Recombinant Human CDK1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CDK1-2157H
• Product Overview: CDK1 MS Standard C13 and N15-labeled recombinant protein (NP_001777) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 34.1 kDa
• AA Sequence: MEDYTKIEKIGEGTYGVVYKGRHKT TGQVVAMKKIRLESEEEGVPSTAIR EISLLKELRHPNIVSLQDVLMQDSR LYLIFEFLSMDLKKYLDSIPPGQYM DSSLVKSYLYQILQGIVFCHSRRVL HRDLKPQNLLIDDKGTIKLADFGLA RAFGIPIRVYTHEVVTLWYRSPEVL LGSARYSTPVDIWSIGTIFAELATK KPLFHGDSEIDQLFRIFRALGTPNN EVWPEVESLQDYKNTFPKWKPGSLA SHVKNLDENGLDLLSKMLIYDPAKR ISGKMALNHPYFNDLDNQIKKMTRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CDK1 cyclin-dependent kinase 1 [ Homo sapiens (human) ]
• Official Symbol: CDK1
• Synonyms: CDK1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222
• Gene ID: 983
• mRNA Refseq: NM_001786
• Protein Refseq: NP_001777
• MIM: 116940
• UniProt ID: P06493

Reviews

01/30/2023

The product brochure is very detailed and has comprehensive basic information about the CDK1 protein.

11/09/2022

The staff actively communicated with me and solved many technical problems.

10/18/2022

Very professional customer service, fully understanding the needs of the customer and giving professional advice.

Q&As

What diseases is CDK1 involved in?

CDK1 is involved in papillary thyroid cancer, hepatocellular carcinoma, and other diseases.

How does CDK1 relate to IL-33 expression?

CDK1 is positively correlated with IL⁃33 expression and CDK1 and IL⁃33 expression interact with each other.

What is the function of CDK1?

CDK1 is an important regulator of the eukaryotic cell cycle that drives cell cycle progression by binding to cell cycle proteins.

What is the expression level of CDK1 in colorectal cancer?

CDK1 expression levels were higher in CRC tissues than in paracancerous tissues.