TNFSF10

  • Official Full Name

    tumor necrosis factor (ligand) superfamily, member 10

  • Overview

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Synonyms

    TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human cells
  • Mammalian Cell
  • NS0
  • C
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • initial Met
  • mFc
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFSF10-635H Active Recombinant Human TNFSF10 Protein E.coli N/A
Human TNFSF10-4752H Active Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10 E.coli N/A
Human TNFSF10-306H Active Recombinant Human TNFSF10 Protein (Arg114-Gly281), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg114-Gly281
Human TNFSF10-01H Active Recombinant Human TNFSF10 Protein, His-Tagged NS0 His
Human TNFSF10-557H Recombinant Human TNFSF10, Fc tagged E.coli Fc
Human TNFSF10-302H Recombinant Human TNFSF10 Protein, His-tagged E.coli His
Human TNFSF10-31604TH Recombinant Human TNFSF10, FLAG-tagged E.coli Flag 187 amino acids
Human TNFSF10-2154H Recombinant Human TNFSF10, His-tagged E.coli His
Human TNFSF10-636H Recombinant Human TNFSF10 protein E.coli N/A Val114-Gly281
Human TNFSF10-556H Recombinant Human TNFSF10 protein, His-tagged E.coli His Val114~Gly281
Human TNFSF10-892HCL Recombinant Human TNFSF10 293 Cell Lysate HEK293 N/A
Human TNFSF10-220H Active Recombinant Human TNFSF10 protein, mFc-tagged HEK293 mFc Val 114 - Gly 281
Human TNFSF10-022HG Active GMP Recombinant Human TNFSF10 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human sTRAIL(NP_003801.1) was expressed with Fc tag at the C-terminal.
Human TNFSF10-253H Recombinant Human TNFSF10 Protein E.coli
Human TNFSF10-3603H Recombinant Human TNFSF10 protein, GST-tagged E.coli GST 39-281aa
Human TNFSF10-454H Recombinant Human TNFSF10 Protein, His-tagged E.coli N-His Thr39-Gly281
Human TNFSF10-151H Recombinant Human TNFSF10 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human TNFSF10-18H Human TNF-related Apoptosis-Inducing Ligand (trail) Reference standard N/A
Human TNFSF10-636HAF488 Recombinant Human TNFSF10 Protein, Met-tagged, Alexa Fluor 488 conjugated E.coli initial Met 169
Human TNFSF10-636HAF555 Recombinant Human TNFSF10 Protein, Met-tagged, Alexa Fluor 555 conjugated E.coli initial Met 169
Human TNFSF10-03H Active Recombinant Human TNFSF10 Protein (114-281), Tag-Free E.coli Tag Free 114-281
Human TNFSF10-0711H Recombinant Human TNFSF10 Protein (Met1-Gly281), C-His tagged E.coli C-His Met1-Gly281
Human TNFSF10-302T Active Recombinant Human TNFSF10 Protein (169 aa) E.coli 169
Human TNFSF10-636HAF647 Recombinant Human TNFSF10 Protein, Met-tagged, Alexa Fluor 647 conjugated E.coli initial Met 169
Human TNFSF10-2877H Recombinant Human TNFSF10 Protein (Thr95-Gly281), His tagged E.coli His Thr95-Gly281
Human TNFSF10-636HF Recombinant Human TNFSF10 Protein, Met-tagged, FITC conjugated E.coli initial Met 169
Mouse Tnfsf10-504M Active Recombinant Mouse Tnfsf10, His-tagged E.coli His
Mouse Tnfsf10-89M Active Recombinant Mouse Tnfsf10 Protein (Pro118-Asn291), C-His tagged, Animal-free, Carrier-free E.coli C-His Pro118-Asn291
Mouse TNFSF10-17171M Recombinant Mouse TNFSF10 Protein Mammalian Cell His
Mouse Tnfsf10-1509M Recombinant Mouse Tnfsf10 protein E.coli N/A 175
Mouse TNFSF10-851M Recombinant Mouse TNFSF10 protein(Pro118-Asn291), His-tagged E.coli N-His Pro118-Asn291
Mouse TNFSF10-851MF Recombinant Mouse TNFSF10 Protein, His-tagged, FITC conjugated E.coli His 190
Mouse Tnfsf10-6550M Active Recombinant Mouse Tnfsf10 Protein E.coli
Mouse TNFSF10-851MAF647 Recombinant Mouse TNFSF10 Protein, His-tagged, Alexa Fluor 647 conjugated E.coli His 190
Mouse TNFSF10-9480M Recombinant Mouse TNFSF10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNFSF10-851MAF555 Recombinant Mouse TNFSF10 Protein, His-tagged, Alexa Fluor 555 conjugated E.coli His 190
Mouse TNFSF10-9480M-B Recombinant Mouse TNFSF10 Protein Pre-coupled Magnetic Beads HEK293
Mouse TNFSF10-851MAF488 Recombinant Mouse TNFSF10 Protein, His-tagged, Alexa Fluor 488 conjugated E.coli His 190
Rat Tnfsf10-579R Recombinant Rat Tnfsf10 protein, His & GST-tagged E.coli His/GST Pro115~Ala287
Monkey TNFSF10-1191RAF647 Active Recombinant Monkey TNFSF10 Protein, Met-tagged, Alexa Fluor 647 conjugated E.coli initial Met 169
Monkey TNFSF10-1191RAF488 Active Recombinant Monkey TNFSF10 Protein, Met-tagged, Alexa Fluor 488 conjugated E.coli initial Met 169
Monkey TNFSF10-1191RAF555 Active Recombinant Monkey TNFSF10 Protein, Met-tagged, Alexa Fluor 555 conjugated E.coli initial Met 169
Monkey TNFSF10-1191RF Active Recombinant Monkey TNFSF10 Protein, Met-tagged, FITC conjugated E.coli initial Met 169
Rhesus monkey TNFSF10-1634R Recombinant Rhesus Monkey TNFSF10 Protein HEK293 N/A
Dog TNFSF10-577D Recombinant Dog TNFSF10 protein, His & T7-tagged E.coli His/T7 Thr36~Gly281 (Accession # F1PWB1)
Homo sapiens (Human) RFL33154HF Recombinant Full Length Human Tumor Necrosis Factor Ligand Superfamily Member 10(Tnfsf10) Protein, His-Tagged E.coli expression system His Full Length (1-281)
Rhesus TNFSF10-1191R Active Recombinant Rhesus TNFSF10 Protein E.coli N/A Val114-Gly281
Rhesus Macaque TNFSF10-4871R Recombinant Rhesus monkey TNFSF10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFSF10-4685R-B Recombinant Rhesus Macaque TNFSF10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TNFSF10-4685R Recombinant Rhesus Macaque TNFSF10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TNFSF10-710Z Recombinant Zebrafish TNFSF10 Mammalian Cell His
Chicken TNFSF10-5949C Recombinant Chicken TNFSF10 Mammalian Cell His
CSC-P0164 Anti-Human TRAIL MAb Stable Cell Line-CHO N/A
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFSF10 Related Signal Pathway

What is TNFSF10 protein?

TNFSF10 (TNF superfamily member 10) gene is a protein coding gene which situated on the long arm of chromosome 3 at locus 3q26. Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG.

What is the function of TNFSF10 protein?

TNFSF10 can bind to a variety of cell membrane death receptors, including TRAIL-R1 (DR4) and TRAIL-R2 (DR5), and activate apoptosis-related proteins such as caspase-8 and caspase-3, thereby inducing apoptosis of tumor cells, virus-infected cells and abnormal cells. It can also be involved in regulating immune cell functions, such as promoting T cell activation and proliferation or inhibiting the activation of the NF-κB signaling pathway, thereby reducing inflammation.

TNSF-7.jpg

Fig1. TRAIL/TRAIL-R signaling and NK cells.

TNFSF10 Related Signaling Pathway

In apoptosis signaling pathway, TNFSF10 can bind to TRAIL-R1 (DR4) and TRAIL-R2 (DR5) and activate apoptosis-related proteins. At the same time, there are other relevant signaling pathways including NF-κB signaling pathway related to inflammation, PI3K/Akt signaling pathway related to cell proliferation and apoptosis, Wnt/β-catenin signaling pathway and TGF-β signaling pathway.

TNFSF10 Related Diseases

It is involved in apoptosis pathways that can induce apoptosis of a variety of cancer cells, including lung cancer, breast cancer, colorectal cancer, stomach cancer, liver cancer, pancreatic cancer, etc. There are also autoimmune and inflammatory diseases associated with it.

Bioapplications of TNFSF10

A variety of TNFSF10 (TRAIL) receptor agonists with high affinity and stability have been developed to inhibit tumor growth and spread, thus providing new directions for tumor therapy.

Case study 1: Qing-Zhou Chen, 2020

TNSF-3.jpg

Fig1. HTNV NP and TRAIL-related apoptosis proteins expression in HTNV-infected HUVECs.

TNSF-4.jpg
Fig2. Immunofluorescence images of TUNEL assay on HTNV-infected HUVECs with rTRAIL treatment.
TNSF-6.jpg

Fig1. Schematic summarizing findings of let-7/TLR7/TRAIL induced neurodegeneration by ethanol. (Liya Qin, 2021)

TNFSF10 involved in several pathways and played different roles in them. We selected most pathways TNFSF10 participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionFLT4;OSM;TNFSF11;CCL4L2;CCL22;THPO;IL25;CCL6;IFNB
FoxO signaling pathwayPIK3CB;MAPK12A;CCND2;IRS2;STAT3;PRKAG3B;HRASA;MAP2K2B;SIRT1
ApoptosisIL1R1;HIST1H1E;GZME;DBNLB;CDK5RAP2;OCLN;BIRC8;PPP3CC;BCAP31
Natural killer cell mediated cytotoxicityCD247;PPP3CA;KRAS;Raet1c;PIK3R3;KIR2DS2;RAC3;MAP2K1;PRKCA
MeaslesIFNA2;OAS1;PRKCQ;EIF2AK2;Ifna11;IRF7;MAP3K7;IFNGR2;TRP53
Influenza AIFNA4;TLR7;MAPK9;MAPK10;GSK3B;RAE1;Ccl12;OAS2;PIK3R5

TNFSF10 has several biochemical functions, for example, cytokine activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF10 itself. We selected most functions TNFSF10 had, and list some proteins which have the same functions with TNFSF10. You can find most of the proteins on our site.

Function Related Protein
cytokine activityLEFTY2;IL15L;IL21;TNFSF13;Il1f8;BMP7;ILTIFB;CMTM2;Ccl27a
metal ion bindingNR4A2A;ZSWIM4;ZNF581;Gh;CYB561D2;ZFP488;CALUA;ADPGK;PRKCH
protein bindingOAS3;PPIL2;TNF;HBB;GOLPH3;TIMM50;DPCD;ASAP3;RBM39
receptor bindingNPFFL;ANGPTL2;HACL1;TDGF1;ADCYAP1;HLA-F;DRD1A;PEX14;BMP3
tumor necrosis factor receptor bindingBRE;TNFSF15;CASP8;TNFSF12;TNFSF14;TNFSF10;TRAF4;TRAF1;FASLG

TNFSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF10.

TNFRSF10B

Gene Family

TNF Cytokines

Research Area

Related articles

Cantarella, G; Di Benedetto, G; et al. Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease. BRAIN 138:203-216(2015).
Goere, D; Flament, C; et al. Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab. CANCER RESEARCH 73:4663-4673(2013).
  • Q&As
  • Reviews

Q&As (7)

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What is the therapeutic potential of TNFSF10 protein? 11/21/2021

TNFSF10 protein holds great therapeutic potential as a target for various diseases. Studies have shown that utilizing its apoptosis-inducing ability, novel treatment strategies can be developed for cancer. Furthermore, TNFSF10 protein can be utilized in the design of immunotherapies to enhance immune responses. However, further research is needed to optimize TNFSF10 therapeutic strategies and gain a deeper understanding of its specific mechanisms in disease development.

What is the cellular source of TNFSF10 protein? 01/07/2019

The cellular source of TNFSF10 protein is diverse, including tumor cells, lymphocytes, monocytes, and dendritic cells. Additionally, some epithelial cells and endothelial cells also express TNFSF10 protein.

What is the physiological function of TNFSF10 protein in tissue remodeling? 03/07/2018

TNFSF10 protein has diverse physiological functions in tissue remodeling. It promotes inflammation, angiogenesis, and fibrosis processes. Moreover, TNFSF10 protein is involved in immune regulation and tissue repair, playing a crucial role in maintaining normal tissue functionality and structure.

What cellular processes are modulated by TNFSF10? 01/24/2018

TNFSF10 modulates multiple cellular processes beyond apoptosis induction. It can activate various signaling pathways, including the NF-κB pathway, which plays a key role in immune and inflammatory responses. TNFSF10 also regulates cell migration and invasion properties, affecting metastasis in some cancer types. Furthermore, TNFSF10 can promote immune cell activation and cytokine production, contributing to the regulation of the immune system.

What is the role of TNFSF10 protein in cancer progression and metastasis? 10/27/2017

TNFSF10 protein plays a significant role in cancer progression and metastasis. It induces apoptosis in tumor cells, inhibits tumor growth and metastasis, and regulates immune responses. Moreover, TNFSF10 protein interacts with other signaling pathways, participating in the modulation of the tumor microenvironment.

What are the transcriptional regulatory mechanisms of TNFSF10 protein? 10/23/2017

The transcriptional regulation of TNFSF10 gene involves various factors. Known regulators include transcription factors NF-κB, STAT3, and DNA methylation status. These factors modulate the expression levels of TNFSF10 gene, thereby influencing the production of TNFSF10 protein.

What are the substrate interactions of TNFSF10 protein? 04/23/2016

TNFSF10 protein interacts with its receptor, death receptor 5 (DR5), and triggers apoptosis pathway to induce cell death. Additionally, TNFSF10 protein also interacts with other ligands and receptors, such as TRAIL-R1 and TRAIL-R2, thereby regulating cell survival and death signaling transduction.

Customer Reviews (3)

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09/19/2021

    Its quality exceeding imagination, this experimental reagent becomes an indispensable tool for my experiments.

    04/07/2020

      Through its employment, I am able to delve deeper into the essence of experimental principles and phenomena.

      07/21/2017

        The exceptional performance of this experimental reagent significantly enhances the visibility of my research and amplifies my scholarly impact.

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