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CDK8

  • Official Full Name

    cyclin-dependent kinase 8

  • Overview

    The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members;are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are;known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are;components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the;largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the;CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the;Mediator-like protein complexes and the basal transcription machinery.
  • Synonyms

    CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDK8/CCNC-256H Active Recombinant Human CDK8/CCNC, GST&His-tagged Sf9 Insect Cell GST/His
Human CDK8-1038H Active Recombinant Human CDK8 Protein, GST-Tagged Insect Cell GST
Human CDK8-08H Recombinant Human CDK8, His-tagged E.coli N/A
Human CDK8-11H Recombinant Human CDK8, GST-tagged Wheat Germ GST
Human CDK8-1003H Recombinant Human Cyclin-Dependent Kinase 8, GST-tagged Sf9 Insect Cell GST
Human CDK8-1039H Active Recombinant Human CDK8 Protein, His-Tagged Insect Cell His
Human CDK8-10H Recombinant Human CDK8, MYC/DDK-tagged HEK293 Myc/DDK
Human CDK8-7620HCL Recombinant Human CDK8 293 Cell Lysate HEK293 N/A
Human CDK8-2151HF Active Recombinant Full Length Human CDK8 Protein, GST-tagged Insect (sf21) GST 1-464(end)
Human CDK8-1272H Recombinant Human CDK8 Protein (Glu21-Asp392), N-His tagged E.coli N-His Glu21-Asp392
Human CDK8-2923HF Active Recombinant Full Length Human CDK8 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-464(end)
Human CDK8-1603HFL Recombinant Full Length Human CDK8, Flag-tagged Mamanlian cells Flag
Human CDK8-6878HF Recombinant Full Length Human CDK8 Protein, GST-tagged In Vitro Cell Free System GST 464 amino acids
Mouse CDK8-3212M Recombinant Mouse CDK8 Protein Mammalian Cell His
Mouse Cdk8-2091M Recombinant Mouse Cdk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CDK8-1531M Recombinant Mouse CDK8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDK8-1531M-B Recombinant Mouse CDK8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDK8-790R Recombinant Rhesus monkey CDK8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDK8-616R-B Recombinant Rhesus Macaque CDK8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDK8-616R Recombinant Rhesus Macaque CDK8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDK8-9758Z Recombinant Zebrafish CDK8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDK8 Related Articles
  • CDK8 Related Research Area
  • CDK8 Related Signal Pathway

CDK8 involved in several pathways and played different roles in them. We selected most pathways CDK8 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsHEYL;CDK8;ADAM10;CCNC;JAG2;HEY1;JAG1;HDAC5;MIB1
Constitutive Signaling by NOTCH1 PEST Domain MutantsHDAC5;HEY2;HDAC6;ADAM10;JAG1;JAG2;CDK8;HEY1;CCNC
Developmental BiologyHELZ2;EFNB1;KIF4A;CNKSR1;LGI4;CAP1;COL4A3;PLXNC1;MED6
DiseaseKPNA5;FDX1L;MMADHC;SSRP1;TH1L;KREMEN1;OPN1MW;OS9;OPN1LW
Diseases of signal transductionMIB1;TNKS2;CUX1;JAG1;JAG2;RLBP1;RBP4;DERL2;HEY2
Fatty acid, triacylglycerol, and ketone body metabolismPLIN2;PPARGC1B;MED23;CTGF;ACAD11;MMAA;DGAT1B;ACOT12;CPT2
Gene ExpressionSF3B4;ZNF692;TET3;ZNF689;NR1H3;LSM11;GTF3A;CLNS1A;TRMT1
Generic Transcription PathwayZNF74;ZNF324;ZNF624;ZNF383;RNF111;ZNF167;JUNB;ZNF354A;ZNF253

CDK8 has several biochemical functions, for example, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK8 itself. We selected most functions CDK8 had, and list some proteins which have the same functions with CDK8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCHD7;WEE2;NAGK;MAP2K2A;ACVR1BA;TNK2;MAT1A;ACTR3;NADK2
RNA polymerase II carboxy-terminal domain kinase activityCDK1;CDK9;CDK7;CCNK;MAPK1;CDK12;CDK8;CDK13
cyclin-dependent protein serine/threonine kinase activityCDK5R1;STK30;MAK;CDK11A;CDK16;NAT1;CDKL3;CDK14;CDK18
protein bindingTAF9B;CCNB3;LIMK1;SNRPN;TPD52L1;RBMS1;NUDT2;KIF13B;IL33
protein kinase activityMAP3K4;CDK9;RAF1B;PTK7A;AKT3;IRAK1;RIPK3;PRKDC;PLK5
ubiquitin protein ligase activityMED21;TRIM2;SYVN1;ARIH1;UBE2KA;HLTF;RNF2;RNF217;CBLC

CDK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK8.

CCNC

Qu, XL; Li, XL; et al. Regulation of Renal Fibrosis by Smad3 Thr388 Phosphorylation. AMERICAN JOURNAL OF PATHOLOGY 184:944-952(2014).
Rovnak, J; Quackenbush, SL; et al. Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme. JOURNAL OF VIROLOGY 76:8031-8039(2002).
  • Q&As
  • Reviews

Q&As (5)

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Is CDK8 exclusively associated with cancer, or does it have physiological roles in normal cellular functions? 01/31/2020

CDK8 plays essential roles in normal cellular functions, including development and tissue homeostasis. Its dysregulation, however, is implicated in cancer.

Can CDK8 inhibitors be used in combination with other cancer treatments, and if so, what are the potential benefits? 11/07/2019

Combination therapies involving CDK8 inhibitors are being explored to enhance treatment outcomes and reduce the likelihood of resistance, providing a more comprehensive approach to cancer management.

How does CDK8 inhibition affect the cell cycle, and why is this significant in cancer therapy? 12/30/2018

CDK8 inhibition can disrupt the cell cycle, slowing down or halting the uncontrolled cell division characteristic of cancer cells, making it a potential therapeutic strategy.

How does CDK8 influence the immune response in the tumor microenvironment? 07/21/2017

CDK8 can modulate the expression of genes involved in immune response. Understanding its role in the tumor microenvironment may lead to novel immunotherapeutic strategies.

Are there ongoing clinical trials investigating the efficacy of CDK8 inhibitors in cancer patients? 06/11/2016

Yes, several clinical trials are underway to assess the safety and effectiveness of CDK8 inhibitors as a targeted therapy for different types of cancer.

Customer Reviews (3)

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Reviews
03/05/2020

    The CDK8 protein stands as a remarkable solution that exemplifies exceptional quality and meets all my experimental requirements.

    08/03/2019

      I am confident that the CDK8 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.

      10/01/2017

        Its impressive purity and functional characteristics make it an ideal choice for my research endeavors, ensuring reliable and impactful results.

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