casp9

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casp9

Official Full Name caspase 9, apoptosis-related cysteine peptidase
Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Synonyms CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP9-0433H Recombinant Human CASP9 Protein, GST-Tagged Wheat Germ GST
    Human CASP9-148H Recombinant Human CASP9 Protein, His-tagged E.coli His
    Human CASP9-3270H Recombinant Human CASP9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CASP9-34H Recombinant Human Caspase-9 Enzyme N/A
    Human CASP9-48H Recombinant Human CASP9 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CASP9-49H Recombinant Human CASP9 protein E.coli N/A
    Human CASP9-584H Recombinant Human CASP9 Mammalian Cell His
    Human CASP9-618H Recombinant Human CASP9 E.coli N/A
    Human CASP9-626H Recombinant Human CASP9 protein, His-tagged E.coli His
    Human CASP9-627H Recombinant Human CASP9 protein, His-tagged E.coli His
    Human CASP9-7828HCL Recombinant Human CASP9 293 Cell Lysate HEK293 N/A
    Mouse CASP9-2758M Recombinant Mouse CASP9 Protein Mammalian Cell His
    Mouse Casp9-628M Recombinant Mouse Casp9 protein, His-tagged E.coli His
    Mouse Casp9-679M Recombinant Mouse Caspase 9 E.coli N/A
    Mouse Casp9-773M Recombinant Mouse Casp9 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Casp9-629R Recombinant Rat Casp9 protein, His-tagged E.coli His
    Zebrafish CASP9-1788Z Recombinant Zebrafish CASP9 Mammalian Cell His

    casp9 involved in several pathways and played different roles in them. We selected most pathways casp9 participated on our site, such as p signaling pathway, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with casp9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p signaling pathway RRM2; CASP8; APAF1; BID; ATM; PTENB; BBC3; BAI1; PPM1DA; PERP
    PIK-Akt signaling pathway IFNAR2; EPOR; YWHAB; PPP2R5C; IFNA7; HGF; EIF4E2; KITLG; TLR2; GYS1
    Apoptosis PTBP3; BOKA; DFFA; CASP6L2; IL3RA; DBNLA; APAF1; CLSPN; MAP3K14; BCAP31
    VEGF signaling pathway MAP2K1; SPHK1; SPHK2; MAPKAPK2; PIK3R3B; SHC2; PLCG1; HRAS; PRKCBB; PIK3CD
    Thyroid hormone signaling pathway PRKACG; PFKFB2; PLCG2; PIK3CA; RXRA; GSK3B; PLCD4; KRAS; TSC2; HDAC1
    Alzheimers disease IDE; IL1B; COX7A2L; CHP; PLCB1; GRIN1; ATP5B; IL1B2; UQCRC1; CDK5R1
    Parkinsons disease UBA1; COX7B2; UBE2L3; NDUFC2; TH; UQCRQ; UQCRFS1; UQCR11; UQCRH; MT-ATP6
    Amyotrophic lateral sclerosis (ALS) TP53; SLC1A2; NOS1; GRIN1; MAPK13; GPX1; PPP3R1; BID; CAT; PRPH
    Huntingtons disease COX8C; COX7C; PLCB2; POLR2C; POLR2B; ATP5A1; TBPL2; VDAC2; DNAI2; ITPR1
    Legionellosis IL6; ITGB2L; HSPA1B; IL-8; HBS1L; CLK1; TLR2; SAR1B; IL1B; ITGAM
    Toxoplasmosis NFKBIA; MAPK13; CD40; TGFB1; HLA-DRA; HLA-DOA; CYCS; IFNG; BIRC3; LAMA2
    Tuberculosis IRAK4; TLR2; IFNA16; RAB5B; ATP6V0A2; NFYC; PPP3R1; HLA-DMB; CALML5; IFNA5
    Hepatitis B Ifna11; TIRAP; TGFB3; HRAS; IFNA21; BAD; MAPK8; PIK3CD; EP300; GRB2
    Influenza A TYK2; PRKCB; IL-8; NUP98; PIK3R5; TLR4; GSK3B; FASLG; MAPK3; MAPK13
    Pathways in cancer RASSF1; NCOA4; PLCB2; EGLN3; FLT3LG; STK4; BIRC8; WNT2; FGFR2; CXCL12
    Colorectal cancer TGFB2; TGFB3; PIK3CG; MLH1; BIRC5; LEF1; TRP53; TGFBR1; MSH6; PIK3R2
    Pancreatic cancer TGFBR2; MAP2K1; RELA; RAC2; RALBP1; CASP9; AKT1; STAT1; PIK3R5; MAPK9
    Endometrial cancer PDPK1; PIK3CG; PIK3R5; ERBB2; TRP53; TCF7; AKT2; PIK3R2; AKT1; SOS1
    Prostate cancer HSP90B1; TCF7; INSRR; PIK3CB; SPRY1; FOXA1; IKBKG; PIK3R3; INS; NKX3-1
    Small cell lung cancer TRAF4; LAMA3; LAMB1; PIK3CB; APAF1; TRAF2; AKT1; ITGA3; SKP2; PIK3CG
    Non-small cell lung cancer RXRG; FOXO3; RARB; PIK3CB; PLCG2; RXRB; TP53; PDPK1; PLCG1; AKT1
    Viral myocarditis ITGAL; RAC1; ACTG1; SGCD; HLA-DPB1; EIF4G3; HLA-G; EIF4G2; CD40LG; HLA-DRA

    casp9 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by casp9 itself. We selected most functions casp9 had, and list some proteins which have the same functions with casp9. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding ARHGAP1; PTPN22; LYN; INPP5J; PTPN12; ABI2; DOCK4; CCDC6; QK; SOS1
    cysteine-type endopeptidase activity USP51; BLMH; CASP10; CTSLL; USP13; CASP6L1; USP2; MALT1A; CTSL1; CASP2
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway CASP9; CFLAR; CASP10; CFLARA; CASP14; CASP2; CASP8L1; CASP8
    enzyme activator activity PITRM1; MMP16; ASAP2; ALOX5AP; MMP15; MGST2; ALDH1A2; TAB1; TRIM23; CTAGE5
    peptidase activity KLK7; lon; KLK1B11; Casp3; Acr; THSD4; FAM49BA; SPCS3; F2RL1.2; ADAMTS16
    protein binding CEBPB; NUP133; CHRAC1; IKZF1; KCP; CTNND1; DKK1; Reln; IKZF2; SERPING1
    protein kinase binding KIF11; LLGL1; CRY1; PDGFRB; DAXX; SHC1; RPS6KA3; CDKN2B; SHC3; MAVS

    casp9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with casp9 here. Most of them are supplied by our site. Hope this information will be useful for your research of casp9.

    XIAP; APAF1

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