casp4

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casp4

Official Full Name caspase 4, apoptosis-related cysteine peptidase
Background This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Synonyms Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP-4; CASP4; CASP4_HUMAN; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; OTTHUMP00000231863; OTTHUMP00000231864; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57; EC 3.4.22
    • Species :
    • Cattle
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP4-0424H Recombinant Human CASP4 Protein, GST-Tagged Wheat Germ GST
    Human CASP4-26607TH Recombinant Human CASP4 E.coli N/A
    Human CASP4-599H Recombinant Human Caspase 4, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP4-607H Recombinant Human CASP4 Mammalian Cell His
    Human CASP4-7836HCL Recombinant Human CASP4 293 Cell Lysate HEK293 N/A
    Human CASP4-7837HCL Recombinant Human CASP4 293 Cell Lysate HEK293 N/A
    Human CASP4-820H Recombinant Human CASP4 Protein, His-tagged E.coli His
    Mouse Casp4-1864M Recombinant Mouse Casp4 protein, His-tagged E.coli His
    Mouse CASP4-2753M Recombinant Mouse CASP4 Protein Mammalian Cell His
    Rhesus Macaque CASP4-634R Recombinant Rhesus monkey CASP4 Protein, His-tagged Mammalian Cell His
    Cattle CASP4-1861C Recombinant Cattle CASP4 protein, His-tagged E.coli His
    Cattle CASP4-1862C Recombinant Cattle CASP4 protein, His-tagged E.coli His

    casp4 involved in several pathways and played different roles in them. We selected most pathways casp4 participated on our site, such as Apoptosis, Caspase cascade in apoptosis, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with casp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis ADD1; PPP3CA; OCLN; VIML; TRADD; PRKACB; PRKAR2B; DNM1L; DIABLO; PPP3R1B
    Caspase cascade in apoptosis NUMA1; DIABLO; PARP1; CRADD; TFAP2A; GAS2; CASP2; DFFA; SATB1; TOP1
    Immune System MAP3K8; CD300LD; RACGAP1; TREX1; SIGIRR; RAPGEF4; SOCS3A; PJA2; AP1S1; LILRB1
    Innate Immune System ART1; ACTR2B; MAP3K8; POLR3H; CFHL2; TNIP2; DEFB103A; NCKIPSD; BTR06; ALCAMB
    NOD1/2 Signaling Pathway CASP4; CYLD
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways BTR12; PANX1; BTR16; PANX1B; TXNIPB; BTR29; NLRP3; BTR30; BTR22; TXNIP

    casp4 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by casp4 itself. We selected most functions casp4 had, and list some proteins which have the same functions with casp4. You can find most of the proteins on our site.

    Function Related Protein
    NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis CASP12; PSD; CASP5; CASPA; CASPB; CASP1; CASP4; CASPBL

    casp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with casp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of casp4.

    COPE; SNRNP200; UFL1; SMC2; GSN; SNRPA1; UMPS; PSMB1; VDAC1; CDK2; EIF2S3; SSR4; MSH6; SLC25A1; UBXN1; DCTN1; SMC1A; PSMD6; MTHFD1L

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