CASP12 Protein


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Official Full Name caspase 12 (gene/pseudogene)
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Synonyms CASP12; UNQ9415; Apoptosis related cysteine protease; CASP 12; CASP-12; CASP12P1; Caspase 12 pseudogene 1; Caspase12; CASPC_HUMAN; Inactive caspase-12; inactive caspase-12-like; EC 3.4.22
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • GST
    • T7
    • N-His&SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP12-897H Recombinant Human CASP12 Mammalian Cell His
    Mouse CASP12-2749M Recombinant Mouse CASP12 Protein Mammalian Cell His
    Mouse Casp12-779M Recombinant Mouse Casp12 protein, His & GST-tagged E.coli His/GST
    Rat CASP12-1143R Recombinant Rat CASP12 Protein Mammalian Cell His
    Rat Casp12-780R Recombinant Rat Casp12 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CASP12-633R Recombinant Rhesus monkey CASP12 Protein, His-tagged Mammalian Cell His
    Human CASP12-622H Recombinant Human CASP12 Protein, His&SUMO-tagged E.coli N-His&SUMO

    CASP12 involved in several pathways and played different roles in them. We selected most pathways CASP12 participated on our site, such as Alzheimers disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease PPP3CB; CASP9; NDUFB4; CALM1; NDUFB7; COX8C; NDUFB8; ATP5A1; ATP5G3; ITPR2
    Amyotrophic lateral sclerosis (ALS) BID; MAPK14; GRIN2B; TNF; BCL2; TP53; TRP53; CASP1; PPP3CB; PRPH
    Corticotropin-releasing hormone PARP1; KRT14; ECE1; JUND; KRT1; CYP11A1; CRHBP; ADRBK2; CRH; IVL
    Hepatitis B CASP10; SRC; IL-8; IFNA16; ATP6AP1; MAVS; APAF1; PIK3CB; STAT4; TLR3
    Integrated Pancreatic Cancer Pathway JUND; LEFTY1; MYT1; IL11; BRF1; CST3; CASP12; AGA; TOP1; PPP1R13L
    Prion diseases C1QB; IL6; C5; C9; C8A; IL1A; MAP2K2; C8G; SOD1; C8B

    CASP12 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in apoptotic process, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP12 itself. We selected most functions CASP12 had, and list some proteins which have the same functions with CASP12. You can find most of the proteins on our site.

    Function Related Protein
    NOT cysteine-type endopeptidase activity involved in apoptotic process CASP12
    NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis CASP5; CASPB; CASPA; CASP1; CASP4; CASPBL; PSD; CASP12

    CASP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP12.


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