Casp3

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Casp3

Official Full Name caspase 3, apoptosis-related cysteine peptidase
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Synonyms CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Wheat Germ
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MBP
    • T7
    • Met
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP3-01H Recombinant Human CASP3 Protein, His-tagged E.coli His
    Human CASP3-0421H Recombinant Human CASP3 Protein, GST-Tagged Wheat Germ GST
    Human CASP3-1333H Recombinant Human CASP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CASP3-158H Recombinant Human CASP3 E.coli N/A
    Human CASP3-1642H Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP3-188H Recombinant Human CASP3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human CASP3-192H Recombinant Human CASP3, Met&His-tagged E.coli Met/His
    Human CASP3-293H Recombinant Human CASP3 protein, His/MBP-tagged E.coli His/MBP
    Human CASP3-334H Recombinant Human CASP3 protein, GST-tagged Human Wheat Germ GST
    Human CASP3-342H Recombinant Human CASP3, His tagged E.coli His
    Human CASP3-36H Recombinant Human CASP3, His-tagged E.coli His
    Human CASP3-621H Recombinant Human CASP3 protein, His-tagged E.coli His
    Human CASP3-622H Recombinant Human CASP3 protein, His & T7-tagged E.coli His/T7
    Human CASP3-7838HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
    Human CASP3-7839HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
    Mouse Casp3-1641M Recombinant Mouse Caspase 3 E.coli N/A
    Mouse Casp3-1643M Recombinant Mouse Casp3 protein E.coli N/A
    Mouse Casp3-623M Recombinant Mouse Casp3 protein, His-tagged E.coli His
    Mouse Casp3-771M Recombinant Mouse Casp3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CASP3-1145R Recombinant Rat CASP3 Protein Mammalian Cell His
    Rat Casp3-624R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7
    Rat Casp3-625R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7
    Rat Casp3-748R Recombinant Rat Caspase 3, His-tagged E.coli His
    Cynomolgus Monkey CASP3-362C Recombinant Cynomolgus CASP3 Protein, His-tagged Mammalian Cell His
    Chicken CASP3-6290C Recombinant Chicken CASP3 Mammalian Cell His
    CBCRY39 Caspase-3 E.coli N/A

    Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway ARRB1; IKBKB; TGFBR2; RAC2; PTPRR; PDGFB; ACVR1C; CACNA1D; CACNB4; MAX
    p signaling pathway SIAH2L; CCND2; SERPINB5; PPM1DA; IGF1; RRM2B; CDK1; TP53I3; BID; CASP3A
    Apoptosis TICAM1; DBNL; BMX; IL1R1; CFLARA; YWHAQ; ATM; STK24B; HMGB2A; DIABLOB
    Natural killer cell mediated cytotoxicity PIK3CG; MAP2K1; PRKCA; RAC3; KIR2DS3; PPP3CA; PTPN11; NCR1; IFNA8; RAET1D
    TNF signaling pathway CREB3L1; CFLAR; MAGI2; TNFRSF1A; LTA; PIK3CG; RPS6KA5; BCL3; CCL2; MAPK13
    Serotonergic synapse GNG10; CYP2D9; ITPR1; MAOA; ALOX12; PRKACG; GNB4; GNAS; MAPK3; PLA2G4A
    Non-alcoholic fatty liver disease (NAFLD) PIK3CB; PIK3R2; NDUFA5; NDUFV3; NDUFS6; KCNA3; IL1B; NDUFA9; NDUFS2; PRKAB1
    Alzheimers disease SNCA; UQCRB; CALM3; GNAQ; UQCRFS1; NDUFS3; IL1B2; NDUFS8; BACE1; Atp5g2
    Parkinsons disease SLC25A4; NDUFA8; PARK7; Casp3; PARK2; NDUFC2-KCTD14; GNAI1; UBE2J2; NDUFS7; ATP5G1
    Amyotrophic lateral sclerosis (ALS) DERL1; MAPK12; PPP3CC; TNFRSF1B; SLC1A2; BCL2; APAF1; PPP3CB; CCS; GRIN2A
    Huntingtons disease UQCR10; HDAC2; NDUFB11; NDUFS1; TFAM; TBP; NDUFAB1; SLC25A5; HTT; NDUFB10
    Pertussis CASP7; C1QA; IRF3; TICAM2; RELA; CXCL5; GNAI1; IL12A; LY96; NFKB1
    Legionellosis IL6; HSPA8; VCP; NLRC4; PYCARD; RAB1B; CASP7; TNF; SAR1B; APAF1
    Toxoplasmosis TAB2; BIRC8; MAP3K7; BIRC7; HSPA2; STAT3; TRAF6; BCL2; LAMC2; IKBKG
    Amoebiasis LAMB4; COL27A1; PRKCG; FN1; ARG1; COL1A1; CD1D; C8A; PTK2; PRKACA
    Tuberculosis IFNA6; EP300; HLA-DRB3; TNF; HSPA9; IFNB1; HLA-DOA; CD209B; ATP6V1H; ATP6V0B
    Hepatitis B TLR3; Fasl; NFATC4; FADD; BIRC5; NRAS; IFNA14; MAP3K1; CCND1; CREB3L1
    Herpes simplex infection RELA; BMA1; EEF1D; TNF; POU2F3; PPP1CA; IFNA3; IFNA10; IL1B; HCFC2
    Pathways in cancer PIK3CB; MSH6; BIRC2; Pdgfa&Pdgfb; AGTR1B; STAT3; PGF; NFKB1; WNT4; RALGDS
    Viral carcinogenesis HIST1H2BE; DDX3X; HLA-F; HIST1H4A; HPN; MRPS18B; HIST1H2BC; RBL2; PIK3R2; PIK3R3
    Proteoglycans in cancer PDCD4; MRAS; IGF2; HSPB2; PRKACA; ITPR1; PPP1CC; Fasl; ANK2; HSPG2
    MicroRNAs in cancer HOXD10; ST14; ITGA5; BAK1; UBE2I; FSCN1; IKBKB; RDX; VIM; TIMP3
    Colorectal cancer APC; PIK3CD; PIK3R5; TRP53; RAF1; SMAD2; TP53; TGFBR2; AKT2; RALGDS
    Viral myocarditis CXADR; H2-AB1; ABL1; HLA-DMA; ABL2; BID; CASP9; ITGAL; RAC3; EIF4G2

    Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.

    Function Related Protein
    aspartic-type endopeptidase activity DDI1; SPPL2; ASPRV1; PGA4; REN; PSEN2; SPPL3; NRIP3; CTSD; DDI2
    cyclin-dependent protein serine/threonine kinase inhibitor activity CDKN1D; HEXIM2; CDKN1BA; CDKN1BB; CDKN2A; CDKN2C; CDKN1A; KAT2B; Casp3; CDKN1C
    cysteine-type endopeptidase activity CFLARA; MALT1A; LGMN; UCHL1; CTSB; CTSW; DUB1; USP10; USP19; USP49
    cysteine-type endopeptidase activity involved in apoptotic process CLC; CASP8; Casp3
    cysteine-type endopeptidase activity involved in execution phase of apoptosis CASP6L2; Casp3; CASP7; CASP6L1; CASP3B; CASP3A; CASP6
    cysteine-type peptidase activity CASP7; CASP3B; SENP3A; ZRANB1B; USP17L3; CTLA2B; CAPN2; USP2A; PIGK; CAPN3B
    death receptor binding FASLG; CFLAR; CASP8; FEM1B; TMBIM1; PIDD1; TNFSF15; RIPK1; Fasl; MYD88
    hydrolase activity GNPDA1; ENTPD7; ATP11A; MMP14B; UNGA; TIGARA; IDI1; AADACL4; BMP1B; TRY
    peptidase activity UCHL3; PM20D1; IWS1; APH1C; BMP1B; FAM49BA; USP27X; MCPT8; CTSLA; PROCA
    phospholipase A2 activator activity PLAA; Casp3
    protease binding TRP53; ADRM1; FLOT2; PYCARD; BRCA2; BCL10; F3; RYR1; NFRKB; SELL
    protein binding DIP2A; NRSN1; MUTYH; LRRFIP2; PFDN2; SOSTDC1B; TXNDC11; MC3R; PRAC; EPB41L3
    protein complex binding PTK2B; Casp3; NASP; FYB; GIT1; ANKRD32; ANKRD54; UFD1L; Cel; STRN

    Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.

    THAP11; Parp1; Hdgf; Pkm; Rps18; Acta2; Fam21; Nucks1; Htt

    Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).

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