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Official Full Name cyclin-dependent kinase 2
Background This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Synonyms CDK2; cyclin-dependent kinase 2; CDKN2; p33(CDK2); p33 protein kinase; cdc2-related protein kinase; cell division protein kinase 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK2/CyclinA2-272H Recombinant Human CDK2/Cyclin A2, GST-tagged, Active Sf9 Insect Cell GST
    Human CDK2-1000H Recombinant Human CDK2 Protein, GST-Tagged Wheat Germ GST
    Human CDK2-1003H Recombinant Human CDK2 Protein, GST-Tagged Insect Cell GST
    Human CDK2-114H Recombinant Human CDK2/CyclinO, GST-tagged Sf9 Insect Cell GST
    Human CDK2-172H Recombinant Human CDK2 Mammalian Cell His
    Human CDK2-1933H Recombinant Human CDK2 protein, His & GST-tagged E.coli His/GST
    Human CDK2-30287TH Recombinant Human Human CCNE1 N/A
    Human CDK2-3142H Recombinant Human CDK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CDK2-31594TH Recombinant Human Human CDK2 Sf9 Insect Cell N/A
    Human CDK2-48H Recombinant Human CDK2/CCNE1 protein, GST-tagged Insect Cell GST
    Human CDK2-5392H Recombinant Human CDK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDK2-615H Recombinant Human CDK2, His tagged Insect Cell His
    Human CDK2-655H Recombinant Human cyclin-dependent kinase 2, His-tagged Insect Cell His
    Human CDK2-708HCL Recombinant Human CDK2 cell lysate Insect Cell N/A
    Human CDK2-797H Recombinant Human CDK2, His-tagged Human His
    Human CDK2-999H Recombinant Human Cyclin-Dependent Kinase 2, GST-tagged Sf9 Insect Cell GST
    Mouse Cdk2-1934M Recombinant Mouse Cdk2 protein, His-tagged E.coli His
    Mouse Cdk2-1935M Recombinant Mouse Cdk2 protein, His & GST-tagged E.coli His/GST
    Mouse Cdk2-1936M Recombinant Mouse Cdk2 protein, His & MBP-tagged E.coli His/MBP
    Mouse CDK2-3199M Recombinant Mouse CDK2 Protein Mammalian Cell His
    Mouse Cdk2-864M Recombinant Mouse Cdk2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Cdk2-1937R Recombinant Rat Cdk2 protein, His-tagged E.coli His
    Rat Cdk2-1938R Recombinant Rat Cdk2 protein, His & GST-tagged E.coli His/GST
    Chicken CDK2-4480C Recombinant Chicken CDK2 Mammalian Cell His
    Zebrafish CDK2-12580Z Recombinant Zebrafish CDK2 Mammalian Cell His

    cdk2 involved in several pathways and played different roles in them. We selected most pathways cdk2 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdk2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    APC/C-mediated degradation of cell cycle proteins PSMD10; ANAPC10; CDK2; PSMD9; PSMD5; PSME3; UBE2C; PSMD14; PSMA8; NEK2
    Activation of ATR in response to replication stress MCM10; RAD9; CDK2; RAD17; CHEK1; RAD9A; HUS1; RAD9B; CLSPN; DBF4
    Activation of the pre-replicative complex MCM8; CDT1; DBF4; CDK2; MCM10
    B Cell Receptor Signaling Pathway PPP3R2; MALT1; VAV1; PIK3R1; CD72; CDK4; CD19; RAF1; CRK; PDK2B
    BARD1 signaling events RAD50; CSTF1; NPM1; RBBP8; BARD1; CDK2
    CDK-mediated phosphorylation and removal of Cdc6 CDK2
    Cell Cycle MCM4; BRCC3; SKP1; SPDL1; HDAC6; CDC14AB; MAD2L2; PDS5A; MYCB; SPO11
    Cell Cycle Checkpoints RAD17; CDK5RAP2; BRCC3; KAT5; HUS1; BARD1; RAD9A; HIST4H4; MCM10; RAD9B

    cdk2 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cdk2 itself. We selected most functions cdk2 had, and list some proteins which have the same functions with cdk2. You can find most of the proteins on our site.

    Function Related Protein
    cyclin binding CDKN1A; HDAC3; PTCH1; CUL3; INCA1; CDK13; CDK2; FBXW7; CDK6; CDK14
    cyclin-dependent protein serine/threonine kinase activity CDKL5; ICK; CCND3; CDK18; CDK13; CDK12; CDK5R1; CDKL4; CDK6; PFTK1
    contributes_to histone kinase activity CDK2
    metal ion binding ZNF354A; GNAZ; PVALB9; MOBKL2A; MZF1; PPM1AB; JADE1; LIMS2; CRBN; RPAIN
    protein binding PLIN3; PAIP1; B9D2; SDCCAG8; RNF139; SCRN2; SMARCA2; OSTF1; TF; WARS
    protein complex binding DAG1; YWHAB; SREBF1; RANBP2; PPP2R2A; VPS28; EPCAM; LCK; LAMB3; RAP1A

    cdk2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdk2 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdk2.


    Shi, HL; Fu, CL; et al. The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:2061-2070(2014).
    Wang, B; Li, DP; et al. Ionizing Radiation-Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 90:53-62(2014).

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