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Official Full Name cyclin-dependent kinase 9
Background The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
Synonyms CDK9; cyclin-dependent kinase 9; TAK; C-2k; CTK1; CDC2L4; PITALRE; CDC2-related kinase; cell division protein kinase 9; serine/threonine protein kinase PITALRE; cell division cycle 2-like protein kinase 4; tat-associated kinase complex catalytic subunit;
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His&GST
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK9-1042H Recombinant Human CDK9/CycT1 Complex Protein, His/GST-tagged Insect cell His&GST
    Human CDK9-1040H Recombinant Human CDK9 Protein, GST-Tagged Wheat Germ GST
    Human CDK9-178HCL Recombinant Human CDK9 lysate HEK293 N/A
    Human CDK9-2705H Recombinant Human CDK9 protein, His & T7-tagged E.coli His/T7
    Human CDK9-27909TH Recombinant Human CDK9 Unactive protein, GST-tagged Insect Cell GST
    Human CDK9-280H Recombinant Human Cyclin-Dependent Kinase 9, GST-tagged, Active Sf9 Insect Cell GST
    Rat CDK9-1309R Recombinant Rat CDK9 Protein Mammalian Cell His
    Rhesus Macaque CDK9-791R Recombinant Rhesus monkey CDK9 Protein, His-tagged Mammalian Cell His
    Chicken CDK9-1350C Recombinant Chicken CDK9 Mammalian Cell His
    Zebrafish CDK9-11870Z Recombinant Zebrafish CDK9 Mammalian Cell His

    cdk9 involved in several pathways and played different roles in them. We selected most pathways cdk9 participated on our site, such as Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdk9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Disease CDC37; KPNA4; RBP4; CCDC167; MIB1; OPN1SW; PSIP1; CDK9; TTR; AP1S1
    Formation of HIV elongation complex in the absence of HIV Tat WHSC2; SUPT5H; CTDP1; CDK9; SSRP1; ELL; COBRA1; TH1L; RDBP; TCEA1
    Formation of HIV-1 elongation complex containing HIV-1 Tat TCEA1; SUPT5H; CTDP1; TH1L; SSRP1; CDK9; ELL; WHSC2; TCEB3; RDBP
    Formation of RNA Pol II elongation complex TH1L; SUPT4H1; CCNT2A; COBRA1; CTDP1; CDK9; SSRP1A; TCEA1; WHSC2; NELFE
    Gene Expression TYW5; TNRC6B; HNRNPA2B1; TET2; ZNF554; ZFP473; NR5A1B; SKIB; AARS; ZNF70
    Generic Transcription Pathway SKIB; ZNF334; ZNF705A; TXN; ZNF554; ZNF256; MED23; ZNF19; ZKSCAN3; ZNF383
    HIV Life Cycle NMT2; TCEB3; PSIP1; TAF1L; RCC1; PDCD6IP; CDK9; ELL; NMT1; VPS37A

    cdk9 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cdk9 itself. We selected most functions cdk9 had, and list some proteins which have the same functions with cdk9. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding Fert2; P2RX1; NEK4; ATP2A1L; OASL2; CDK8; GRK1; NME1; ABCA6; ATP13A
    RNA polymerase II carboxy-terminal domain kinase activity CDK8; CDK12; CCNK; CDK9; CDK1; MAPK1; CDK7; CDK13
    chromatin binding NR5A1A; CBX4; PHC1; SMARCC1; NOC2L; KAT2A; HDGFRP2; YBX2; COQ7; UBTFL
    cyclin-dependent protein serine/threonine kinase activity CDK3; CDK16; CDK10; CCND3; CDKL4; CDK7; CDK11A; CDKL3; CDK9; CCNK
    protein binding TRAFD1; ZWINT; DHX32; NRP1; WDFY3; SENP7; HMBOX1; SCLY; MARCKSL1; UBLCP1
    protein kinase activity PIK3CG; MAP4K5; DAPK1; BMPR1AB; PRKG1A; FGFR1A; ROCK2A; TBK1; PAK4; CAMK2D2
    snRNA binding CCNT1; CDK9; RBPMS; HEXIM1; NCBP2; SNRNP35; HEXIM2
    transcription factor binding GATA3; PITX2; HDAC1; DR1; HDAC8; BRD7; AHR; SIRT2; JUNB; NFIA
    transcription regulatory region DNA binding RREB1; DLX5; TP53; SALL1; XRCC6; MSX2; SALL3B; FOXA3; TAL1; SMAD7

    cdk9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdk9 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdk9.

    CCNT1; AFF1

    Holcakova, J; Muller, P; et al. Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy. PLOS ONE 9:-(2014).
    Mbonye, UR; Gokulrangan, G; et al. Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes. PLOS PATHOGENS 9:-(2013).

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