Active Recombinant Mouse Casp1 Protein

• Cat.No.: Casp1-0413M
• Product Overview: Mouse Casp1 (P29452) recombinant protein expressed in Escherichia coli. This protein composed of large (20 KDa) and small (10 KDa) KDa) subunits.

Specification

• Description: Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.
• Source: E. coli
• Species: Mouse
• Form: Lyophlized
• Bio-activity: 20000 units/mg
• Molecular Mass: 30 kDa
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade on dry atmosphere. After reconstitution with PBS containing 15% glycerol 1 uL per unit, store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: No additive

Gene Information

• Gene Name: Casp1 caspase 1 [ Mus musculus ]
• Official Symbol: Casp1
• Synonyms: CASP1; caspase 1; caspase-1; p45; CASP-1; IL-1BC; IL-1B converting enzyme; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin 1 beta-converting enzyme; interleukin-1 beta-converting enzyme; ICE; Il1bc
• Gene ID: 12362
• mRNA Refseq: NM_009807
• Protein Refseq: NP_033937

Reviews

09/14/2022

Fast delivery, reliable results.

01/21/2022

Very high-quality product.

07/28/2021

Great for protein research.

Q&As

How does CASP1 contribute to the regulation of the inflammatory response?

It processes pro-inflammatory cytokines to their active forms, modulating inflammation.

What therapeutic strategies are being explored targeting CASP1 for disease treatment?

Therapeutic strategies include CASP1 inhibitors, aiming to reduce inflammation in diseases like cryopyrin-associated periodic syndromes (CAPS).

What role does CASP1 play in the maturation and secretion of pro-inflammatory cytokines?

It is essential for the maturation and secretion of IL-1β and IL-18, pro-inflammatory cytokines.

In which cells or tissues is CASP1 predominantly expressed?

CASP1 is predominantly expressed in immune cells like macrophages and dendritic cells.

Are there known genetic mutations in CASP1 associated with specific diseases?

Genetic mutations in CASP1 have been associated with increased susceptibility to certain infectious and inflammatory diseases.

How is CASP1 implicated in the pathogenesis of autoinflammatory diseases?

Dysregulation of CASP1 is linked to autoinflammatory diseases, causing excessive inflammation.

What is the primary biological function of CASP1 in cells?

CASP1 is a protease that plays a critical role in the initiation of apoptosis and inflammation.