casp2

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casp2

Official Full Name caspase 2, apoptosis-related cysteine peptidase
Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms Apoptosis related cysteine peptidase; CASP 2; Casp 2L Pro; CASP2; Caspase 2 apoptosis related cysteine protease; Caspase2; Developmentally down regulated 2; ICH 1; ICH 1 protease; ICH 1L; ICH 1L/1S; ICH1; ICH1 protease; ICH1L/1S; NEDD 2; NEDD2 apoptosis regulatory gene; Neural precursor cell expressed; Neural precursor cell expressed developmentally down regulated 2; OTTHUMP00000025259; OTTHUMP00000202227; neural precursor cell expressed developmentally down-regulated protein 2; EC 3.4.22.55; Protease ICH-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP2-0419H Recombinant Human CASP2 Protein, GST-Tagged Wheat Germ GST
    Human CASP2-10731H Recombinant Human CASP2, GST-tagged E.coli GST
    Human CASP2-195H Recombinant Human CASP2, His-tagged E.coli His
    Human CASP2-285HCL Recombinant Human CASP2 cell lysate N/A
    Human CASP2-296H Recombinant Human CASP2 Protein, His/GST-tagged E.coli His/GST
    Human CASP2-484H Recombinant Human CASP2 Mammalian Cell His
    Human CASP2-747H Recombinant Human Caspase 2, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP2-819H Recombinant Human CASP2 Protein, His-tagged E.coli His
    Mouse CASP2-2751M Recombinant Mouse CASP2 Protein Mammalian Cell His
    Mouse Casp2-297M Recombinant Mouse Casp2 Protein, His-tagged E.coli His
    Rat CASP2-1144R Recombinant Rat CASP2 Protein Mammalian Cell His
    Chicken CASP2-4013C Recombinant Chicken CASP2 Mammalian Cell His
    Zebrafish CASP2-3823Z Recombinant Zebrafish CASP2 Mammalian Cell His

    casp2 involved in several pathways and played different roles in them. We selected most pathways casp2 participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Apoptosis Modulation by HSP70, which may be useful for your reference. Also, other proteins which involved in the same pathway with casp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis CDKN2A; STK24; DSG2; MYC; CTNNB1; DBNLB; PPP3CCA; IKBKB; NFKBIA; PRKAR1B
    Apoptosis Modulation and Signaling DIABLO; SEPT4; BOK; CASP2; DAXX; CAPNS1; BLK; PTPN13; CDKN2A; CRADD
    Apoptosis Modulation by HSP70 DERL3; CASP2
    Caspase cascade in apoptosis PARP1; LMNB1; DFFA; CASP4; GAS2; CRADD; TOP1; DIABLO; CASP2; SATB1
    Cell death signalling via NRAGE, NRIF and NADE FGD2; MCF2L; ARHGAP4A; ARHGEF9; PLEKHG2; ITGB3BP; FGD4A; ARHGAP4; OBSCN; ARHGEF3
    HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD; DFFA; CASP2; DAXX
    Immune System RIPK3; WIPF3; FCGR1B; WWP1; NLRP4; KLRB1F; PANX1; KIF2B; KLHL20; TRIM8
    Innate Immune System DEFA6; CD180; DEFB119; DEFA3; PANX1B; TAX1BP1B; POLR3C; ACTR2B; TXNIPB; LAT2

    casp2 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by casp2 itself. We selected most functions casp2 had, and list some proteins which have the same functions with casp2. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity ATG4B; USP20; CTSO; USP3; DUB1; Ctsl; USP15; USP45; CTSH; USP14
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway CASP14; CASP8L1; CFLARA; CASP8; CASP10; CFLAR; CASP2; CASP9
    enzyme binding PARK2; LDB2; POLB; PDE4D; EHHADH; PLSCR4; TNKS2; PLCE1; Il6ra; CYP2E1
    protein binding SLC22A7; FOXM1; SGSM3; STK39; UGP2; BICC1; MYOC; C11orf68; TMEM149; PALM
    protein domain specific binding ARFIP1; FOXA2; HAND2; YWHAQB; ZNF521; ICA1L; ZFP521; CALM3; TNNI3; GSN

    casp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with casp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of casp2.

    CRADD; PIDD1; PRKDC

    Zhang, H; Sweezey, NB; et al. LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L391-L402(2015).
    Wilson, CH; Shalini, S; et al. Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. CELL DEATH & DISEASE 6:-(2015).

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