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Official Full Name tumor necrosis factor (ligand) superfamily, member 13
Background The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Synonyms TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; APRIL; CD256; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF-
    • Species :
    • Cattle
    • Cynomolgus
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Hi-5 Insect Cell
    • Human
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • NS0
    • Yeast
    • Tag :
    • Fc
    • Flag
    • GST
    • His
    • HA
    • S
    • T7
    • His-Avi-Flag
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus TNFSF13-754C Recombinant Cynomolgus TNFSF13 protein, His-Avi-Flag-tagged HEK293 His-Avi-Flag
    Human TNFSF13-141H Recombinant Human TNFSF13 Protein, His-tagged Human Cells His
    Human TNFSF13-142H Recombinant Human TNFSF13 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human APRIL-3591H Recombinant Human APRIL Hi-5 Insect Cell N/A
    Human TNFSF13-1045H Recombinant Human TNFSF13 protein, HA-tagged HEK293 HA
    Human TNFSF13-2091H Recombinant Human TNFSF13, FLAG-tagged HEK293 Flag
    Human TNFSF13-2141H Recombinant Human TNFSF13, Fc Chimera Mammalian Cell Fc
    Human TNFSF13-26H Recombinant Human TNFSF13 Protein, His-FLAG-tagged HEK293 His/Flag
    Human TNFSF13-348H Recombinant Human TNFSF13 NS0 N/A
    Human TNFSF13-349H Recombinant Human TNFSF13, HA-tagged HEK293 HA
    Human TNFSF13-350H Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Human N/A
    Human TNFSF13-351H Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Human N/A
    Human TNFSF13-386H Recombinant Human TNFSF13 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human TNFSF13-399H Recombinant Human TNFSF13, FLAG-tagged HEK293 Flag
    Human TNFSF13-505H Recombinant Human tumor necrosis factor (ligand) superfamily, member 13, T7 tagged E.coli T7
    Human TNFSF13-5106H Recombinant Human TNFSF13, T7-tagged E.coli T7
    Human TNFSF13-655H Recombinant Human TNFSF13 protein, His-tagged HEK293 His
    Human TNFSF13-875H Recombinant Human TNFSF13 Protein, GST-His-tagged E.coli GST/His
    Mouse TNFSF13-1346MCL Recombinant Mouse TNFSF13 cell lysate Human Cell N/A
    Mouse Tnfsf13-155M Recombinant Mouse Tnfsf13 Protein E.coli
    Mouse Tnfsf13-1744M Recombinant Mouse Tnfsf13 protein, His-tagged E.coli His
    Mouse TNFSF13-2028M Recombinant Mouse TNFSF13 Protein E.coli N/A
    Mouse Tnfsf13-696M Recombinant Mouse Tnfsf13 CHO N/A
    Mouse Tnfsf13-8691M Recombinant Mouse Tnfsf13, Fc-tagged Human Cell Fc
    Mouse Tnfsf13-930M Recombinant Murine Tnfsf13 E.coli N/A
    Mouse Tnfsf13-931M Recombinant Mouse Tnfsf13, Fc tagged Human Cell Fc
    Mouse Tnfsf13-933M Recombinant Mouse Tnfsf13 protein E.coli N/A
    Mouse Tnfsf13-936M Recombinant Mouse Tnfsf13, Flag-tagged HEK293 Flag
    Rat Tnfsf13-16R Recombinant Rat Tnfsf13 Protein Yeast
    Rat Tnfsf13-17R Recombinant Rat Tnfsf13 protein, His-tagged E.coli His
    Cynomolgus TNFSF13-754CB Recombinant Cynomolgus TNFSF13 protein, His-Avi-Flag-tagged, Biotinylated HEK293 His-Avi-Flag
    Rhesus monkey TNFSF13-1635R Recombinant Rhesus Monkey TNFSF13 Protein HEK293 N/A
    Rhesus monkey TNFSF13-25R Recombinant Rhesus monkey TNFSF13 protein, His-tagged E.coli His
    Rhesus Macaque TNFSF13-4873R Recombinant Rhesus monkey TNFSF13 Protein, His-tagged Mammalian Cell His
    Dog TNFSF13-1743D Recombinant Dog TNFSF13 protein, His & S-tagged E.coli His/S
    Zebrafish TNFSF13-7646Z Recombinant Zebrafish TNFSF13 Mammalian Cell His
    Cattle TNFSF13-1742C Recombinant Cattle TNFSF13 protein, His & T7-tagged E.coli His/T7

    tnfsf13 involved in several pathways and played different roles in them. We selected most pathways tnfsf13 participated on our site, such as Cytokine-cytokine receptor interaction, Intestinal i, ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfsf13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL15; CXCL8; CD27; BMPR1BA; IFNB; PDGFAA; FLT3LG; CCL19; GM13305; KIT
    Intestinal i CCR10; CD80; HLA-DRB4; HLA-DMB; IL4; CCL28; CXCR4A; ITGB7; CCL25; BMA1
    ne network for IgA production IL4; IL15; CXCR4B; CCL28; BMA2; BLA; HLA-DMB; H2-AB1; ICOS; CCL25B
    Rheumatoid arthritis ATP6V1C1; MMP1A; CXCL6; HLA-DMA; TNF; ATP6V1F; ATP6V0A4; IL23; CCL2; HLA-DQA1

    tnfsf13 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfsf13 itself. We selected most functions tnfsf13 had, and list some proteins which have the same functions with tnfsf13. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity RNF207B; TGFB1A; IL15L; GM13288; IFNA4; MSTNA; IL8L2; TNFSF13; CCL38A.5; GPR19
    receptor binding PLA2G1B; IL29; AMACR; SNX17; NPFF; AGXT; PVRL2L; CSK; PVRL1; PVRL3B
    tumor necrosis factor receptor binding TRAF1; TNFSF12; TRIM37; TNFSF10L; TNFSF10L3; TNFSF10; TNFB; TRAP1; TRAF3; CASP8

    tnfsf13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfsf13 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfsf13.


    Osorio, C; Chacon, PJ; et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. MOLECULAR AND CELLULAR NEUROSCIENCE 59:24-36(2014).
    Kutukculer, N; Gulez, N; et al. Three Different Classifications, B Lymphocyte Subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) Gene Mutations, CTLA-4 and ICOS Gene Polymorphisms in Turkish Patients with Common Variable Immunodeficiency. JOURNAL OF CLINICAL IMMUNOLOGY 32:1165-1179(2012).


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