| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. |
| Source : |
E. coli |
| Species : |
Human |
| Bio-activity : |
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 40-200 ng/mL. |
| Molecular Mass : |
13 kDa |
| Product-Related Proteins : |
283-396 |
| Endotoxin : |
< 0.1 EU/μg of the protein as determined by the LAL method |
| Purity : |
> 95 % as determined by SDS-PAGE |
| Storage : |
At -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
PBS |
