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CDK5RAP2

Official Full Name

CDK5 regulatory subunit associated protein 2
Overview

CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly.
Synonyms

CDK5RAP2; CDK5 regulatory subunit associated protein 2; MCPH3, microcephaly, primary autosomal recessive 3; CDK5 regulatory subunit-associated protein 2; C48; CEP215; FLJ10867; centrosomal protein 215 kDa; centrosome-associated protein 215; CDK5 activator-binding protein C48; MCPH3; KIAA1633; DKFZp686B1070; DKFZp686D1070;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	CDK5RAP2-3208M	Recombinant Mouse CDK5RAP2 Protein	Mammalian Cell	His	Inquiry
Mouse	CDK5RAP2-1529M-B	Recombinant Mouse CDK5RAP2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	CDK5RAP2-1529M	Recombinant Mouse CDK5RAP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein

CDK5RAP2 involved in several pathways and played different roles in them. We selected most pathways CDK5RAP2 participated on our site, such as Activation of BAD and translocation to mitochondria, Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5RAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activation of BAD and translocation to mitochondria	CDK5RAP2;YWHAQ;AKT3
Activation of BH3-only proteins	YWHAQ;DYNLL2;CDK5RAP2;E2F1;BCL2L11;AKT3
Anchoring of the basal body to the plasma membrane	CETN2;PCM1;TTBK2;FGFR1OP;AKAP9;TUBG1;ODF2;NDE1;NPHP1
Apoptosis	CDKN2A;IRAK2;PTBP3;PRKAR2AB;DFFB;CASP7;BAXA;CYCSB;MAP3K14
Assembly of the primary cilium	LZTFL1;TCTN3;CENPJ;IFT122;CEP89;MAPRE1;CEP97;IFT81;HSPB11
Cell Cycle	MCPH1;PMF1;NCAPH2;DCTN3;TERF2;HIST2H3C;CUL1A;ORC2;POLD3
Cell Cycle Checkpoints	DBF4;RAD9B;BRE;RAD9A;RNF168;RAD1;HTATIP;YWHAQ;HUS1
Cell Cycle, Mitotic	VRK1;RBBP4;STIL;AURKB;MYBL2;RANGAP1B;CP110;DULLARD;LIN37

CDK5RAP2 has several biochemical functions, for example, calmodulin binding, microtubule binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5RAP2 itself. We selected most functions CDK5RAP2 had, and list some proteins which have the same functions with CDK5RAP2. You can find most of the proteins on our site.

Function	Related Protein
calmodulin binding	ORAI1;CAMK2D1;MARCKSL1B;PDE1A;STRN4;MARCKSL1A;EPB41;MYH11;SNTA1
microtubule binding	DPYSL5A;KIF3A;GAS2L1;FES;MTAP4;CEP57;ARHGEF2;REEP1;KIF9
protein complex binding	PFKP;UFD1L;FBN1;LCK;GNB1;PAFAH1B1;TXN2;RXRA;ADM2
protein kinase binding	PRDX3;LAX1;SHC3;BCL10;MAPK6;MAP3K1;CALM2;ZC3HC1;NBEA
transcription regulatory region DNA binding	CREB3L1;ZNF821;LEF1;TBX21;CARM1;PAX8;ARID5A;TFE3;ETV5
tubulin binding	LRRK2;STMN4;TPPP3;DAG1;KIF14;ALDOA;STMN2A;CDK5RAP2;BIRC5

CDK5RAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5RAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5RAP2.

TBC1D31; PCM1; PDE4DIP; SEC16A; SIPA1L3; PCNT; PRKAR2A; PRKACA; PRKACB; DYNLL1; PCM1; KIAA0753; CEP170; MIB1; AKAP9; MYO10; CEP72; RRBP1; PGAP2; CEP131