CDK8
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Official Full Name
cyclin-dependent kinase 8
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Overview
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members;are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are;known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are;components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the;largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the;CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the;Mediator-like protein complexes and the basal transcription machinery. -
Synonyms
CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- GST|His
- His
- His (Fc)
- Avi
- Myc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CDK8 Related Articles
- CDK8 Related Research Area
- CDK8 Related Signal Pathway
CDK8 involved in several pathways and played different roles in them. We selected most pathways CDK8 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | HEYL;CDK8;ADAM10;CCNC;JAG2;HEY1;JAG1;HDAC5;MIB1 |
Constitutive Signaling by NOTCH1 PEST Domain Mutants | HDAC5;HEY2;HDAC6;ADAM10;JAG1;JAG2;CDK8;HEY1;CCNC |
Developmental Biology | HELZ2;EFNB1;KIF4A;CNKSR1;LGI4;CAP1;COL4A3;PLXNC1;MED6 |
Disease | KPNA5;FDX1L;MMADHC;SSRP1;TH1L;KREMEN1;OPN1MW;OS9;OPN1LW |
Diseases of signal transduction | MIB1;TNKS2;CUX1;JAG1;JAG2;RLBP1;RBP4;DERL2;HEY2 |
Fatty acid, triacylglycerol, and ketone body metabolism | PLIN2;PPARGC1B;MED23;CTGF;ACAD11;MMAA;DGAT1B;ACOT12;CPT2 |
Gene Expression | SF3B4;ZNF692;TET3;ZNF689;NR1H3;LSM11;GTF3A;CLNS1A;TRMT1 |
Generic Transcription Pathway | ZNF74;ZNF324;ZNF624;ZNF383;RNF111;ZNF167;JUNB;ZNF354A;ZNF253 |
CDK8 has several biochemical functions, for example, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK8 itself. We selected most functions CDK8 had, and list some proteins which have the same functions with CDK8. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CHD7;WEE2;NAGK;MAP2K2A;ACVR1BA;TNK2;MAT1A;ACTR3;NADK2 |
RNA polymerase II carboxy-terminal domain kinase activity | CDK1;CDK9;CDK7;CCNK;MAPK1;CDK12;CDK8;CDK13 |
cyclin-dependent protein serine/threonine kinase activity | CDK5R1;STK30;MAK;CDK11A;CDK16;NAT1;CDKL3;CDK14;CDK18 |
protein binding | TAF9B;CCNB3;LIMK1;SNRPN;TPD52L1;RBMS1;NUDT2;KIF13B;IL33 |
protein kinase activity | MAP3K4;CDK9;RAF1B;PTK7A;AKT3;IRAK1;RIPK3;PRKDC;PLK5 |
ubiquitin protein ligase activity | MED21;TRIM2;SYVN1;ARIH1;UBE2KA;HLTF;RNF2;RNF217;CBLC |
CDK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK8.
CCNC
- Q&As
- Reviews
Q&As (5)
Ask a questionCDK8 plays essential roles in normal cellular functions, including development and tissue homeostasis. Its dysregulation, however, is implicated in cancer.
Combination therapies involving CDK8 inhibitors are being explored to enhance treatment outcomes and reduce the likelihood of resistance, providing a more comprehensive approach to cancer management.
CDK8 inhibition can disrupt the cell cycle, slowing down or halting the uncontrolled cell division characteristic of cancer cells, making it a potential therapeutic strategy.
CDK8 can modulate the expression of genes involved in immune response. Understanding its role in the tumor microenvironment may lead to novel immunotherapeutic strategies.
Yes, several clinical trials are underway to assess the safety and effectiveness of CDK8 inhibitors as a targeted therapy for different types of cancer.
Customer Reviews (3)
Write a reviewThe CDK8 protein stands as a remarkable solution that exemplifies exceptional quality and meets all my experimental requirements.
I am confident that the CDK8 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.
Its impressive purity and functional characteristics make it an ideal choice for my research endeavors, ensuring reliable and impactful results.
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