|Official Full Name||tumor necrosis factor (ligand) superfamily, member 10|
|Background||The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]|
|Synonyms||TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TNFSF10 involved in several pathways and played different roles in them. We selected most pathways TNFSF10 participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||CCR6A; IL13; THPO; RNF207B; EPO; IL15RA; IL15; PRL; IFNW1; TNFRSF25|
|FoxO signaling pathway||IRS2; BRAF; GABARAPL1; PIK3CB; PIK3R3B; IKBKB; SMAD3A; PDPK1; IL7R; MAPK14B|
|Apoptosis||DBNLA; CASP3A; TNFRSF10C; BCAP31; IL1B2; ADD1; NGF; BAXB; HIST1H1B; PIK3CG|
|Natural killer cell mediated cytotoxicity||ICAM1; KLRC1; PTK2B; PLCG2; CD48; CD247; PIK3R1; KIR2DS4; IFNGR1; SHC2|
|Measles||STAT2; BBC3; PIK3R2; IFNA12; GSK3B; STAT5B; IRAK4; MSN; HSPA2; IL1A|
|Influenza A||HLA-DPB1; NFKBIB; IL8L2; PRSS1; PYCARD; IFNA5; BMA2; FAS; VDAC1; TMPRSS13|
TNFSF10 has several biochemical functions, for example, cytokine activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF10 itself. We selected most functions TNFSF10 had, and list some proteins which have the same functions with TNFSF10. You can find most of the proteins on our site.
|cytokine activity||BMP8B; WNT5A; BMP15; IL23; TNFRSF11B; BMP2B; LEFTY1; Il1f8; GM13279; IFNB1|
|metal ion binding||XGB; MICAL2B; METAP2A; ZNF740; ZNF791; ARSG; PRKCHA; ZNF653; ZNF705A; NR1D4A|
|protein binding||HDC; CLCN1; TIPIN; VEPH1; TRAM2; MICALL1; CD5; INPP5K; CDA; TAF3|
|receptor binding||NSG1; PAOX; PPP2R4; ENSA; ZAP70; FIS1; PTK6B; CXCL1; LAMA4; IZUMO1|
|tumor necrosis factor receptor binding||TNFSF10; TRAP1; TRAF6; TNFSF14; TNF; CD70; LTB; TNFSF10L4; TNFSF8; TNFSF15|
TNFSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF10.