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Official Full Name tumor necrosis factor (ligand) superfamily, member 10
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Synonyms TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human cells
    • Mammalian Cell
    • Tag :
    • Fc
    • Flag
    • His
    • GST
    • T7
    • Mouse IgG2a Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFSF10-151H Recombinant Human TNFSF10 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human TNFSF10-022HG GMP Recombinant Human TNFSF10 protein, Fc-tagged HEK293 Fc
    Human TNFSF10-18H Human TNF-related Apoptosis-Inducing Ligand (trail) Reference standard N/A
    Human TNFSF10-2154H Recombinant Human TNFSF10, His-tagged E.coli His
    Human TNFSF10-220H Recombinant Human TNFSF10 protein, Fc-tagged HEK293 Mouse IgG2a Fc
    Human TNFSF10-302H Recombinant Human TNFSF10 Protein, His-tagged E.coli His
    Human TNFSF10-31604TH Recombinant Human TNFSF10, FLAG-tagged E.coli Flag
    Human TNFSF10-4752H Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10 E.coli N/A
    Human TNFSF10-556H Recombinant Human TNFSF10 protein, His-tagged E.coli His
    Human TNFSF10-557H Recombinant Human TNFSF10, Fc tagged E.coli Fc
    Human TNFSF10-635H Recombinant Human TNFSF10 Protein E.coli N/A
    Human TNFSF10-636H Recombinant Human TNFSF10, None tagged E.coli N/A
    Human TNFSF10-892HCL Recombinant Human TNFSF10 293 Cell Lysate HEK293 N/A
    Mouse Tnfsf10-1509M Recombinant Mouse Tnfsf10 protein E.coli N/A
    Mouse TNFSF10-17171M Recombinant Mouse TNFSF10 Protein Mammalian Cell His
    Mouse Tnfsf10-504M Recombinant Mouse Tnfsf10, His-tagged E.coli His
    Mouse Tnfsf10-6550M Recombinant Mouse Tnfsf10 Protein E. coli
    Mouse TNFSF10-851M Recombinant Mouse TNFSF10 Protein, His-tagged E.coli His
    Rat Tnfsf10-579R Recombinant Rat Tnfsf10 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque TNFSF10-1191R Recombinant Rhesus TNFSF10 Protein E.coli N/A
    Rhesus monkey TNFSF10-1634R Recombinant Rhesus Monkey TNFSF10 Protein HEK293 N/A
    Rhesus Macaque TNFSF10-4871R Recombinant Rhesus monkey TNFSF10 Protein, His-tagged Mammalian Cell His
    Dog TNFSF10-577D Recombinant Dog TNFSF10 protein, His & T7-tagged E.coli His/T7
    Chicken TNFSF10-5949C Recombinant Chicken TNFSF10 Mammalian Cell His
    Zebrafish TNFSF10-710Z Recombinant Zebrafish TNFSF10 Mammalian Cell His
    CSC-P0164 Anti-Human TRAIL MAb Stable Cell Line-CHO N/A

    TNFSF10 involved in several pathways and played different roles in them. We selected most pathways TNFSF10 participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCR6A; IL13; THPO; RNF207B; EPO; IL15RA; IL15; PRL; IFNW1; TNFRSF25
    FoxO signaling pathway IRS2; BRAF; GABARAPL1; PIK3CB; PIK3R3B; IKBKB; SMAD3A; PDPK1; IL7R; MAPK14B
    Natural killer cell mediated cytotoxicity ICAM1; KLRC1; PTK2B; PLCG2; CD48; CD247; PIK3R1; KIR2DS4; IFNGR1; SHC2
    Measles STAT2; BBC3; PIK3R2; IFNA12; GSK3B; STAT5B; IRAK4; MSN; HSPA2; IL1A

    TNFSF10 has several biochemical functions, for example, cytokine activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF10 itself. We selected most functions TNFSF10 had, and list some proteins which have the same functions with TNFSF10. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity BMP8B; WNT5A; BMP15; IL23; TNFRSF11B; BMP2B; LEFTY1; Il1f8; GM13279; IFNB1
    metal ion binding XGB; MICAL2B; METAP2A; ZNF740; ZNF791; ARSG; PRKCHA; ZNF653; ZNF705A; NR1D4A
    protein binding HDC; CLCN1; TIPIN; VEPH1; TRAM2; MICALL1; CD5; INPP5K; CDA; TAF3
    receptor binding NSG1; PAOX; PPP2R4; ENSA; ZAP70; FIS1; PTK6B; CXCL1; LAMA4; IZUMO1
    tumor necrosis factor receptor binding TNFSF10; TRAP1; TRAF6; TNFSF14; TNF; CD70; LTB; TNFSF10L4; TNFSF8; TNFSF15

    TNFSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF10.


    Cantarella, G; Di Benedetto, G; et al. Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease. BRAIN 138:203-216(2015).
    Goere, D; Flament, C; et al. Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab. CANCER RESEARCH 73:4663-4673(2013).

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