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CDK1

  • Official Full Name

    cyclin-dependent kinase 1

  • Overview

    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; cyclin-dependent kinase 1; OTTHUMP00000019659; OTTHUMP00000019660; OTTHUMP00000223862; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cdk1-a; cyclin-dependent kinase 1-A; Cdc 2; CDK 1; CDK1; CDK1_HUMAN; Cell division control protein 2; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; p34 Cdk1; p34 protein kinase 1; cell division cycle 2 like; cell division protein kinase 1-A; cell division control protein 2-A; Cell division control protein 2 homolog 1; cdc-2; xcdc2; cdc2-a;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DDK
  • Fc
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDK1-3330H Recombinant Human CDK1, GST tagged Insect Cell GST Met 1-Met 297
Human CDK1-26954TH Recombinant Human CDK1 N/A
Human CDK1-171H Recombinant Human CDK1 Mammalian Cell His
Human CDK1/CyclinA2-271H Recombinant Human CDK1/Cyclin A2, GST-tagged, Active Sf9 Insect Cell GST
Human CDK1-2660H Recombinant Human CDK1, GST-His Sf9 Insect Cell His/GST
Human CDK1-31590TH Recombinant Human Human CDK1 Sf9 Insect Cell N/A
Human CDK1-654H Recombinant Human cyclin-dependent kinase 1, His-tagged Insect Cell His
Human CDK1-213H Recombinant Human CDK1 protein, T7/His-tagged E.coli T7/His
Human CDK1-997H Recombinant Human CDK1, GST-tagged E.coli GST True
Human CDK1-1533H Recombinant Human CDK1, Unactive, GST-tagged Sf9 Insect Cell GST Full length
Human CDK1-998H Recombinant Human Cyclin-Dependent Kinase 1, GST-tagged Sf9 Insect Cell GST
Human CDK1-31592TH Recombinant Human Human CDK1 Sf9 Insect Cell N/A
Human CDK1/CyclinB1-48H Recombinant Human CDK1/CyclinB1, GST-tagged, Active Insect Cell GST
Human CDK1-670HCL Recombinant Human CDK1 cell lysate Insect Cell N/A
Human CDK1-620HFL Recombinant Full Length Human CDK1 Protein, C-Flag-tagged Mammalian cells Flag
Human CDK1-9706HF Active Recombinant Full Length Human CDK1 Protein, GST-tagged Insect (sf21) GST 1-297(end)
Human CDK1-3143H Recombinant Human CDK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CDK1-2157H Recombinant Human CDK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDK1-653H Recombinant Human CDK1 protein, His-tagged E.coli His 1-297 aa
Human CDK1-2418HF Active Recombinant Full Length Human CDK1 Protein, GST-tagged Insect (sf21) GST 1-297
Human CDK1-3397HF Active Recombinant Full Length Human CDK1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-297(end)
Human CDK1-561H Recombinant Human CDK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDK1-4155HF Active Recombinant Full Length Human CDK1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-297(end)
Human CDK1-561H-B Recombinant Human CDK1 Protein Pre-coupled Magnetic Beads HEK293
Human CDK1-1071H Recombinant Human CDK1 Protein (Met1-Met297), His tagged E.coli His Met1-Met297
Mouse CDK1-402M Recombinant Mouse Cdk1, His-GST tagged Insect Cell Fc
Mouse Cdk1-1932M Recombinant Mouse Cdk1 protein, His-tagged E.coli His Gly13~Met297 (Accession # P11440)
Mouse CDK1-001MCL Recombinant Mouse CDK1 cell lysate Insect Cell N/A
Mouse Cdk1-854M Recombinant Mouse Cdk1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CDK1-2211M Recombinant Mouse CDK1 protein, His&GST-tagged Insect Cells His/GST Met1-Met297
Rat CDK1-1299R Recombinant Rat CDK1 Protein Mammalian Cell His
Rat CDK1-957R Recombinant Rat CDK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CDK1-957R-B Recombinant Rat CDK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDK1-779R Recombinant Rhesus monkey CDK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDK1-605R-B Recombinant Rhesus Macaque CDK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDK1-605R Recombinant Rhesus Macaque CDK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDK1-11844Z Recombinant Zebrafish CDK1 Mammalian Cell His
Chicken CDK1-6866C Recombinant Chicken CDK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDK1 Related Articles
  • CDK1 Related Research Area
  • CDK1 Related Signal Pathway

CDK1 involved in several pathways and played different roles in them. We selected most pathways CDK1 participated on our site, such as Cell cycle, Oocyte meiosis, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleANKLE2;CENPE;SKA2;NCAPG;LEMD3;MCM7;MLF1IP;CSNK2B;CETN2
Oocyte meiosisPRKACBA;RPS6KAL;PRKACBB;YWHAG;PPP3CC;CALM2B;CALML3;CCNB1;CALM
p signaling pathwayAPAF1;ATM;CCNB2;CCND2;GADD45AA;SIAH2L;IGF1;BBC3;PPM1DA
Gap junctionDRD1B;PRKCBA;MAP3K2;TUBA4L;GNAQ;MAP2K1;GRB2;GNA11A;HTR2C
Progesterone-mediated oocyte maturationMAPK1;CCNB1;GNAI2B;MAPK3;PRKACB;Adcy4;RPS6KA2;CDC16;AKT1
Herpes simplex infectionEEF1DB;CCL2;TAF5;MAVS;TLR2;ARNTL1A;SRSF3;C3A.2;FOS
Epstein-Barr virus infectionPIK3R3;NFKBIA;TRAF3;POLR3D;MAP2K7;HSPA2;SYK;POLR2A;CD38
Viral carcinogenesisHDAC10;PRKACG;HIST1H4L;SRC;HIST1H2BF;RELA;ATF4;SCRIB;KAT2A

CDK1 has several biochemical functions, for example, ATP binding, Hsp70 protein binding, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK1 itself. We selected most functions CDK1 had, and list some proteins which have the same functions with CDK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP8B1;RPS6KAL;MAT1A;NPR2;FLT4;SLC14A2;STK35;ABL2;ACTR2B
Hsp70 protein bindingPARK2;TSACC;BAG6;RNF207;ST13;DNAJC2;STUB1;L7RN6;TFRC
RNA polymerase II carboxy-terminal domain kinase activityCCNK;CDK8;CDK7;CDK12;CDK1;CDK9;CDK13;MAPK1
cyclin-dependent protein serine/threonine kinase activityCDKL4;CDK8;CDK9;CDK5;CDK11A;CDK10;CDK14;CDK18;PFTK1
histone kinase activityCDK1;CCNB1;BAZ1B
protein bindingANKS1A;ATP2B1;ZNF143;CCT8;STK16;MIB1;RRAGB;GTF2E2;LSM5
protein kinase activityPRKG2;CSNK1G2A;NPR1A;STK24;IKBKAP;CLK4B;PKDCCA;MKNK2A;MAPK8A
protein serine/threonine kinase activityDAPK1;MAPK14;STK32B;PRKCE;STK38;CDK1;SIK2A;VPRBP;CAMK2D1

CDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK1.

CCNB1; CKS1B; PKMYT1

Zhu, BT; Xiahou, ZK; et al. MTHFR promotes heterochromatin maintenance. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447:702-706(2014).
Matthess, Y; Raab, M; et al. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. MOLECULAR ONCOLOGY 8:596-608(2014).
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