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Official Full Name cyclin-dependent kinase 7
Background The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Synonyms CAK1; MO15; STK1; CDKN7; p39MO15; CDK7; cyclin-dependent kinase 7; CAK; p39 Mo15; 39 KDa protein kinase; Cdk-activating kinase; kinase subunit of CAK; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cdk7-868M Recombinant Mouse Cdk7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CDK7 & CCNH & MNAT1-539HCL Recombinant Human CDK7 & CCNH & MNAT1 cell lysate Insect Cell N/A
    Human CDK7/CCNH/MNAT1-279H Recombinant Human CDK7/CCNH/MNAT1, His-tagged, Active Sf9 Insect Cell His
    Human CDK7-1033H Recombinant Human CDK7 Protein, GST-Tagged Wheat Germ GST
    Human CDK7-1035H Recombinant Human CDK7 Protein, GST-His-Tagged Insect Cell GST/His
    Human CDK7-1036H Recombinant Human CDK7 Protein, GST-Tagged Insect Cell GST
    Human CDK7-1151H Recombinant Human Cyclin-Dependent Kinase 7, His-tagged Human His
    Human CDK7-1539H Recombinant Human CDK7, Unactive, GST-tagged Sf9 Insect Cell GST
    Human CDK7-31757TH Recombinant Human Human CDK7, His-tagged His
    Human CDK7-568H Recombinant Human CDK7 Mammalian Cell His
    Human CDK7-7621HCL Recombinant Human CDK7 293 Cell Lysate HEK293 N/A
    Mouse Cdk7-1925M Recombinant Mouse Cdk7 protein, His-tagged E.coli His
    Mouse CDK7-3211M Recombinant Mouse CDK7 Protein Mammalian Cell His
    Rhesus Macaque CDK7-789R Recombinant Rhesus monkey CDK7 Protein, His-tagged Mammalian Cell His
    Zebrafish CDK7-12210Z Recombinant Zebrafish CDK7 Mammalian Cell His

    cdk7 involved in several pathways and played different roles in them. We selected most pathways cdk7 participated on our site, such as B Cell Receptor Signaling Pathway, Basal transcription factors, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdk7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway CDK6; ARPC5; LAT2; PDPK1A; PDK2B; FCGR2B; LIME1; DAPP1; VAV1; STAP1
    Basal transcription factors GTF2F2A; MNAT1; TAF13; TAF9B; CDK7; GTF2H2; TBPL1; GTF2B; GTF2H3-2; TAF5
    Cell Cycle, Mitotic NCAPD2; CEP164; CSNK2A1; SPC25; DULLARD; NUP35; NIPBLB; ENSA; NUF2; TUBG1
    Cyclin A/B1 associated events during G2/M transition CDK7; FOXM1
    Cyclin A:Cdk2-associated events at S phase entry CKS1B; CDK7; MYCA
    Cyclin D associated events in G1 CDKN2C; E2F4; CDKN2D; CDK7; PIANP; CKS1B; CDKN2B

    cdk7 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cdk7 itself. We selected most functions cdk7 had, and list some proteins which have the same functions with cdk7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding P2RX6; LYN; UBE2B; OBSCN; SMC5; PINK1; DDX10; ABCG2D; MYH3; GRK7
    DNA-dependent ATPase activity RAD51C; MSH6; DHX36; CHD6; DDX11; MSH4; TOP2A; SMARCA2; IGHMBP2; ERCC6
    RNA polymerase II carboxy-terminal domain kinase activity CDK13; CDK8; CDK12; MAPK1; CCNK; CDK9; CDK7; CDK1
    androgen receptor binding NCOA3; TGFB1I1; CCNE1; WIPI1; PKN1; NSD1; CALR; KDM4C; PRMT2; FHL2
    cyclin-dependent protein serine/threonine kinase activity CDKL1; CDK5; MOK; CDK19; CDK17; CDK11A; ICK; CDK6; CDKL5; CDK9
    protein C-terminus binding DAB2; VAMP2; PDZD11; DBNL; PLEKHB1; FIGN; SIRT1; NEFL; SIAH1A; BCAM
    protein binding LONP1; PDZD3; GYPC; LCMT1; MIER1; DHX30; KIF23; NUTF2; DCAF7; TP53BP1
    protein kinase activity NPR2; CSNK1D; FASTKD2; PKMYT1; CSNK1DB; MAP2K5; STK24B; EGFRA; IGF1RB; INSRB
    transcription coactivator activity NR1H3; CRSP7; GATA3; CALCOCO1; HAND1; GABPA; KAT6A; E4F1; TFDP1; RBPMS

    cdk7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdk7 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdk7.

    CCNH; MNAT1; GTF2H5; Dlg4; SRPK2; SRPK1; HSP90AB1; E2F1; HLA-DQA1

    Caro-Astorga, J; Fajardo, I; et al. Nascent histamine induces alpha-synuclein and caspase-3 on human cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:580-586(2014).
    Phinyo, M; Nounurai, P; et al. Characterization and expression analysis of Cyclin-dependent kinase 7 gene and protein in ovaries of the giant tiger shrimp Penaeus monodon. AQUACULTURE 432:286-294(2014).

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