CASP1

  • Official Full Name

    Cas-Br-M (murine) ecotropic retroviral transforming sequence

  • Overview

    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
  • Synonyms

    CASP 1; CASP-1; CASP1; CASP1_HUMAN; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase-1 subunit p10; Caspase1; ICE; IL 1 beta converting enzyme; IL 1BC; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; IL1BC; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; P45; OTTHUMP00000045728; OTTHUMP00000232029; OTTHUMP00000232030; OTTHUMP00000232031; OTTHUMP00000232032; OTTHUMP00000232033; OTTHUMP00000232034; OTTHUMP00000232036;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • HA
  • GST
  • His
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP1-180H Recombinant Human CASP1 protein, His-tagged E.coli His 1-311
Human CASP1-596H Recombinant Human CASP1 E.coli Non
Human CASP1-1639H Recombinant Human Caspase 1, Apoptosis-Related Cysteine Peptidase (interleukin 1, beta, convertase), His-tagged E.coli His
Human CASP1-10729H Recombinant Human CASP1, GST-tagged E.coli GST 1-311a.a.
Human CASP1-173H Recombinant Human CASP1 Protein, His-tagged E.coli His
Human CASP1-174H Recombinant Human CASP1 Protein, His-tagged E.coli His
Human CASP1-0411H Recombinant Human CASP1 Protein, GST-Tagged Wheat Germ GST
Human CASP1-7841HCL Recombinant Human CASP1 293 Cell Lysate HEK293 Non
Human CASP1-7840HCL Recombinant Human CASP1 293 Cell Lysate HEK293 Non
Human CASP1-2634H Recombinant Human CASP1 protein, GST-tagged E.coli GST 120-269aa
Human CASP1-621H Recombinant Human CASP1 Protein, His-tagged E.coli His Asn120-His404
Human CASP1-3737H Recombinant Human CASP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Human CASP1-1588HFL Recombinant Full Length Human CASP1 Protein, N-His-tagged E.coli His
Human CASP1-2921HF Recombinant Full Length Human CASP1 Protein, GST-tagged In Vitro Cell Free System GST 311 amino acids
Human CASP1-432H Recombinant Human CASP1 protein, HA-tagged E.coli C-HA 1-91aa
Human CASP1-1265H Recombinant Human CASP1 Protein (N120-D297, A317-H404), Tag Free E.coli Non N120-D297, A317-H404
Human CASP1-1213H Recombinant Human CASP1 Protein (Asn120-Asp297), N-His tagged E.coli His Asn120-Asp297
Human CASP1-1266H Recombinant Human CASP1 Protein (N120-D297, A317-H404), His tagged E.coli His N120-D297, A317-H404
Mouse Casp1-0413M Active Recombinant Mouse Casp1 Protein E.coli Non
Mouse CASP1-2748M Recombinant Mouse CASP1 Protein Mammalian Cell His
Mouse Casp1-7151M Recombinant Mouse Casp1 protein, His-tagged E.coli His Asn119~Asp296
Mouse CASP1-1240M Recombinant Mouse CASP1 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse CASP1-1240M-B Recombinant Mouse CASP1 Protein Pre-coupled Magnetic Beads HEK293
Rat Casp1-577R Recombinant Rat Casp1 protein, His-tagged E.coli His Asn119~Asp296
Arabidopsis thaliana (Mouse-ear cress) RFL8659AF Recombinant Full Length Arabidopsis Thaliana Casparian Strip Membrane Protein 1(Casp1) Protein, His-Tagged E.coli expression system His Full Length (1-206)
Pig CASP1-7152P Recombinant Pig CASP1 protein, His-tagged E.coli His Asn120~Asp297
Pig CASP1-473P Recombinant Pig CASP1 protein, His&Myc-tagged E.coli His&Myc 120-297a.a.
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CASP1 involved in several pathways and played different roles in them. We selected most pathways CASP1 participated on our site, such as NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NOD-like receptor signaling pathwayMAPK8B;MAP3K7IP3;CXCL2;TRIP6;NFKBIAA;SUGT1;CXCL1;MAPK13;NLRP3
Cytosolic DNA-sensing pathwayPOLR3E;IFNA10;POLR3GLB;IFNA1;POLR3G;IKBKE;CCL4L1;IL33;Ifna15
Amyotrophic lateral sclerosis (ALS)ALS2;CAT;GRIN2C;GRIN2A;SLC1A2;TNFRSF1B;CCS;MAPK14;GPX1
Salmonella infectionWASF1;MAPK14B;CXCL3;CXCL8B.3;ARPC5LB;CCL3;PFN1;ROCK1;KLC1B
PertussisCASP7;IL1A;IL6;AMCF-II;C2;CALML3;Itgam&Itgb2;GNAI1;Hc
LegionellosisItgam&Itgb2;Casp3;EEF1A1;HBS1L;ITGAM;CXCL2;CYCS;NLRC4;NFKB1
Influenza ACASP1;BLA;MAPK13;PIK3R3;HSPA2;PLG;HLA-DOB;MYD88;OAS1A

CASP1 has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP1 itself. We selected most functions CASP1 had, and list some proteins which have the same functions with CASP1. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activator activity involved in apoptotic processBAD;BCL2L13;GNB2L1;CTSH;APAF1;PYCARD;NLRP12;CARD8;NOD1
cysteine-type endopeptidase activityCTSM;CASP3B;CTSS;USP6;USP43A;CASP9;CASP10;CASP6L1;USP45
NOT cysteine-type endopeptidase activity involved in execution phase of apoptosisCASPA;CASPB;PSD;CASP12;CASP4;CASPBL;CASP1;CASP5
endopeptidase activityF9;PSMB9A;PSMB9;ATG4B;PSEN1;CASP1;KLK1B26;CPS1;TMEM59
protein bindingSSTR3;RBP7;RNF220;KIAA1199;TLE1;PAGE5;SCMH1;WASF1;GLRX3

CASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP1.

NLRC4; PYCARD; VAC14; IL1A; AIM2; ATG16L1; RIPK2

Research Area

Related articles

He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).
Hoque, R; Farooq, A; et al. Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor- and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity. GASTROENTEROLOGY 146:1763-1774(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
09/14/2022

    Fast delivery, reliable results.

    01/21/2022

      Very high-quality product.

      07/28/2021

        Great for protein research.

        Q&As (7)

        Ask a question
        How does CASP1 contribute to the regulation of the inflammatory response? 08/06/2022

        It processes pro-inflammatory cytokines to their active forms, modulating inflammation.

        What therapeutic strategies are being explored targeting CASP1 for disease treatment? 02/13/2022

        Therapeutic strategies include CASP1 inhibitors, aiming to reduce inflammation in diseases like cryopyrin-associated periodic syndromes (CAPS).

        What role does CASP1 play in the maturation and secretion of pro-inflammatory cytokines? 06/07/2021

        It is essential for the maturation and secretion of IL-1β and IL-18, pro-inflammatory cytokines.

        In which cells or tissues is CASP1 predominantly expressed? 09/30/2019

        CASP1 is predominantly expressed in immune cells like macrophages and dendritic cells.

        Are there known genetic mutations in CASP1 associated with specific diseases? 09/09/2019

        Genetic mutations in CASP1 have been associated with increased susceptibility to certain infectious and inflammatory diseases.

        How is CASP1 implicated in the pathogenesis of autoinflammatory diseases? 04/03/2019

        Dysregulation of CASP1 is linked to autoinflammatory diseases, causing excessive inflammation.

        What is the primary biological function of CASP1 in cells? 07/26/2018

        CASP1 is a protease that plays a critical role in the initiation of apoptosis and inflammation.

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