CDK6
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Official Full Name
cyclin-dependent kinase 6
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Overview
The cyclin-dependent kinases form complexes with their cyclin partners and with CDK inhibitors. CDK6 and CDK4 associate with the D-type cyclins and target the retinoblastoma protein, allowing passage through the G1/S phase restriction point (1). CDK6/cycl -
Synonyms
CDK6; cyclin-dependent kinase 6; PLSTIRE; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; MGC59692;
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- N/A
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- Involved Pathway
- Protein Function
- Interacting Protein
- CDK6 Related Articles
- CDK6 Related Signal Pathway
CDK6 involved in several pathways and played different roles in them. We selected most pathways CDK6 participated on our site, such as B Cell Receptor Signaling Pathway, C-MYB transcription factor network, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | DAPP1;ARPC5;Cd79a, Cd79b;PTPN6;ARPC2;CD22;RAF1;BLNK;HRAS |
| C-MYB transcription factor network | MYF6;CLTA;SMARCA2;MYC;ADA;CEBPB;COL1A2;TOM1;PRTN3 |
| Cell Cycle | ARPP19;DKC1;GINS4;GORASP1;FGFR1OP;MAD1L1;SYCE1;ORC3L;LIN37 |
| Cell Cycle, Mitotic | FOXM1;CDCA8;MAPRE1A;DYNC1I2;LIN52;NUP35;DYRK1A;CEP72;SGOL2 |
| Cellular Senescence | HIRA;SUZ12A;H3F3D;HIST3H2BB;TNIK;CDK6;CBX8A;CBX4;Txn1 |
| Cellular responses to stress | PTGES3;CBX8A;UVRAG;SUZ12A;SCMH1;CBX6;DNAJB6;PRDX3;TERF2 |
| Chronic myeloid leukemia | MDM2;BRAF;AKT2;TRP53;IKBKB;CTBP1;SHC1;RELA;CBLC |
CDK6 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK6 itself. We selected most functions CDK6 had, and list some proteins which have the same functions with CDK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | C10orf2;APAF1;PPP1CA;PINK1;MLH3;RUVBL1;EIF4A2;VSIG8B;VRK1 |
| cyclin binding | PTCH1;USP2;CDK13;CDK4;CDKN1A;CDK14;FBXW7;PFTK1;HDAC3 |
| cyclin-dependent protein serine/threonine kinase activity | CDKL5;STK30;CDK19;CDK11A;CDK1;CDK3;CDK10;CDK11B;CDK12 |
| protein binding | GYPC;MRFAP1L1;LSM5;AAAS;PPP1R9A;CCNB3;SCAND1;EFHA1;TXLNG |
CDK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK6.
CDKN2A; CCND3
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of CDK6 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation processes of the CDK6 gene, thereby regulating its expression level in cells.
There are several challenges in the development of CDK6 inhibitors, including issues such as inhibitor selectivity, drug resistance, and drug delivery. In addition, since CDK6 also has a certain function in normal cells, the side effects of inhibitors are also a factor to consider.
It plays an important role in stem cell biology. It is involved in the process of self-renewal and differentiation of stem cells, as well as in determining the fate of stem cells. By regulating the activity of CDK6, it is possible to influence the proliferation and fate selection of stem cells.
CDK6 inhibitors have been developed as potential anti-cancer drugs and have shown some efficacy in clinical trials. They block the progression of the cell cycle by inhibiting the activity of CDK6, thereby inhibiting the proliferation of cancer cells.
The activity of CDK6 is regulated at multiple levels, including binding to other cyclins and inhibitors, phosphorylation and dephosphorylation events, and transcriptional and post-translational modifications.
The role of CDK6 in different types of cancer may vary. It may act as a promoter in some cancers and as a suppressant in others. This difference can be related to factors such as the type, stage, and genetic background of the cancer.
Customer Reviews (3)
Write a reviewThe results obtained after analysis by SDS-PAGE or Western blot were good.
It has a wide range of applications and can be used in various biological experiments.
The purity of CDK6 is good, and the experimental results obtained are very accurate.
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