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Active Recombinant Mouse Tnfsf4, FLAG-tagged

Cat.No. : Tnfsf4-407M
Product Overview : The extracellular domain of mouse OX40L (aa 52-199) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG-tag.
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Description : OX40L [CD252; CD134L] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. MegaOX40L is a high activity construct in which two trimeric OX40L ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively activates T cell proliferation.
Source : HEK293 Cells
Species : Mouse
Tag : FLAG
Form : Lyophilized. Contains PBS.
Bio-activity : Activates T cell proliferation.
Molecular Mass : ~40kDa (SDS-PAGE)
Purity : ≥90% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Concentration : 0.1mg/ml after reconstitution.
Gene Name : Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 [ Mus musculus ]
Official Symbol : Tnfsf4
Synonyms : TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l;
Gene ID : 22164
mRNA Refseq : NM_009452
Protein Refseq : NP_033478
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine activity; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor superfamily binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do genetic variations in TNFSF4 affect immune function? 01/09/2022

Genetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.

What is the primary role of TNFSF4 in immune system regulation? 08/16/2021

TNFSF4 (OX40L) regulates immune responses and T-cell activation.

How does TNFSF4 contribute to inflammatory responses? 05/11/2020

It activates T-cells, stimulating inflammatory cytokine production.

What role does TNFSF4 play in autoimmune disorders? 09/12/2019

TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.

How does TNFSF4 interact with other cytokines and receptors in the immune system? 06/09/2019

TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.

What potential therapeutic applications arise from targeting TNFSF4 in immune-related diseases? 10/04/2018

Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.

What is the impact of altered TNFSF4 activity on chronic inflammation? 03/29/2017

Altered TNFSF4 activity contributes to chronic inflammation.

Customer Reviews (3)

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Reviews
12/28/2022

    Efficient service, accelerates research productivity.

    05/13/2018

      Outstanding accuracy, essential for research quality.

      02/12/2018

        Trusted for research integrity, a critical research asset.

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