tumor necrosis factor (ligand) superfamily, member 13b
Overview
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Synonyms
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor superfamily, member 13b; tumor necrosis factor superfamily, member 13b; TNFSF13B; CD257 antigen;
TNFSF13B involved in several pathways and played different roles in them. We selected most pathways TNFSF13B participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFRSF13C;TNFSF13B
TNFSF13B has several biochemical functions, for example, cytokine activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF13B itself. We selected most functions TNFSF13B had, and list some proteins which have the same functions with TNFSF13B. You can find most of the proteins on our site.
TNFSF13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF13B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF13B.
Nocturne, G; Mariette, X; et al. Sjogren Syndrome-associated lymphomas: an update on pathogenesis and management. BRITISH JOURNAL OF HAEMATOLOGY 168:317-327(2015).
Pellkofer, HL; Krumbholz, M; et al. Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. NEUROLOGY 76:1310-1315(2011).
