| Description : |
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
72.7 kDa |
| Protein Length : |
761 |
| AA Sequence : |
MALPALGLDPWSLLGLFLFQLLQLL LPTTTAGGGGQGPMPRVRYYAGDER RALSFFHQKGLQDFDTLLLSGDGNT LYVGAREAILALDIQDPGVPRLKNM IPWPASDRKKSECAFKKKSNETQCF NFIRVLVSYNVTHLYTCGTFAFSPA CTFIELQDSYLLPISEDKVMEGKGQ SPFDPAHKHTAVLVDGMLYSGTMNN FLGSEPILMRTLGSQPVLKTDNFLR WLHHDASFVAAIPSTQVVYFFFEET ASEFDFFERLHTSRVARVCKNDVGG EKLLQKKWTTFLKAQLLCTQPGQLP FNVIRHAVLLPADSPTAPHIYAVFT SQWQVGGTRSSAVCAFSLLDIERVF KGKYKELNKETSRWTTYRGPETNPR PGSCSVGPSSDKALTFMKDHFLMDE QVVGTPLLVKSGVEYTRLAVETAQG LDGHSHLVMYLGTTTGSLHKAVVSG DSSAHLVEEIQLFPDPEPVRNLQLA PTQGAVFVGFSGGVWRVPRANCSVY ESCVDCVLARDPHCAWDPESRTCCL LSAPNLNSWKQDMERGNPEWACASG PMSRSLRPQSRPQIIKEVLAVPNSI LELPCPHLSALASYYWSHGPAAVPE ASSTVYNGSLLLIVQDGVGGLYQCW ATENGFSYPVISYWVDSQDQTLALD PELAGIPREHVKVPLTRVSGGAALA AQQSYWPHFVTVTVLFALVLSGALI ILVASPLRALRARGKVQGCETLRPG EKAPLSREQHLQSPKECRTSASDVD ADNNCLGTEVA |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
