|Official Full Name||tumor necrosis factor (ligand) superfamily, member 14|
|Background||The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.|
|Synonyms||TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; CD258; HVEM L; LIGHT; LTg; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TR2; HVEML|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
tnfsf14 involved in several pathways and played different roles in them. We selected most pathways tnfsf14 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfsf14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||TNFSF13B; IL3RA; BMPR1AB; CX3CL1; CCL14; IL23; GM13304; TGFB2; LEPR; CCL4L1|
|NF-kappa B signaling pathway||PTGS2; TNF; IL-8; BLNK; VCAM1; TNFRSF1A; BCL2L1; MYD88; CD14; TRAF6|
|Herpes simplex infection||HLA-DRB5; HCFC2; HCFC1; SRSF1; BLB1; SFRS3B; SRSF2; HNRPK; RNASEL; PTPN11B|
tnfsf14 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfsf14 itself. We selected most functions tnfsf14 had, and list some proteins which have the same functions with tnfsf14. You can find most of the proteins on our site.
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process||SNCA; LEF1; NAIP1; AVP; MT3; TNFSF14; ARRB1; IGF1RB; C1QL4L; TFAP2B|
|cytokine activity||WNT5A; IFNA5; WNT2; BMP2B; IL7; Gm13290; IL36RN; IFNE; NRG1; CCL6|
|protein binding||TDP2; FMNL3; SEC22B; TCERG1; AHCYL2; RAI2; BAZ1A; ELP4; NABP1; LGR4|
|receptor binding||DRD1A; LTA; HLA-B; BMP3; ARPP19A; CXCL1; P2RX4; KNG1; TNFSF12; TNFSF4|
|tumor necrosis factor receptor binding||CD70; TNFSF4; TRIM37; ERAP1; TRAF4; Fasl; TRADD; TNFSF10L4; TRAF3; TRAF1|
tnfsf14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfsf14 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfsf14.
TNFRSF14; TNFRSF6B; LTB