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CASP12

  • Official Full Name

    caspase 12 (gene/pseudogene)

  • Overview

    The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
  • Synonyms

    CASP12; UNQ9415; Apoptosis related cysteine protease; CASP 12; CASP-12; CASP12P1; Caspase 12 pseudogene 1; Caspase12; CASPC_HUMAN; Inactive caspase-12; inactive caspase-12-like; EC 3.4.22;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP12-897H Recombinant Human CASP12 Mammalian Cell His
Human CASP12-622H Recombinant Human CASP12 Protein, His&SUMO-tagged E.coli N-His&SUMO Leu101-Leu337
Human CASP12-2592H-B Recombinant Human CASP12 Protein Pre-coupled Magnetic Beads HEK293
Human CASP12-2592H Recombinant Human CASP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CASP12-2749M Recombinant Mouse CASP12 Protein Mammalian Cell His
Mouse Casp12-779M Recombinant Mouse Casp12 protein, His & GST-tagged E.coli His/GST Met1~Phe413 (Accession # O08736)
Mouse CASP12-1241M-B Recombinant Mouse CASP12 Protein Pre-coupled Magnetic Beads HEK293
Mouse CASP12-1241M Recombinant Mouse CASP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CASP12-1143R Recombinant Rat CASP12 Protein Mammalian Cell His
Rat Casp12-780R Recombinant Rat Casp12 protein, His & T7-tagged E.coli His/T7 Met1~Thr244 (Accession # Q920D5)
Rat CASP12-801R Recombinant Rat CASP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CASP12-801R-B Recombinant Rat CASP12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CASP12-633R Recombinant Rhesus monkey CASP12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CASP12-461R Recombinant Rhesus Macaque CASP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CASP12-461R-B Recombinant Rhesus Macaque CASP12 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CASP12 Related Research Area

CASP12 involved in several pathways and played different roles in them. We selected most pathways CASP12 participated on our site, such as Alzheimers disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseATP2A2;ATF6;ATP5B;NOS1;NDUFA4;MT-ATP6;SDHC;COX6A2;PPP3R1
Amyotrophic lateral sclerosis (ALS)BAX;CASP12;PPP3CB;PRPH;TNFRSF1B;DERL1;SOD1;CYCS;TNFRSF1A
ApoptosisDNM1L;TNF;BIDA;PPP3CB;HIST1H1C;CASP2;LMNB1;CYCSB;HIST1H1E
Corticotropin-releasing hormoneECE1;TRIM28;TBX19;TCF4;CYP11A1;ADRBK2;KRT1;TFAP2A;KRT14
Hepatitis BPIK3CB;IFNA13;GRB2;VDAC3;EP300;MYD88;STAT6;IFN-a;YWHAZ
Integrated Pancreatic Cancer PathwayLEFTY1;MYT1;DAXX;GPRC5A;JUND;RAPGEF3;AGA;TFF1;NOXA1
Prion diseasesC1QB;C1QA;PRKACA;Hc;C8G;ELK1;C5;NOTCH1;NCAM2

CASP12 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in apoptotic process, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP12 itself. We selected most functions CASP12 had, and list some proteins which have the same functions with CASP12. You can find most of the proteins on our site.

Function Related Protein
NOT cysteine-type endopeptidase activity involved in apoptotic process
NOT cysteine-type endopeptidase activity involved in execution phase of apoptosisCASP1;CASPBL;CASP5;CASP12;PSD;CASPA;CASP4;CASPB

CASP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP12.

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