-392H Recombinant Human TNFSF14, FLAG-tagged CHO Flag
    Human TNFSF14-394H Recombinant Human TNFSF14 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human TNFSF14-552H Recombinant Human TNFSF14 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human TNFSF14-7782H Recombinant Human TNFSF14 protein, His & S-tagged E.coli His/S
    Human TNFSF14-891HCL Recombinant Human TNFSF14 293 Cell Lysate HEK293 N/A
    Human TNFSF14-970H Recombinant Human TNFSF14 NS0 N/A
    Mouse Tnfsf14-147M Recombinant Mouse Tnfsf14 Protein E.coli
    Mouse TNFSF14-1544M Recombinant Mouse TNFSF14 Protein, His-tagged Insect cell His
    Mouse TNFSF14-17176M Recombinant Mouse TNFSF14 Protein Mammalian Cell His
    Mouse TNFSF14-2020M Recombinant Mouse TNFSF14 protein E.coli N/A
    Mouse Tnfsf14-6555M Recombinant Mouse Tnfsf14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tnfsf14-7783M Recombinant Mouse Tnfsf14 protein, His & S-tagged E.coli His/S
    Mouse Tnfsf14-948M Recombinant Mouse Tnfsf14 E.coli N/A
    Rat Tnfsf14-7784R Recombinant Rat Tnfsf14 protein, His-tagged E.coli His
    Cynomolgus Monkey TNFSF14-1040C Recombinant Cynomolgus TNFSF14 Protein, His-tagged Mammalian Cell His
    Rhesus monkey TNFSF14-1636R Recombinant Rhesus Monkey TNFSF14 Protein HEK293 N/A

    tnfsf14 involved in several pathways and played different roles in them. We selected most pathways tnfsf14 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfsf14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFSF13B; IL3RA; BMPR1AB; CX3CL1; CCL14; IL23; GM13304; TGFB2; LEPR; CCL4L1
    NF-kappa B signaling pathway PTGS2; TNF; IL-8; BLNK; VCAM1; TNFRSF1A; BCL2L1; MYD88; CD14; TRAF6
    Herpes simplex infection HLA-DRB5; HCFC2; HCFC1; SRSF1; BLB1; SFRS3B; SRSF2; HNRPK; RNASEL; PTPN11B

    tnfsf14 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfsf14 itself. We selected most functions tnfsf14 had, and list some proteins which have the same functions with tnfsf14. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process SNCA; LEF1; NAIP1; AVP; MT3; TNFSF14; ARRB1; IGF1RB; C1QL4L; TFAP2B
    cytokine activity WNT5A; IFNA5; WNT2; BMP2B; IL7; Gm13290; IL36RN; IFNE; NRG1; CCL6
    protein binding TDP2; FMNL3; SEC22B; TCERG1; AHCYL2; RAI2; BAZ1A; ELP4; NABP1; LGR4
    receptor binding DRD1A; LTA; HLA-B; BMP3; ARPP19A; CXCL1; P2RX4; KNG1; TNFSF12; TNFSF4
    tumor necrosis factor receptor binding CD70; TNFSF4; TRIM37; ERAP1; TRAF4; Fasl; TRADD; TNFSF10L4; TRAF3; TRAF1

    tnfsf14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfsf14 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfsf14.


    del Rio, ML; Fernandez-Renedo, C; et al. Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin beta Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. TRANSPLANTATION 98:1165-1174(2014).
    Kojima, R; Kajikawa, M; et al. Molecular Basis for Herpesvirus Entry Mediator Recognition by the Human Immune Inhibitory Receptor CD160 and Its Relationship to the Cosignaling Molecules BTLA and LIGHT. JOURNAL OF MOLECULAR BIOLOGY 413:762-772(2011).


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