tnfsf4
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  • Official Full Name
  • tumor necrosis factor (ligand) superfamily, member 4
  • Background
  • OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
  • Synonyms
  • TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l; CD134L; CD 252; CD134; CD134 ligand; CD134L; CD252; CD252 antigen; glycoprotein 34 kd; glycoprotein Gp34; GP34; OX-40L; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFL4; TNFSF4; tumor necrosis factor ligand superfamily member 4; TXGP1; tumor necrosis factor (ligand) superfamily, member 4
Cat.#:TNFSF4-344HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF4 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:TNFSF4-345RTag:MIgG2a Fc
Source (Host):HEK293Species:Rhesus Monkey
Product nameRecombinant Rhesus Monkey TNFSF4 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:TNFSF4-886MTag:MIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Mouse TNFSF4 Protein (Gln49-Leu198), MIgG1 Fc-tagged
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Cat.#:TNFSF4-887MTag:RlgG Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFSF4 Protein (Gln49-Leu198), RlgG Fc-tagged
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Cat.#:TNFSF4-2259HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF4 Protein, MYC/DDK-tagged
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Cat.#:TNFSF4-27254THTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human TNFSF4
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Cat.#:TNFSF4-272HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF4, His-tagged
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Cat.#:TNFSF4-490HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF4 Protein, Fc-tagged
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Cat.#:Tnfsf4-20MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf4 protein, Fc-tagged
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Cat.#:Tnfsf4-21MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf4 protein, His-tagged
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Cat.#:Tnfsf4-407MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf4, FLAG-tagged
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Cat.#:TNFSF4-6204RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNFSF4 Protein
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Cat.#:TNFSF4-67CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF4, Fc tagged
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Cat.#:TNFSF4-85CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF4, Fc-tagged
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Cat.#:Tnfsf4-2074MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf4, FLAG-tagged
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Cat.#:TNFSF4-857CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFSF4 cell lysate
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Involved Pathway

Tnfsf4 involved in several pathways and played different roles in them. We selected most pathways Tnfsf4 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfsf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFSF9; TGFB1A; BMPR1AB; IL2RG; CCR10; IL20RA; CXCR7; IL13; IL12B; CCL1

Protein Function

Tnfsf4 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfsf4 itself. We selected most functions Tnfsf4 had, and list some proteins which have the same functions with Tnfsf4. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IFNG1-1; IFNE; OSTN; LTB; IFNPHI3; IFNA21; CER1; FLT3LG; GDF15; IL33
Function receptor binding
Related Protein NOS2; NTF3; RCHY1; HTT; ANGPTL1; CD86; ECI2; EHHADH; ARPP19A; FLT3LG
Function tumor necrosis factor receptor binding
Related Protein TNFSF10L; LTA; TRAF2; TNFSF13; CASP8; BRE; FADD; TNF; TNFSF9; TNFSF15
Function tumor necrosis factor receptor superfamily binding
Related Protein TNFSF18; TNFSF4; FADD; TNFSF9; TNFSF11

Tnfsf4 Related Articles

Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
Mahlios, J; De la Herran-Arita, AK; et al. The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY 23:767-773(2013).

Tnfsf4 Related Gene Family

TNF Cytokines