CASP5

  • Official Full Name

    caspase 5, apoptosis-related cysteine peptidase

  • Overview

    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
  • Synonyms

    Apoptosis related cysteine protease; apoptosis-related cysteine protease; CASP5; ICE(rel)III; ICERELIII; ICH 3; ICH 3 protease; ICH3; TY; TY Protease; caspase-5; CASP-5; OTTHUMP00000045729; OTTHUMP00000209889; OTTHUMP00000231914; OTTHUMP00000231915; caspase 5, apoptosis-related cysteine peptidase; MGC141966; EC 3.4.22.58; EC 3.4.22;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Human
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • Fc
  • Avi
  • SUMO
  • T7
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP5-32H Active Recombinant Human Caspase-5 Enzyme Non
Human CASP5-821H Recombinant Human CASP5 Protein, His-tagged E.coli His
Human CASP5-600H Recombinant Human Caspase 5, Apoptosis-related Cysteine Peptidase E.coli Non
Human CASP5-608H Recombinant Human CASP5 Mammalian Cell His
Human CASP5-7647H Recombinant Human CASP5 protein, His & T7-tagged E.coli His&T7 Pro145~Asp327
Human CASP5-10734H Recombinant Human CASP5, GST-tagged E.coli GST 1-418a.a.
Human CASP5-0425H Recombinant Human CASP5 Protein, GST-Tagged Wheat Germ GST
Human CASP5-7835HCL Recombinant Human CASP5 293 Cell Lysate HEK293 Non
Human CASP5-1348H Recombinant Human CASP5 Protein (137-327 aa), His-tagged Yeast His 137-327 aa
Human CASP5-2595H Recombinant Human CASP5 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human CASP5-01H Active Recombinant Human CASP5 Protein E.coli
Human CASP5-2637H Recombinant Human CASP5 protein, His-SUMO-tagged E.coli His&SUMO 137-327aa
Human CASP5-2595H-B Recombinant Human CASP5 Protein Pre-coupled Magnetic Beads HEK293
Human CASP5-0859H Recombinant Human CASP5 Protein (Pro145-Asp327), His tagged E.coli His Pro145-Asp327
Human CASP5-0860H Recombinant Human CASP5 Protein (Ile182-Asp327), N-His tagged E.coli His Ile182-Asp327
Arabidopsis thaliana (Mouse-ear cress) RFL14077AF Recombinant Full Length Arabidopsis Thaliana Casparian Strip Membrane Protein 5(Casp5) Protein, His-Tagged E.coli expression system His Full Length (1-187)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CASP5 involved in several pathways and played different roles in them. We selected most pathways CASP5 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NOD-like receptor signaling pathwayMAPK12;MAPK12A;NLRP1;MAPK8B;MAPK1;CASP1;NLRP3;IKBKG;HSP90AA1.1

CASP5 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP5 itself. We selected most functions CASP5 had, and list some proteins which have the same functions with CASP5. You can find most of the proteins on our site.

Function Related Protein
NOT cysteine-type endopeptidase activity involved in execution phase of apoptosisCASP4;CASP1;CASPA;CASPB;PSD;CASP12;CASP5;CASPBL
cysteine-type peptidase activityCTS7;CTSW;SENP7;CAPN2B;ESPL1;CAPN3A;ATG4A;CTSL1;DESI1

CASP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP5.

NLRP1

Research Area

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