TNFSF10
-
Official Full Name
tumor necrosis factor (ligand) superfamily, member 10
-
Overview
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] -
Synonyms
TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dog
- Homo sapiens (Human)
- Human
- Monkey
- Mouse
- Rat
- Rhesus
- Rhesus Macaque
- Rhesus monkey
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Human cells
- Mammalian Cell
- NS0
- Fc
- Flag
- GST
- His
- Avi
- T7
- mFc
- Non
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- TNFSF10 Related Signal Pathway
What is TNFSF10 protein?
TNFSF10 (TNF superfamily member 10) gene is a protein coding gene which situated on the long arm of chromosome 3 at locus 3q26. Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG.
What is the function of TNFSF10 protein?
TNFSF10 can bind to a variety of cell membrane death receptors, including TRAIL-R1 (DR4) and TRAIL-R2 (DR5), and activate apoptosis-related proteins such as caspase-8 and caspase-3, thereby inducing apoptosis of tumor cells, virus-infected cells and abnormal cells. It can also be involved in regulating immune cell functions, such as promoting T cell activation and proliferation or inhibiting the activation of the NF-κB signaling pathway, thereby reducing inflammation.
Fig1. TRAIL/TRAIL-R signaling and NK cells.
TNFSF10 Related Signaling Pathway
In apoptosis signaling pathway, TNFSF10 can bind to TRAIL-R1 (DR4) and TRAIL-R2 (DR5) and activate apoptosis-related proteins. At the same time, there are other relevant signaling pathways including NF-κB signaling pathway related to inflammation, PI3K/Akt signaling pathway related to cell proliferation and apoptosis, Wnt/β-catenin signaling pathway and TGF-β signaling pathway.
TNFSF10 Related Diseases
It is involved in apoptosis pathways that can induce apoptosis of a variety of cancer cells, including lung cancer, breast cancer, colorectal cancer, stomach cancer, liver cancer, pancreatic cancer, etc. There are also autoimmune and inflammatory diseases associated with it.
Bioapplications of TNFSF10
A variety of TNFSF10 (TRAIL) receptor agonists with high affinity and stability have been developed to inhibit tumor growth and spread, thus providing new directions for tumor therapy.
High Purity
Fig1. SDS-PAGE (TNFSF10-556H) (PROTOCOL for western blot)
.
Fig2. SDS-PAGE (TNFSF10-454H) (PROTOCOL for western blot)
Case study 1: Qing-Zhou Chen, 2020
Fig1. HTNV NP and TRAIL-related apoptosis proteins expression in HTNV-infected HUVECs.
TNFSF10 involved in several pathways and played different roles in them. We selected most pathways TNFSF10 participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | KITLGA;CRLF2;IL-8;CX3CR1;HGF;PDGFC;TNFSF9;IL17RA;BMPR2A |
| FoxO signaling pathway | NLK1;PIK3CD;MAPK14B;ARAF;SOD2;PRKAB1;BNIP4;SKP2;TNFSF10 |
| Apoptosis | IRF2;NFKB1;FADD;Fasl;STK24A;BADB;HMGB2;AIFM1;TNFSF10 |
| Natural killer cell mediated cytotoxicity | GM-CSF;IFNA6;PRKCB;NCR3;KIR2DS4;FCGR3B;KLRC4-KLRK1;HLA-A;TNFSF10 |
| Measles | TRP53;PIK3R5;OAS2;IL12A;RELA;IRAK1;TLR9;CD209B;BBC3 |
| Influenza A | HLA-DOA;PABPN1;LOC100686744;RAF1;EP300;IFNA17;HNRNPUL1;IFNA3;BMA1 |
TNFSF10 has several biochemical functions, for example, cytokine activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF10 itself. We selected most functions TNFSF10 had, and list some proteins which have the same functions with TNFSF10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CMTM8;IFNA8;IL36G;BMP6;IL15L;GM13289;PRL7D1;IFNG1-1;Il1f8 |
| metal ion binding | ITGA8;ZFP932;MYLIPA;CARS;ZNF554;ARSD;IMPDH1;ETFDH;FGD6 |
| protein binding | PPP2R4;MRTO4;SENP5;SNRNP25;ASGR2;ARRB2;EPHB1;BBS4;OBFC2B |
| receptor binding | AMH;FASLG;TNFSF9;TAC1;MCHR1;C5;FKBP1B;PVRL2;F2R |
| tumor necrosis factor receptor binding | Fasl;TRADD;TRAF1;TRAF3;TRAF2;TRAF6;TNFSF13;TNFSF9;TNFSF12 |
TNFSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF10.
TNFRSF10B
Gene Family
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewIts quality exceeding imagination, this experimental reagent becomes an indispensable tool for my experiments.
Through its employment, I am able to delve deeper into the essence of experimental principles and phenomena.
The exceptional performance of this experimental reagent significantly enhances the visibility of my research and amplifies my scholarly impact.
Q&As (7)
Ask a questionTNFSF10 protein holds great therapeutic potential as a target for various diseases. Studies have shown that utilizing its apoptosis-inducing ability, novel treatment strategies can be developed for cancer. Furthermore, TNFSF10 protein can be utilized in the design of immunotherapies to enhance immune responses. However, further research is needed to optimize TNFSF10 therapeutic strategies and gain a deeper understanding of its specific mechanisms in disease development.
The cellular source of TNFSF10 protein is diverse, including tumor cells, lymphocytes, monocytes, and dendritic cells. Additionally, some epithelial cells and endothelial cells also express TNFSF10 protein.
TNFSF10 protein has diverse physiological functions in tissue remodeling. It promotes inflammation, angiogenesis, and fibrosis processes. Moreover, TNFSF10 protein is involved in immune regulation and tissue repair, playing a crucial role in maintaining normal tissue functionality and structure.
TNFSF10 modulates multiple cellular processes beyond apoptosis induction. It can activate various signaling pathways, including the NF-κB pathway, which plays a key role in immune and inflammatory responses. TNFSF10 also regulates cell migration and invasion properties, affecting metastasis in some cancer types. Furthermore, TNFSF10 can promote immune cell activation and cytokine production, contributing to the regulation of the immune system.
TNFSF10 protein plays a significant role in cancer progression and metastasis. It induces apoptosis in tumor cells, inhibits tumor growth and metastasis, and regulates immune responses. Moreover, TNFSF10 protein interacts with other signaling pathways, participating in the modulation of the tumor microenvironment.
The transcriptional regulation of TNFSF10 gene involves various factors. Known regulators include transcription factors NF-κB, STAT3, and DNA methylation status. These factors modulate the expression levels of TNFSF10 gene, thereby influencing the production of TNFSF10 protein.
TNFSF10 protein interacts with its receptor, death receptor 5 (DR5), and triggers apoptosis pathway to induce cell death. Additionally, TNFSF10 protein also interacts with other ligands and receptors, such as TRAIL-R1 and TRAIL-R2, thereby regulating cell survival and death signaling transduction.
Ask a Question for All TNFSF10 Products
Required fields are marked with *
My Review for All TNFSF10 Products
Required fields are marked with *
