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CASP6

  • Official Full Name

    caspase 6, apoptosis-related cysteine peptidase

  • Overview

    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms

    CASP6; caspase 6, apoptosis-related cysteine peptidase; MCH2; caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP6-298H Recombinant Human CASP6 Protein, His-tagged E.coli His
Human CASP6-26830TH Recombinant Human CASP6 N/A
Human CASP6-0426H Active Recombinant Human CASP6 Protein E.coli N/A
Human CASP6-601H Recombinant Human Caspase 6, Apoptosis-related Cysteine Peptidase E.coli N/A
Human CASP6-0427H Recombinant Human CASP6 Protein, GST-Tagged Wheat Germ GST
Human CASP6-10735H Recombinant Human CASP6 protein(59-222 aa), His-tagged E.coli His 59-222 aa
Human CASP6-7834HCL Recombinant Human CASP6 293 Cell Lysate HEK293 N/A
Human CASP6-0861H Recombinant Human CASP6 Protein (Ala194-Asn293), His tagged E.coli His Ala194-Asn293
Human CASP6-568H Recombinant Human CASP6 Protein, His-tagged E.coli His Ala194~Asn293
Human CASP6-2929HF Recombinant Full Length Human CASP6 Protein, GST-tagged In Vitro Cell Free System GST 293 amino acids
Mouse Casp6-16M Recombinant Mouse Casp6 protein, His-tagged E.coli His
Mouse CASP6-2754M Recombinant Mouse CASP6 Protein Mammalian Cell His
Mouse CASP6-1245M Recombinant Mouse CASP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CASP6-1245M-B Recombinant Mouse CASP6 Protein Pre-coupled Magnetic Beads HEK293
Bovine CASP6-566B Recombinant Bovine CASP6 Protein, His-tagged E.coli His Leu81~Asp179
Zebrafish CASP6-2695Z Recombinant Zebrafish CASP6 Mammalian Cell His
Chicken CASP6-6291C Recombinant Chicken CASP6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CASP6 Related Research Area

CASP6 involved in several pathways and played different roles in them. We selected most pathways CASP6 participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisCDK5RAP2;TRAF2;IRF1B;BOKA;HIST1H1B;Casp3;PRKAR2A;BCL2L1;DFFA

CASP6 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP6 itself. We selected most functions CASP6 had, and list some proteins which have the same functions with CASP6. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activityUSP3;MALT1;USP45;USP1;USP10;USP24;CASP8L1;CTSW;FMNL3
cysteine-type endopeptidase activity involved in execution phase of apoptosisCASP6L1;CASP3A;Casp3;CASP6;CASP3B;CASP6L2;CASP7
cysteine-type peptidase activityFAM105B;SENP3B;CTSW;Ctsl;ATG4A;USP9;CTSL1B;CTSM;CAPN1B
identical protein bindingTNF;SNX1;BIN1;MSANTD3;DRD2;CDC42;SHARPIN;BLOC1S6;PRDX1
protein bindingCXXC1;KRTAP5-9;INCA1;LBH;MAGEA3;ANKHD1;MANBAL;NGB;KRTAP10-9

CASP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP6.

act-veid; NUCB2; NUCB1; PARP10; ATG16L1; APP; CASP3; SATB1; PRKAB2; CHD3; PIN1; TAB1; MAPK6; IKBKG

  • Q&As
  • Reviews

Q&As (5)

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Are there any potential therapeutic applications of targeting CASP6 in Alzheimer's disease? 09/27/2021

Targeting CASP6 activity may offer a potential therapeutic strategy for slowing down the progression of Alzheimer's disease.

Can targeting CASP6 protein have applications beyond neurodegenerative diseases? 11/16/2019

There is potential for CASP6 to be targeted in other diseases involving aberrant cell death pathways, such as certain types of cancer and autoimmune diseases.

Are there any specific drugs that target CASP6 protein? 08/28/2019

Several research groups are working on developing small molecule inhibitors and other drugs that specifically target CASP6 for therapeutic purposes.

Are there any potential side effects of targeting CASP6 for therapeutic purposes? 04/25/2017

As with any targeted therapy, potential side effects and off-target effects of CASP6 inhibition or modulation need to be carefully evaluated in clinical trials.

What other diseases are being studied in relation to CASP6 protein? 04/02/2016

CASP6 is also being investigated in the context of other neurodegenerative disorders such as Parkinson's disease and amyotrophic lateral sclerosis (ALS).

Customer Reviews (3)

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Reviews
12/24/2022

    Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.

    12/13/2018

      The CASP6 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.

      02/12/2018

        Whether it's protein quantification, structural analysis, or Western Blotting, the CASP6 protein has consistently delivered exceptional results, earning my highest recommendation.

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