TNFSF13

  • Official Full Name

    tumor necrosis factor (ligand) superfamily, member 13

  • Overview

    The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
  • Synonyms

    TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; APRIL; CD256; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF-;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Cattle
  • Cynomolgus
  • Dog
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Hi-5 Insect Cell
  • Human
  • Human Cell
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • DYKDDDDK
  • Fc
  • Avi
  • Flag
  • GST|His
  • HA
  • His (Fc)
  • His(C
  • ter)
  • His|T7
  • human|IgG1|Fc
  • N/A
  • N
  • hFc
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFSF13-1045H Active Recombinant Human TNFSF13 protein, HA-tagged HEK293 HA
Human TNFSF13-348H Active Recombinant Human TNFSF13 Mammalian cells N/A
Human TNFSF13-349H Active Recombinant Human TNFSF13, HA-tagged HEK293 HA
Human TNFSF13-350H Active Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Human N/A
Human TNFSF13-351H Active Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Human N/A
Human TNFSF13-399H Active Recombinant Human TNFSF13, FLAG-tagged HEK293 Flag
Human APRIL-3591H Recombinant Human APRIL Hi-5 Insect Cell N/A
Human TNFSF13-2141H Recombinant Human TNFSF13, Fc Chimera Mammalian Cell Fc
Human TNFSF13-2091H Recombinant Human TNFSF13, FLAG-tagged HEK293 Flag
Human TNFSF13-5106H Recombinant Human TNFSF13, T7-tagged E.coli T7
Human TNFSF13-505H Recombinant Human tumor necrosis factor (ligand) superfamily, member 13, T7 tagged E.coli T7
Human TNFSF13-875H Recombinant Human TNFSF13 Protein, GST-His-tagged E.coli GST/His
Human TNFSF13-318H Recombinant Active Human TNFSF13 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human TNFSF13-655H Recombinant Human TNFSF13 protein, His-tagged HEK293 His
Human TNFSF13-26H Active Recombinant Human TNFSF13 protein, His-Flag-tagged HEK293 His-Flag
Human TNFSF13-386H Recombinant Human TNFSF13 protein, Fc-tagged HEK293 human/IgG1/Fc
Human TNFSF13-1480H Recombinant Human TNFSF13 Protein (Met1-Leu250), N-His tagged E.coli N-His
Human TNFSF13-2885H Active Recombinant Human TNFSF13 protein, Fc-tagged HEK293 Fc
Human TNFSF13-4500H Recombinant Human TNFSF13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFSF13-142H Recombinant Human TNFSF13 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human TNFSF13-4500H-B Recombinant Human TNFSF13 Protein Pre-coupled Magnetic Beads HEK293
Human TNFSF13-5238H Recombinant Human TNFSF13 Protein (Ala105-Leu250), C-His tagged Mammalian cells C-His
Human TNFSF13-141H Recombinant Human TNFSF13 Protein, His-tagged Human Cells His
Human TNFSF13-304H Active Recombinant Human TNFSF13 Protein (Ala1-Leu146), C-His tagged, Animal-free, Carrier-free E.coli C-His
Human TNFSF13-2886H Active Recombinant Human TNFSF13 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
Human TNFSF13-2894H Recombinant Human TNFSF13 Protein (Pro1-Leu250), His tagged E.coli His
Mouse Tnfsf13-696M Active Recombinant Mouse Tnfsf13 CHO N/A
Mouse Tnfsf13-1744M Recombinant Mouse Tnfsf13 protein, His-tagged E.coli His
Mouse Tnfsf13-931M Recombinant Mouse Tnfsf13, Fc tagged Human Cell Fc
Mouse Tnfsf13-8691M Recombinant Mouse Tnfsf13 protein(Ala96-Leu240), hFc-tagged HEK293 N-hFc
Mouse Tnfsf13-933M Recombinant Mouse Tnfsf13 protein E.coli N/A
Mouse Tnfsf13-936M Recombinant Mouse Tnfsf13, Flag-tagged HEK293 Flag
Mouse Tnfsf13-930M Recombinant Murine Tnfsf13 E.coli N/A
Mouse TNFSF13-1346MCL Recombinant Mouse TNFSF13 cell lysate Human Cell N/A
Mouse Tnfsf13-155M Active Recombinant Mouse Tnfsf13 Protein E.coli
Mouse TNFSF13-2028M Recombinant Mouse TNFSF13 Protein E.coli N/A
Mouse Tnfsf13-440T Active Recombinant Mouse Tnfsf13 Protein (192 aa) E.coli
Rat Tnfsf13-16R Recombinant Rat Tnfsf13 Protein Yeast
Rat Tnfsf13-17R Recombinant Rat Tnfsf13 protein, His-tagged E.coli His
Rhesus monkey TNFSF13-1635R Recombinant Rhesus Monkey TNFSF13 Protein HEK293 N/A
Rhesus monkey TNFSF13-25R Recombinant Rhesus monkey TNFSF13 protein, His-tagged E.coli His
Rabbit TNFSF13-13R Recombinant Rabbit TNFSF13 Protein Yeast
Dog TNFSF13-1743D Recombinant Dog TNFSF13 protein, His-tagged E.coli His
Cattle TNFSF13-1742C Recombinant Cattle TNFSF13 protein, His & T7-tagged E.coli His/T7
Cynomolgus TNFSF13-754CB Recombinant Cynomolgus TNFSF13 protein, His-Avi-Flag-tagged, Biotinylated HEK293 His-Avi-Flag
Cynomolgus TNFSF13-2884C Active Recombinant Cynomolgus TNFSF13 protein, His-Flag-tagged HEK293 His-Flag
Cynomolgus TNFSF13-754C Recombinant Cynomolgus TNFSF13 protein, His-Avi-Flag-tagged HEK293 His-Avi-Flag
Rhesus Macaque TNFSF13-4873R Recombinant Rhesus monkey TNFSF13 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFSF13-4687R Recombinant Rhesus Macaque TNFSF13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TNFSF13-4687R-B Recombinant Rhesus Macaque TNFSF13 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TNFSF13-7646Z Recombinant Zebrafish TNFSF13 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNFSF13 Related Articles
  • TNFSF13 Related Gene Family
  • TNFSF13 Related Research Area
  • TNFSF13 Related Signal Pathway

TNFSF13 involved in several pathways and played different roles in them. We selected most pathways TNFSF13 participated on our site, such as Cytokine-cytokine receptor interaction, Intestinal i, ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCL7;IL4;GM2002;IL2RG;IRX1;ACVR1BA;ACVR2AA;MPL;TGFBR1
Intestinal iCXCL12B;CCL25;MHC2DCB;HLA-DQA2;MHC2DAB;HLA-DPB1;BMA1;HLA-DRB5;HLA-DPA1
ne network for IgA productionCD40LG;HLA-DRB4;CCR9A;H2-AA;HLA-DMB;TGFB1;BLB1;PIGR;TNFSF13
Rheumatoid arthritisIL1A;CXCL5;IL18;ATP6V1G1;ITGB2;ATP6V1B2;CCL20;ITGB2L;CCL2

TNFSF13 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF13 itself. We selected most functions TNFSF13 had, and list some proteins which have the same functions with TNFSF13. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIFNA10;Ccl12;IL26;INHBB;GDF10;FLT3LG;INHBC;HMGB1;IL21
receptor bindingMPV17L;ACOX2;Fert2;SRMS;AKAP9;CCDC129;PSPN;APP;FGF10A
tumor necrosis factor receptor bindingERAP1;TRAF6;TNFB;EDA;Fasl;TNFSF11;TNFSF15;TNFSF10L3;TNFSF12

TNFSF13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF13 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF13.

TNFRSF13B; KRAS; PIK3CA; CAMK1D

Osorio, C; Chacon, PJ; et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. MOLECULAR AND CELLULAR NEUROSCIENCE 59:24-36(2014).
Kutukculer, N; Gulez, N; et al. Three Different Classifications, B Lymphocyte Subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) Gene Mutations, CTLA-4 and ICOS Gene Polymorphisms in Turkish Patients with Common Variable Immunodeficiency. JOURNAL OF CLINICAL IMMUNOLOGY 32:1165-1179(2012).
TNF
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