| Description : |
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
153.1 kDa |
| AA Sequence : |
MGNQLAGIAPSQILSVESYFSDIHD FEYDKSLGSTRFFKVARAKHREGLV VVKVFAIQDPTLPLTSYKQELEELK IRLNSAQNCLPFQKASEKASEKAAM LFRQYVRDNLYDRISTRPFLNNIEK RWIAFQILTAVDQAHKSGVRHGDIK TENVMVTSWNWVLLTDFASFKPTYL PEDNPADFNYFFDTSRRRTCYIAPE RFVDGGMFATELEYMRDPSTPLVDL NSNQRTRGELKRAMDIFSAGCVIAE LFTEGVPLFDLSQLLAYRNGHFFPE QVLNKIEDHSIRELVTQMIHREPDK RLEAEDYLKQQRGNAFPEIFYTFLQ PYMAQFAKETFLSADERILVIRKDL GNIIHNLCGHDLPEKAEGEPKENGL VILVSVITSCLQTLKYCDSKLAALE LILHLAPRLSVEILLDRITPYLLHF SNDSVPRVRAEALRTLTKVLALVKE VPRNDINIYPEYILPGIAHLAQDDA TIVRLAYAENIALLAETALRFLELV QLKNLNMENDPNNEEIDEVTHPNGN YDTELQALHEMVQQKVVTLLSDPEN IVKQTLMENGITRLCVFFGRQKAND VLLSHMITFLNDKNDWHLRGAFFDS IVGVAAYVGWQSSSILKPLLQQGLS DAEEFVIVKALYALTCMCQLGLLQK PHVYEFASDIAPFLCHPNLWIRYGA VGFITVVARQISTADVYCKLMPYLD PYITQPIIQIERKLVLLSVLKEPVS RSIFDYALRSKDITSLFRHLHMRQK KRNGSLPDCPPPEDPAIAQLLKKLL SQGMTEEEEDKLLALKDFMMKSNKA KANIVDQSHLHDSSQKGVIDLAALG ITGRQVDLVKTKQEPDDKRARKHVK QDSNVNEEWKSMFGSLDPPNMPQAL PKGSDQEVIQTGKPPRSESSAGICV PLSTSSQVPEVTTVQNKKPVIPVLS STILPSTYQIRITTCKTELQQLIQQ KREQCNAERIAKQMMENAEWESKPP PPGWRPKGLLVAHLHEHKSAVNRIR VSDEHSLFATCSNDGTVKIWNSQKM EGKTTTTRSILTYSRIGGRVKTLTF CQGSHYLAIASDNGAVQLLGIEASK LPKSPKIHPLQSRILDQKEDGCVVD MHHFNSGAQSVLAYATVNGSLVGWD LRSSSNAWTLKHDLKSGLITSFAVD IHQCWLCIGTSSGTMACWDMRFQLP ISSHCHPSRARIRRLSMHPLYQSWV IAAVQGNNEVSMWDMETGDRRFTLW ASSAPPLSELQPSPHSVHGIYCSPA DGNPILLTAGSDMKIRFWDLAYPER SYVVAGSTSSPSVSYYRKIIEGTEV VQEIQNKQKVGPSDDTPRRGPESLP VGHHDIITDVATFQTTQGFIVTASR DGIVKVWKTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
